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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 19487

FusionGeneSummary for LARS2_ANO10

check button Fusion gene summary
Fusion gene informationFusion gene name: LARS2_ANO10
Fusion gene ID: 19487
HgeneTgene
Gene symbol

LARS2

ANO10

Gene ID

23395

55129

Gene nameleucyl-tRNA synthetase 2, mitochondrialanoctamin 10
SynonymsHLASA|LEURS|PRLTS4|mtLeuRSSCAR10|TMEM16K
Cytomap

3p21.31

3p22.1-p21.33

Type of geneprotein-codingprotein-coding
Descriptionprobable leucine--tRNA ligase, mitochondrialleucine tRNA ligase 2, mitochondrialleucine tRNA ligase 2, mitocondrialleucine translaseprobable leucyl-tRNA synthetase, mitochondrialanoctamin-10transmembrane protein 16K
Modification date2018052320180519
UniProtAcc

Q15031

Q9NW15

Ensembl transtripts involved in fusion geneENST00000265537, ENST00000415258, 
ENST00000414984, ENST00000467936, 
ENST00000292246, ENST00000350459, 
ENST00000396091, ENST00000414522, 
ENST00000451430, ENST00000495772, 
Fusion gene scores* DoF score5 X 4 X 4=805 X 4 X 3=60
# samples 56
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/60*10)=0
Context

PubMed: LARS2 [Title/Abstract] AND ANO10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLARS2

GO:0006429

leucyl-tRNA aminoacylation

10684970

TgeneANO10

GO:0006812

cation transport

22946059

TgeneANO10

GO:0006821

chloride transport

22946059


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVDLBCTCGA-FA-8693-01ALARS2chr3

45542071

+ANO10chr3

43408466

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265537ENST00000292246LARS2chr3

45542071

+ANO10chr3

43408466

-
Frame-shiftENST00000265537ENST00000350459LARS2chr3

45542071

+ANO10chr3

43408466

-
In-frameENST00000265537ENST00000396091LARS2chr3

45542071

+ANO10chr3

43408466

-
5CDS-3UTRENST00000265537ENST00000414522LARS2chr3

45542071

+ANO10chr3

43408466

-
5CDS-3UTRENST00000265537ENST00000451430LARS2chr3

45542071

+ANO10chr3

43408466

-
5CDS-intronENST00000265537ENST00000495772LARS2chr3

45542071

+ANO10chr3

43408466

-
In-frameENST00000415258ENST00000292246LARS2chr3

45542071

+ANO10chr3

43408466

-
Frame-shiftENST00000415258ENST00000350459LARS2chr3

45542071

+ANO10chr3

43408466

-
In-frameENST00000415258ENST00000396091LARS2chr3

45542071

+ANO10chr3

43408466

-
5CDS-3UTRENST00000415258ENST00000414522LARS2chr3

45542071

+ANO10chr3

43408466

-
5CDS-3UTRENST00000415258ENST00000451430LARS2chr3

45542071

+ANO10chr3

43408466

-
5CDS-intronENST00000415258ENST00000495772LARS2chr3

45542071

+ANO10chr3

43408466

-
In-frameENST00000414984ENST00000292246LARS2chr3

45542071

+ANO10chr3

43408466

-
Frame-shiftENST00000414984ENST00000350459LARS2chr3

45542071

+ANO10chr3

43408466

-
In-frameENST00000414984ENST00000396091LARS2chr3

45542071

+ANO10chr3

43408466

-
5CDS-3UTRENST00000414984ENST00000414522LARS2chr3

45542071

+ANO10chr3

43408466

-
5CDS-3UTRENST00000414984ENST00000451430LARS2chr3

45542071

+ANO10chr3

43408466

-
5CDS-intronENST00000414984ENST00000495772LARS2chr3

45542071

+ANO10chr3

43408466

-
3UTR-3CDSENST00000467936ENST00000292246LARS2chr3

45542071

+ANO10chr3

43408466

-
3UTR-3CDSENST00000467936ENST00000350459LARS2chr3

45542071

+ANO10chr3

43408466

-
3UTR-3CDSENST00000467936ENST00000396091LARS2chr3

45542071

+ANO10chr3

43408466

-
3UTR-3UTRENST00000467936ENST00000414522LARS2chr3

45542071

+ANO10chr3

43408466

-
3UTR-3UTRENST00000467936ENST00000451430LARS2chr3

45542071

+ANO10chr3

43408466

-
3UTR-intronENST00000467936ENST00000495772LARS2chr3

45542071

+ANO10chr3

43408466

-

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FusionProtFeatures for LARS2_ANO10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LARS2

Q15031

ANO10

Q9NW15


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLARS2chr3:45542071chr3:43408466ENST00000265537+152292_102586904MotifNote="HIGH" region
HgeneLARS2chr3:45542071chr3:43408466ENST00000415258+142192_102586904MotifNote="HIGH" region
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012522_553448471Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012575_590448471Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012612_660448471Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012575_590572595Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012612_660572595Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911575_590527550Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911612_660527550Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012501_521448471TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012554_574448471TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012591_611448471TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012591_611572595TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911554_574527550TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911591_611527550TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLARS2chr3:45542071chr3:43408466ENST00000265537+1522639_643586904MotifNote="KMSKS" region
HgeneLARS2chr3:45542071chr3:43408466ENST00000415258+1421639_643586904MotifNote="KMSKS" region
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-11131_207638661Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113229_240638661Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113262_316638661Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113338_352638661Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113374_400638661Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113422_500638661Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113522_553638661Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113575_590638661Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113612_660638661Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-10121_207448471Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012229_240448471Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012262_316448471Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012338_352448471Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012374_400448471Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012422_500448471Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-10121_207572595Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012229_240572595Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012262_316572595Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012338_352572595Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012374_400572595Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012422_500572595Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012522_553572595Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-11131_207639723Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113229_240639723Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113262_316639723Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113338_352639723Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113374_400639723Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113422_500639723Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113522_553639723Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113575_590639723Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113612_660639723Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-9111_207527550Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911229_240527550Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911262_316527550Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911338_352527550Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911374_400527550Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911422_500527550Topological domainExtracellular
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911522_553527550Topological domainCytoplasmic
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113208_228638661TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113241_261638661TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113317_337638661TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113353_373638661TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113401_421638661TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113501_521638661TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113554_574638661TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000292246-1113591_611638661TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012208_228448471TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012241_261448471TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012317_337448471TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012353_373448471TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000350459-1012401_421448471TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012208_228572595TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012241_261572595TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012317_337572595TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012353_373572595TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012401_421572595TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012501_521572595TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000396091-1012554_574572595TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113208_228639723TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113241_261639723TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113317_337639723TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113353_373639723TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113401_421639723TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113501_521639723TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113554_574639723TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000414522-1113591_611639723TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911208_228527550TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911241_261527550TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911317_337527550TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911353_373527550TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911401_421527550TransmembraneHelical
TgeneANO10chr3:45542071chr3:43408466ENST00000451430-911501_521527550TransmembraneHelical


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FusionGeneSequence for LARS2_ANO10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LARS2_ENST00000265537_chr3_45542071_+_ANO10_ENST00000292246_chr3_43408466_-_609aa
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMF
PYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQA
HWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLIS
RQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH

>In-frame_LARS2_ENST00000265537_chr3_45542071_+_ANO10_ENST00000396091_chr3_43408466_-_609aa
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMF
PYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQA
HWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLIS
RQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH

>In-frame_LARS2_ENST00000415258_chr3_45542071_+_ANO10_ENST00000292246_chr3_43408466_-_609aa
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMF
PYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQA
HWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLIS
RQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH

>In-frame_LARS2_ENST00000415258_chr3_45542071_+_ANO10_ENST00000396091_chr3_43408466_-_609aa
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMF
PYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQA
HWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLIS
RQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH

>In-frame_LARS2_ENST00000414984_chr3_45542071_+_ANO10_ENST00000292246_chr3_43408466_-_566aa
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADVINPMGWDAFGL
PAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEH
GCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVA
ISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPD
GTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGP
PLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKM

>In-frame_LARS2_ENST00000414984_chr3_45542071_+_ANO10_ENST00000396091_chr3_43408466_-_566aa
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADVINPMGWDAFGL
PAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEH
GCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVA
ISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPD
GTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGP
PLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKM


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LARS2_ENST00000265537_chr3_45542071_+_ANO10_ENST00000292246_chr3_43408466_-_1829nt
ATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGG
AGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAG
AAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTACGTGCTTTCCATGTTC
CCTTATCCTTCTGGTAAGCTGCACATGGGCCATGTGCGTGTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATG
CAGGTCATCAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACA
CAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGCCAGAT
TACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTATGAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTTAACTGGGACCCAGTG
GATCAAACAGTGCTTGCCAATGAGCAGGTGGATGAACATGGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGACAA
TGGTTTATTAAGACAACCGCTTATGCAAAGGCCATGCAGGACGCGTTGGCAGACCTTCCAGAATGGTATGGAATAAAAGGCATGCAAGCC
CACTGGATTGGGGACTGTGTGGGCTGCCACCTGGACTTCACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTATACG
GCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCCATCTCGCCCAGCCACAGACTCCTACATGGGCACAGCTCTCTGAAGGAAGCC
TTGAGGATGGCCCTTGTCCCTGGCAAAGATTGCCTCACGCCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTTATT
TTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAAATAGGAATTCCCAGTACTAGCTCAGAGGACACCATCTTAGCCCAAACCCTG
GGCCTGGCCTACTCTGAAGTCATTGAAACTTTGCCAGATGGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCCGGCAG
GATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAGAGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAAGACTGGCTGATTTCA
CGGCAGCGGTACTGGGGCACACCAATCCCCATTGTCCACTGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTGACC
CTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCCCCACTGGCCATGGCTTCAGAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAG
GGAGCAGCCAAGAGAGAGACAGACACGATGGATACCTTTGTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCACAC
AGCCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCTGTGGATTTGTACATTGGAGGGAAAGAACATGCCGTCATGCACTTGTTCTAT
GCAAGATTCTTTAGTCATTTTTGCCATGATCAAAAAATGGTTAAACATAGCAAATGAAGCTCGTGACCGAGAACCTGAAGGAGGAACCAA

