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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19500

FusionGeneSummary for LASP1_MTMR1

check button Fusion gene summary
Fusion gene informationFusion gene name: LASP1_MTMR1
Fusion gene ID: 19500
HgeneTgene
Gene symbol

LASP1

MTMR1

Gene ID

3927

8776

Gene nameLIM and SH3 protein 1myotubularin related protein 1
SynonymsLasp-1|MLN50-
Cytomap

17q12

Xq28

Type of geneprotein-codingprotein-coding
DescriptionLIM and SH3 domain protein 1metastatic lymph node gene 50 proteinmyotubularin-related protein 1phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphate phosphatase
Modification date2018052220180519
UniProtAcc

Q14847

Q13613

Ensembl transtripts involved in fusion geneENST00000318008, ENST00000433206, 
ENST00000435347, 
ENST00000541925, 
ENST00000542156, ENST00000370390, 
ENST00000451863, ENST00000544228, 
ENST00000445323, ENST00000538506, 
Fusion gene scores* DoF score9 X 9 X 4=3245 X 5 X 3=75
# samples 115
** MAII scorelog2(11/324*10)=-1.55849028935997
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LASP1 [Title/Abstract] AND MTMR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMTMR1

GO:0046856

phosphatidylinositol dephosphorylation

11733541|27018598

TgeneMTMR1

GO:0060304

regulation of phosphatidylinositol dephosphorylation

16787938


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB343893LASP1chr17

37077904

-MTMR1chrX

149931802

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000318008ENST00000541925LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-intronENST00000318008ENST00000542156LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-intronENST00000318008ENST00000370390LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-intronENST00000318008ENST00000451863LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-3UTRENST00000318008ENST00000544228LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-3UTRENST00000318008ENST00000445323LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-intronENST00000318008ENST00000538506LASP1chr17

37077904

-MTMR1chrX

149931802

-
intron-intronENST00000433206ENST00000541925LASP1chr17

37077904

-MTMR1chrX

149931802

-
intron-intronENST00000433206ENST00000542156LASP1chr17

37077904

-MTMR1chrX

149931802

-
intron-intronENST00000433206ENST00000370390LASP1chr17

37077904

-MTMR1chrX

149931802

-
intron-intronENST00000433206ENST00000451863LASP1chr17

37077904

-MTMR1chrX

149931802

-
intron-3UTRENST00000433206ENST00000544228LASP1chr17

37077904

-MTMR1chrX

149931802

-
intron-3UTRENST00000433206ENST00000445323LASP1chr17

37077904

-MTMR1chrX

149931802

-
intron-intronENST00000433206ENST00000538506LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-intronENST00000435347ENST00000541925LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-intronENST00000435347ENST00000542156LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-intronENST00000435347ENST00000370390LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-intronENST00000435347ENST00000451863LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-3UTRENST00000435347ENST00000544228LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-3UTRENST00000435347ENST00000445323LASP1chr17

37077904

-MTMR1chrX

149931802

-
3UTR-intronENST00000435347ENST00000538506LASP1chr17

37077904

-MTMR1chrX

149931802

-

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FusionProtFeatures for LASP1_MTMR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LASP1

Q14847

MTMR1

Q13613

Plays an important role in the regulation of dynamicactin-based, cytoskeletal activities. Agonist-dependent changes inLASP1 phosphorylation may also serve to regulate actin-associatedion transport activities, not only in the parietal cell but alsoin certain other F-actin-rich secretory epithelial cell types (Bysimilarity). {ECO:0000250}. Lipid phosphatase that has high specificity forphosphatidylinositol 3-phosphate and has no activity withphosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate(PubMed:11733541, PubMed:27018598). Activity withphosphatidylinositol (3,5)-bisphosphate is controversial; it hasbeen shown by PubMed:27018598, while PubMed:11733541 find noactivity with this substrate. {ECO:0000269|PubMed:11733541,ECO:0000269|PubMed:27018598}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LASP1_MTMR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LASP1_MTMR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LASP1_MTMR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LASP1_MTMR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLASP1C0004352Autistic Disorder1CTD_human
HgeneLASP1C0036341Schizophrenia1PSYGENET