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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19493

FusionGeneSummary for LARS_PIGB

check button Fusion gene summary
Fusion gene informationFusion gene name: LARS_PIGB
Fusion gene ID: 19493
HgeneTgene
Gene symbol

LARS

PIGB

Gene ID

51520

9488

Gene nameleucyl-tRNA synthetasephosphatidylinositol glycan anchor biosynthesis class B
SynonymsHSPC192|ILFS1|LARS1|LEURS|LEUS|LFIS|LRS|PIG44|RNTLS|hr025ClGPI-MT-III|PIG-B
Cytomap

5q32

15q21.3

Type of geneprotein-codingprotein-coding
Descriptionleucine--tRNA ligase, cytoplasmiccytoplasmic leucyl-tRNA synthetasecytosolic leucyl-tRNA synthetaseleucine tRNA ligase 1, cytoplasmicleucine translaseproliferation-inducing gene 44GPI mannosyltransferase 3GPI mannosyltransferase IIIdol-P-Man dependent GPI mannosyltransferasephosphatidylinositol glycan, class Bphosphatidylinositol-glycan biosynthesis class B protein
Modification date2018052320180523
UniProtAcc

Q9P2J5

Q92521

Ensembl transtripts involved in fusion geneENST00000394434, ENST00000545646, 
ENST00000274562, ENST00000510191, 
ENST00000511505, 
ENST00000539642, 
ENST00000164305, ENST00000569909, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: LARS [Title/Abstract] AND PIGB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLARS

GO:0006425

glutaminyl-tRNA aminoacylation

26869582

TgenePIGB

GO:0006506

GPI anchor biosynthetic process

8861954

TgenePIGB

GO:0097502

mannosylation

8861954


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF352298LARSchr5

145500047

-PIGBchr15

55638405

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000394434ENST00000539642LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000394434ENST00000164305LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000394434ENST00000569909LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000545646ENST00000539642LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000545646ENST00000164305LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000545646ENST00000569909LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000274562ENST00000539642LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000274562ENST00000164305LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000274562ENST00000569909LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000510191ENST00000539642LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000510191ENST00000164305LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000510191ENST00000569909LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000511505ENST00000539642LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000511505ENST00000164305LARSchr5

145500047

-PIGBchr15

55638405

-
intron-intronENST00000511505ENST00000569909LARSchr5

145500047

-PIGBchr15

55638405

-

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FusionProtFeatures for LARS_PIGB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LARS

Q9P2J5

PIGB

Q92521

Catalyzes the specific attachment of an amino acid toits cognate tRNA in a two step reaction: the amino acid (AA) isfirst activated by ATP to form AA-AMP and then transferred to theacceptor end of the tRNA. Exhibits a post-transfer editingactivity to hydrolyze mischarged tRNAs.{ECO:0000269|PubMed:19426743}. Mannosyltransferase involved inglycosylphosphatidylinositol-anchor biosynthesis. Transfers thethird alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursorassembly. {ECO:0000269|PubMed:8861954}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LARS_PIGB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LARS_PIGB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LARS_PIGB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LARS_PIGB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLARSC3809522INFANTILE LIVER FAILURE SYNDROME 11ORPHANET;UNIPROT