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Fusion gene ID: 19534 |
FusionGeneSummary for LCOR_MAP2K6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LCOR_MAP2K6 | Fusion gene ID: 19534 | Hgene | Tgene | Gene symbol | LCOR | MAP2K6 | Gene ID | 84458 | 5608 |
| Gene name | ligand dependent nuclear receptor corepressor | mitogen-activated protein kinase kinase 6 | |
| Synonyms | C10orf12|MLR2 | MAPKK6|MEK6|MKK6|PRKMK6|SAPKK-3|SAPKK3 | |
| Cytomap | 10q24.1 | 17q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ligand-dependent corepressormblk1-related protein 2 | dual specificity mitogen-activated protein kinase kinase 6MAPK/ERK kinase 6MAPKK 6MEK 6SAPK kinase 3protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)stress-activated protein kinase kinase 3 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96JN0 | P52564 | |
| Ensembl transtripts involved in fusion gene | ENST00000540664, ENST00000371103, ENST00000356016, ENST00000371097, ENST00000498444, | ENST00000590474, ENST00000589647, | |
| Fusion gene scores | * DoF score | 8 X 4 X 6=192 | 5 X 4 X 3=60 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LCOR [Title/Abstract] AND MAP2K6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAP2K6 | GO:0000187 | activation of MAPK activity | 8663524|9218798 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-DK-AA76-01A | LCOR | chr10 | 98667504 | + | MAP2K6 | chr17 | 67521042 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000540664 | ENST00000590474 | LCOR | chr10 | 98667504 | + | MAP2K6 | chr17 | 67521042 | + |
| 5UTR-3CDS | ENST00000540664 | ENST00000589647 | LCOR | chr10 | 98667504 | + | MAP2K6 | chr17 | 67521042 | + |
| 5UTR-3CDS | ENST00000371103 | ENST00000590474 | LCOR | chr10 | 98667504 | + | MAP2K6 | chr17 | 67521042 | + |
| 5UTR-3CDS | ENST00000371103 | ENST00000589647 | LCOR | chr10 | 98667504 | + | MAP2K6 | chr17 | 67521042 | + |
| 5UTR-3CDS | ENST00000356016 | ENST00000590474 | LCOR | chr10 | 98667504 | + | MAP2K6 | chr17 | 67521042 | + |
| 5UTR-3CDS | ENST00000356016 | ENST00000589647 | LCOR | chr10 | 98667504 | + | MAP2K6 | chr17 | 67521042 | + |
| 5UTR-3CDS | ENST00000371097 | ENST00000590474 | LCOR | chr10 | 98667504 | + | MAP2K6 | chr17 | 67521042 | + |
| 5UTR-3CDS | ENST00000371097 | ENST00000589647 | LCOR | chr10 | 98667504 | + | MAP2K6 | chr17 | 67521042 | + |
| intron-3CDS | ENST00000498444 | ENST00000590474 | LCOR | chr10 | 98667504 | + | MAP2K6 | chr17 | 67521042 | + |
| intron-3CDS | ENST00000498444 | ENST00000589647 | LCOR | chr10 | 98667504 | + | MAP2K6 | chr17 | 67521042 | + |
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FusionProtFeatures for LCOR_MAP2K6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LCOR | MAP2K6 |
| Dual specificity protein kinase which acts as anessential component of the MAP kinase signal transduction pathway.With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of athreonine and a tyrosine residue in the MAP kinases p38 MAPK11,MAPK12, MAPK13 and MAPK14 and plays an important role in theregulation of cellular responses to cytokines and all kinds ofstresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are bothessential for the activation of MAPK11 and MAPK13 induced byenvironmental stress, whereas MAP2K6/MKK6 is the major MAPK11activator in response to TNF. MAP2K6/MKK6 also phosphorylates andactivates PAK6. The p38 MAP kinase signal transduction pathwayleads to direct activation of transcription factors. Nucleartargets of p38 MAP kinase include the transcription factors ATF2and ELK1. Within the p38 MAPK signal transduction pathway,MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14activation, and is therefore required for STAT4 activation andSTAT4-regulated gene expression in response to IL-12 stimulation.The pathway is also crucial for IL-6-induced SOCS3 expression anddown-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclastdifferentiation through NF-kappa-B transactivation by TNFSF11, andin endochondral ossification and since SOX9 is another likelydownstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediatesapoptotic cell death in thymocytes. Acts also as a regulator formelanocytes dendricity, through the modulation of Rho familyGTPases. {ECO:0000269|PubMed:10961885,ECO:0000269|PubMed:11727828, ECO:0000269|PubMed:15550393,ECO:0000269|PubMed:20869211, ECO:0000269|PubMed:8622669,ECO:0000269|PubMed:8626699, ECO:0000269|PubMed:8663074,ECO:0000269|PubMed:9218798}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LCOR_MAP2K6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LCOR_MAP2K6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LCOR | HDAC6, CTBP1, ESR1, VDR, HDAC1, HDAC3, HDAC4, CTBP2, KLF6, AR, GOLGA2, TRAF1, SLC25A6, RBPJ, KPNB1, CNOT2, SAMHD1, RAB4B, NDE1, USP43, LRWD1, SUZ12, POGZ, ZNF516, ASB3, MAPK14, USP7, ZYG11B, LRP1, LRPAP1, KLHDC3 | MAP2K6 | MAP3K7, MAPK14, SMAD7, MAP3K5, MAP3K4, TAOK2, PLCB2, NPHS1, MAP2K3, PTEN, TLR3, MAP2K4, LRRK2, MAPK12, PKN1, MLH1, MAPKAPK2, FBXO31, MAPK1, ZG16B, GADD45A, RELA, GNB2L1, TRAF6, DUSP4, CST1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LCOR_MAP2K6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LCOR_MAP2K6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MAP2K6 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Tgene | MAP2K6 | C0013604 | Edema | 1 | CTD_human |
| Tgene | MAP2K6 | C0020517 | Hypersensitivity | 1 | CTD_human |
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