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Fusion gene ID: 19493 |
FusionGeneSummary for LARS_PIGB |
Fusion gene summary |
Fusion gene information | Fusion gene name: LARS_PIGB | Fusion gene ID: 19493 | Hgene | Tgene | Gene symbol | LARS | PIGB | Gene ID | 51520 | 9488 |
Gene name | leucyl-tRNA synthetase | phosphatidylinositol glycan anchor biosynthesis class B | |
Synonyms | HSPC192|ILFS1|LARS1|LEURS|LEUS|LFIS|LRS|PIG44|RNTLS|hr025Cl | GPI-MT-III|PIG-B | |
Cytomap | 5q32 | 15q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | leucine--tRNA ligase, cytoplasmiccytoplasmic leucyl-tRNA synthetasecytosolic leucyl-tRNA synthetaseleucine tRNA ligase 1, cytoplasmicleucine translaseproliferation-inducing gene 44 | GPI mannosyltransferase 3GPI mannosyltransferase IIIdol-P-Man dependent GPI mannosyltransferasephosphatidylinositol glycan, class Bphosphatidylinositol-glycan biosynthesis class B protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9P2J5 | Q92521 | |
Ensembl transtripts involved in fusion gene | ENST00000394434, ENST00000545646, ENST00000274562, ENST00000510191, ENST00000511505, | ENST00000539642, ENST00000164305, ENST00000569909, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: LARS [Title/Abstract] AND PIGB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LARS | GO:0006425 | glutaminyl-tRNA aminoacylation | 26869582 |
Tgene | PIGB | GO:0006506 | GPI anchor biosynthetic process | 8861954 |
Tgene | PIGB | GO:0097502 | mannosylation | 8861954 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF352298 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000394434 | ENST00000539642 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000394434 | ENST00000164305 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000394434 | ENST00000569909 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000545646 | ENST00000539642 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000545646 | ENST00000164305 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000545646 | ENST00000569909 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000274562 | ENST00000539642 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000274562 | ENST00000164305 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000274562 | ENST00000569909 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000510191 | ENST00000539642 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000510191 | ENST00000164305 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000510191 | ENST00000569909 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000511505 | ENST00000539642 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000511505 | ENST00000164305 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
intron-intron | ENST00000511505 | ENST00000569909 | LARS | chr5 | 145500047 | - | PIGB | chr15 | 55638405 | - |
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FusionProtFeatures for LARS_PIGB |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
LARS | PIGB |
Catalyzes the specific attachment of an amino acid toits cognate tRNA in a two step reaction: the amino acid (AA) isfirst activated by ATP to form AA-AMP and then transferred to theacceptor end of the tRNA. Exhibits a post-transfer editingactivity to hydrolyze mischarged tRNAs.{ECO:0000269|PubMed:19426743}. | Mannosyltransferase involved inglycosylphosphatidylinositol-anchor biosynthesis. Transfers thethird alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursorassembly. {ECO:0000269|PubMed:8861954}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LARS_PIGB |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LARS_PIGB |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LARS_PIGB |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LARS_PIGB |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LARS | C3809522 | INFANTILE LIVER FAILURE SYNDROME 1 | 1 | ORPHANET;UNIPROT |