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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19504

FusionGeneSummary for LASP1_WIPF2

check button Fusion gene summary
Fusion gene informationFusion gene name: LASP1_WIPF2
Fusion gene ID: 19504
HgeneTgene
Gene symbol

LASP1

WIPF2

Gene ID

3927

147179

Gene nameLIM and SH3 protein 1WAS/WASL interacting protein family member 2
SynonymsLasp-1|MLN50WICH|WIRE
Cytomap

17q12

17q21.2

Type of geneprotein-codingprotein-coding
DescriptionLIM and SH3 domain protein 1metastatic lymph node gene 50 proteinWAS/WASL-interacting protein family member 2WASP-binding proteinWASP-interacting protein-related proteinWIP- and CR16-homologous proteinWIP-related protein
Modification date2018052220180523
UniProtAcc

Q14847

Q8TF74

Ensembl transtripts involved in fusion geneENST00000318008, ENST00000433206, 
ENST00000435347, 
ENST00000494757, 
ENST00000323571, ENST00000585043, 
ENST00000394103, ENST00000536600, 
ENST00000583130, 
Fusion gene scores* DoF score9 X 9 X 4=32411 X 5 X 5=275
# samples 1111
** MAII scorelog2(11/324*10)=-1.55849028935997
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/275*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LASP1 [Title/Abstract] AND WIPF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-D7-6815-01ALASP1chr17

37054772

+WIPF2chr17

38412643

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000318008ENST00000494757LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000318008ENST00000323571LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000318008ENST00000585043LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000318008ENST00000394103LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000318008ENST00000536600LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000318008ENST00000583130LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-intronENST00000433206ENST00000494757LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000433206ENST00000323571LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000433206ENST00000585043LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000433206ENST00000394103LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000433206ENST00000536600LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000433206ENST00000583130LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-intronENST00000435347ENST00000494757LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000435347ENST00000323571LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000435347ENST00000585043LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000435347ENST00000394103LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000435347ENST00000536600LASP1chr17

37054772

+WIPF2chr17

38412643

+
5CDS-5UTRENST00000435347ENST00000583130LASP1chr17

37054772

+WIPF2chr17

38412643

+

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FusionProtFeatures for LASP1_WIPF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LASP1

Q14847

WIPF2

Q8TF74

Plays an important role in the regulation of dynamicactin-based, cytoskeletal activities. Agonist-dependent changes inLASP1 phosphorylation may also serve to regulate actin-associatedion transport activities, not only in the parietal cell but alsoin certain other F-actin-rich secretory epithelial cell types (Bysimilarity). {ECO:0000250}. Plays an active role in the formation of cell surfaceprotrusions downstream of activated PDGFB receptors. Plays animportant role in actin-microspike formation through cooperationwith WASL. May cooperate with WASP and WASL to induce mobilizationand reorganization of the actin filament system.{ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LASP1_WIPF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LASP1_WIPF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LASP1TRIP13, PLSCR1, FHL3, MDFI, ZYX, TERF1, TINF2, ACD, POT1, ATXN1, FN1, DAZAP2, CD81, GOLGA2, PSMA3, REL, TRIM27, TCF4, FXR2, SPRY2, ARHGEF15, ZC2HC1A, THAP1, SEPT3, LZTS2, RHOXF2, KRTAP4-2, ZBTB9, ZDHHC17, CCDC8, ILK, HAX1, DNAAF2, THAP8, FYTTD1, NFYA, OR10H3, RDH12, SLC25A32, SLC25A44, C11orf65, TAS2R41, AHNAK, ARFGAP1, DDB1, EIF4B, HSPB1, HSPE1, LGALS1, MAP4, NXF1, CRK, STAT3, SH2D2A, CEP170, FBF1, SCLT1, DCTN1, U2AF2, CDH1, ZNF764, SNRNP27, PGK1, EZR, SPTAN1, NCL, UHRF1, NAT10, PDIA5, API5, KRT18, KRT2, G3BP2, AP3M1, NCOR2, CDK12, MYO1C, ACTR3, CLTC, DNMT1, EHMT2, SNAI1, HIST1H3A, TRIM25, TESWIPF2DNMBP, WAS, NCK2, GRB2, ITSN2, SH3KBP1, WASL, EIF4A3, TXLNG, SLC4A1AP, HNRNPDL, ZFAND5, ZNF830, TCERG1, APBB1, WWOX, PACSIN2, NCK1, CDH1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LASP1_WIPF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LASP1_WIPF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLASP1C0004352Autistic Disorder1CTD_human
HgeneLASP1C0036341Schizophrenia1PSYGENET