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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19561

FusionGeneSummary for LDLRAD1_FGGY

check button Fusion gene summary
Fusion gene informationFusion gene name: LDLRAD1_FGGY
Fusion gene ID: 19561
HgeneTgene
Gene symbol

LDLRAD1

FGGY

Gene ID

388633

55277

Gene namelow density lipoprotein receptor class A domain containing 1FGGY carbohydrate kinase domain containing
Synonyms--
Cytomap

1p32.3

1p32.1

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor class A domain-containing protein 1FGGY carbohydrate kinase domain-containing proteinD-ribulokinase
Modification date2018051920180519
UniProtAcc

Q5T700

Q96C11

Ensembl transtripts involved in fusion geneENST00000371362, ENST00000371360, 
ENST00000545928, ENST00000420619, 
ENST00000474476, ENST00000371218, 
ENST00000303721, ENST00000371212, 
ENST00000371210, 
Fusion gene scores* DoF score2 X 1 X 2=413 X 9 X 9=1053
# samples 214
** MAII scorelog2(2/4*10)=2.32192809488736log2(14/1053*10)=-2.91100670408075
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LDLRAD1 [Title/Abstract] AND FGGY [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGGY

GO:0019321

pentose metabolic process

27909055

TgeneFGGY

GO:0046835

carbohydrate phosphorylation

27909055


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E9-A1R7-01ALDLRAD1chr1

54475955

-FGGYchr1

59922633

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000371362ENST00000474476LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000371362ENST00000371218LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000371362ENST00000303721LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000371362ENST00000371212LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-intronENST00000371362ENST00000371210LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000371360ENST00000474476LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000371360ENST00000371218LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000371360ENST00000303721LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000371360ENST00000371212LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-intronENST00000371360ENST00000371210LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000545928ENST00000474476LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000545928ENST00000371218LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000545928ENST00000303721LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000545928ENST00000371212LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-intronENST00000545928ENST00000371210LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000420619ENST00000474476LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000420619ENST00000371218LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000420619ENST00000303721LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-3UTRENST00000420619ENST00000371212LDLRAD1chr1

54475955

-FGGYchr1

59922633

+
5CDS-intronENST00000420619ENST00000371210LDLRAD1chr1

54475955

-FGGYchr1

59922633

+

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FusionProtFeatures for LDLRAD1_FGGY


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LDLRAD1

Q5T700

FGGY

Q96C11


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LDLRAD1_FGGY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LDLRAD1_FGGY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LDLRAD1PLN, BNIP3, BNIP3L, PTTG1IP, MAL, SLC1A1, LAPTM5, MALL, TMEM147, VTI1B, OLFM4, MARCH2, GIMAP5, GPR128, TMEM190, TMEM218FGGYEAF1, NSFL1C


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LDLRAD1_FGGY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LDLRAD1_FGGY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource