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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19498

FusionGeneSummary for LASP1_EEF1A1

check button Fusion gene summary
Fusion gene informationFusion gene name: LASP1_EEF1A1
Fusion gene ID: 19498
HgeneTgene
Gene symbol

LASP1

EEF1A1

Gene ID

3927

1915

Gene nameLIM and SH3 protein 1eukaryotic translation elongation factor 1 alpha 1
SynonymsLasp-1|MLN50CCS-3|CCS3|EE1A1|EEF-1|EEF1A|EF-Tu|EF1A|GRAF-1EF|HNGC:16303|LENG7|PTI1|eEF1A-1
Cytomap

17q12

6q13

Type of geneprotein-codingprotein-coding
DescriptionLIM and SH3 domain protein 1metastatic lymph node gene 50 proteinelongation factor 1-alpha 1CTCL tumor antigenEF-1-alpha-1EF1a-like proteincervical cancer suppressor 3elongation factor 1 alpha subunitelongation factor Tueukaryotic elongation factor 1 A-1eukaryotic translation elongation factor 1 alpha 1-like 14
Modification date2018052220180523
UniProtAcc

Q14847

P68104

Ensembl transtripts involved in fusion geneENST00000318008, ENST00000433206, 
ENST00000435347, 
ENST00000316292, 
ENST00000491404, ENST00000309268, 
ENST00000331523, 
Fusion gene scores* DoF score9 X 9 X 4=3249 X 7 X 1=63
# samples 1110
** MAII scorelog2(11/324*10)=-1.55849028935997
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/63*10)=0.666576266274808
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LASP1 [Title/Abstract] AND EEF1A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEEF1A1

GO:0071364

cellular response to epidermal growth factor stimulus

9852145


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC001412LASP1chr17

37075167

+EEF1A1chr6

74230769

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000318008ENST00000316292LASP1chr17

37075167

+EEF1A1chr6

74230769

-
3UTR-intronENST00000318008ENST00000491404LASP1chr17

37075167

+EEF1A1chr6

74230769

-
3UTR-5UTRENST00000318008ENST00000309268LASP1chr17

37075167

+EEF1A1chr6

74230769

-
3UTR-intronENST00000318008ENST00000331523LASP1chr17

37075167

+EEF1A1chr6

74230769

-
3UTR-intronENST00000433206ENST00000316292LASP1chr17

37075167

+EEF1A1chr6

74230769

-
3UTR-intronENST00000433206ENST00000491404LASP1chr17

37075167

+EEF1A1chr6

74230769

-
3UTR-5UTRENST00000433206ENST00000309268LASP1chr17

37075167

+EEF1A1chr6

74230769

-
3UTR-intronENST00000433206ENST00000331523LASP1chr17

37075167

+EEF1A1chr6

74230769

-
3UTR-intronENST00000435347ENST00000316292LASP1chr17

37075167

+EEF1A1chr6

74230769

-
3UTR-intronENST00000435347ENST00000491404LASP1chr17

37075167

+EEF1A1chr6

74230769

-
3UTR-5UTRENST00000435347ENST00000309268LASP1chr17

37075167

+EEF1A1chr6

74230769

-
3UTR-intronENST00000435347ENST00000331523LASP1chr17

37075167

+EEF1A1chr6

74230769

-

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FusionProtFeatures for LASP1_EEF1A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LASP1

Q14847

EEF1A1

P68104

Plays an important role in the regulation of dynamicactin-based, cytoskeletal activities. Agonist-dependent changes inLASP1 phosphorylation may also serve to regulate actin-associatedion transport activities, not only in the parietal cell but alsoin certain other F-actin-rich secretory epithelial cell types (Bysimilarity). {ECO:0000250}. This protein promotes the GTP-dependent binding ofaminoacyl-tRNA to the A-site of ribosomes during proteinbiosynthesis. With PARP1 and TXK, forms a complex that acts as a Thelper 1 (Th1) cell-specific transcription factor and binds thepromoter of IFN-gamma to directly regulate its transcription, andis thus involved importantly in Th1 cytokine production.{ECO:0000269|PubMed:17177976}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LASP1_EEF1A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LASP1_EEF1A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LASP1_EEF1A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneEEF1A1P68104DB01593ZincElongation factor 1-alpha 1small moleculeapproved|investigational
TgeneEEF1A1P68104DB11638ArtenimolElongation factor 1-alpha 1small moleculeapproved|investigational

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RelatedDiseases for LASP1_EEF1A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLASP1C0004352Autistic Disorder1CTD_human
HgeneLASP1C0036341Schizophrenia1PSYGENET
TgeneEEF1A1C0024667Animal Mammary Neoplasms1CTD_human
TgeneEEF1A1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneEEF1A1C0038356Stomach Neoplasms1CTD_human