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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19525

FusionGeneSummary for LCN2_MKL2

check button Fusion gene summary
Fusion gene informationFusion gene name: LCN2_MKL2
Fusion gene ID: 19525
HgeneTgene
Gene symbol

LCN2

MKL2

Gene ID

3934

57496

Gene namelipocalin 2MKL1/myocardin like 2
Synonyms24p3|MSFI|NGAL|p25MRTF-B|MRTFB|NPD001
Cytomap

9q34.11

16p13.12

Type of geneprotein-codingprotein-coding
Descriptionneutrophil gelatinase-associated lipocalin25 kDa alpha-2-microglobulin-related subunit of MMP-9migration-stimulating factor inhibitoroncogene 24p3siderocalin LCN2MKL/myocardin-like protein 2CTA-276F8.1MKL and myocardin family member 2MKL/myocardin like 2megakaryoblastic leukemia 2myocardin-related transcription factor B
Modification date2018052720180523
UniProtAcc

P80188

Q9ULH7

Ensembl transtripts involved in fusion geneENST00000373017, ENST00000470902, 
ENST00000540948, ENST00000277480, 
ENST00000373013, ENST00000372998, 
ENST00000571589, ENST00000574045, 
ENST00000318282, ENST00000572567, 
ENST00000341243, ENST00000575537, 
ENST00000573051, 
Fusion gene scores* DoF score3 X 3 X 4=363 X 3 X 3=27
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LCN2 [Title/Abstract] AND MKL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMKL2

GO:0045844

positive regulation of striated muscle tissue development

14565952

TgeneMKL2

GO:0045944

positive regulation of transcription by RNA polymerase II

14565952


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU742073LCN2chr9

130913963

-MKL2chr16

14332896

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373017ENST00000571589LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373017ENST00000574045LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373017ENST00000318282LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373017ENST00000572567LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373017ENST00000341243LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373017ENST00000575537LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373017ENST00000573051LCN2chr9

130913963

-MKL2chr16

14332896

-
3UTR-intronENST00000470902ENST00000571589LCN2chr9

130913963

-MKL2chr16

14332896

-
3UTR-intronENST00000470902ENST00000574045LCN2chr9

130913963

-MKL2chr16

14332896

-
3UTR-intronENST00000470902ENST00000318282LCN2chr9

130913963

-MKL2chr16

14332896

-
3UTR-intronENST00000470902ENST00000572567LCN2chr9

130913963

-MKL2chr16

14332896

-
3UTR-intronENST00000470902ENST00000341243LCN2chr9

130913963

-MKL2chr16

14332896

-
3UTR-intronENST00000470902ENST00000575537LCN2chr9

130913963

-MKL2chr16

14332896

-
3UTR-intronENST00000470902ENST00000573051LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000540948ENST00000571589LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000540948ENST00000574045LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000540948ENST00000318282LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000540948ENST00000572567LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000540948ENST00000341243LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000540948ENST00000575537LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000540948ENST00000573051LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000277480ENST00000571589LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000277480ENST00000574045LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000277480ENST00000318282LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000277480ENST00000572567LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000277480ENST00000341243LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000277480ENST00000575537LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000277480ENST00000573051LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373013ENST00000571589LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373013ENST00000574045LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373013ENST00000318282LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373013ENST00000572567LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373013ENST00000341243LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373013ENST00000575537LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000373013ENST00000573051LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000372998ENST00000571589LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000372998ENST00000574045LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000372998ENST00000318282LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000372998ENST00000572567LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000372998ENST00000341243LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000372998ENST00000575537LCN2chr9

130913963

-MKL2chr16

14332896

-
5CDS-intronENST00000372998ENST00000573051LCN2chr9

130913963

-MKL2chr16

14332896

-

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FusionProtFeatures for LCN2_MKL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LCN2

P80188

MKL2

Q9ULH7

Acts as a transcriptional coactivator of serum responsefactor (SRF). Required for skeletal myogenic differentiation.{ECO:0000269|PubMed:14565952}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LCN2_MKL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LCN2_MKL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LCN2_MKL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LCN2_MKL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLCN2C0022658Kidney Diseases4CTD_human
HgeneLCN2C2609414Acute kidney injury3CTD_human
HgeneLCN2C0023893Liver Cirrhosis, Experimental2CTD_human
HgeneLCN2C4277682Chemical and Drug Induced Liver Injury2CTD_human
HgeneLCN2C0003873Rheumatoid Arthritis1CTD_human
HgeneLCN2C0005283beta Thalassemia1CTD_human
HgeneLCN2C0006663Calcinosis1CTD_human
HgeneLCN2C0011616Contact Dermatitis1CTD_human
HgeneLCN2C0018824Heart valve disease1CTD_human
HgeneLCN2C0019188Hepatitis, Animal1CTD_human
HgeneLCN2C0021368Inflammation1CTD_human
HgeneLCN2C0027627Neoplasm Metastasis1CTD_human
HgeneLCN2C0035222Respiratory Distress Syndrome, Adult1CTD_human
HgeneLCN2C0036341Schizophrenia1PSYGENET
HgeneLCN2C0403447Chronic Kidney Insufficiency1CTD_human
TgeneMKL2C0008074Child Development Disorders, Pervasive1CTD_human