>In-frame_LARS2_ENST00000265537_chr3_45542071_+_ANO10_ENST00000396091_chr3_43408466_-_1829nt
ATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGG
AGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAG
AAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTACGTGCTTTCCATGTTC
CCTTATCCTTCTGGTAAGCTGCACATGGGCCATGTGCGTGTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATG
CAGGTCATCAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACA
CAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGCCAGAT
TACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTATGAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTTAACTGGGACCCAGTG
GATCAAACAGTGCTTGCCAATGAGCAGGTGGATGAACATGGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGACAA
TGGTTTATTAAGACAACCGCTTATGCAAAGGCCATGCAGGACGCGTTGGCAGACCTTCCAGAATGGTATGGAATAAAAGGCATGCAAGCC
CACTGGATTGGGGACTGTGTGGGCTGCCACCTGGACTTCACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTATACG
GCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCCATCTCGCCCAGCCACAGACTCCTACATGGGCACAGCTCTCTGAAGGAAGCC
TTGAGGATGGCCCTTGTCCCTGGCAAAGATTGCCTCACGCCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTTATT
TTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAAATAGGAATTCCCAGTACTAGCTCAGAGGACACCATCTTAGCCCAAACCCTG
GGCCTGGCCTACTCTGAAGTCATTGAAACTTTGCCAGATGGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCCGGCAG
GATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAGAGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAAGACTGGCTGATTTCA
CGGCAGCGGTACTGGGGCACACCAATCCCCATTGTCCACTGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTGACC
CTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCCCCACTGGCCATGGCTTCAGAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAG
GGAGCAGCCAAGAGAGAGACAGACACGATGGATACCTTTGTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCACAC
AGCCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCTGTGGATTTGTACATTGGAGGGAAAGAACATGCCGTCATGCACTTGTTCTAT
GCAAGATTCTTTAGTCATTTTTGCCATGATCAAAAAATGGTTAAACATAGCAAATGAAGCTCGTGACCGAGAACCTGAAGGAGGAACCAA

>In-frame_LARS2_ENST00000415258_chr3_45542071_+_ANO10_ENST00000292246_chr3_43408466_-_1829nt
ATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGG
AGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAG
AAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTACGTGCTTTCCATGTTC
CCTTATCCTTCTGGTAAGCTGCACATGGGCCATGTGCGTGTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATG
CAGGTCATCAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACA
CAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGCCAGAT
TACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTATGAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTTAACTGGGACCCAGTG
GATCAAACAGTGCTTGCCAATGAGCAGGTGGATGAACATGGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGACAA
TGGTTTATTAAGACAACCGCTTATGCAAAGGCCATGCAGGACGCGTTGGCAGACCTTCCAGAATGGTATGGAATAAAAGGCATGCAAGCC
CACTGGATTGGGGACTGTGTGGGCTGCCACCTGGACTTCACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTATACG
GCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCCATCTCGCCCAGCCACAGACTCCTACATGGGCACAGCTCTCTGAAGGAAGCC
TTGAGGATGGCCCTTGTCCCTGGCAAAGATTGCCTCACGCCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTTATT
TTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAAATAGGAATTCCCAGTACTAGCTCAGAGGACACCATCTTAGCCCAAACCCTG
GGCCTGGCCTACTCTGAAGTCATTGAAACTTTGCCAGATGGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCCGGCAG
GATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAGAGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAAGACTGGCTGATTTCA
CGGCAGCGGTACTGGGGCACACCAATCCCCATTGTCCACTGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTGACC
CTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCCCCACTGGCCATGGCTTCAGAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAG
GGAGCAGCCAAGAGAGAGACAGACACGATGGATACCTTTGTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCACAC
AGCCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCTGTGGATTTGTACATTGGAGGGAAAGAACATGCCGTCATGCACTTGTTCTAT
GCAAGATTCTTTAGTCATTTTTGCCATGATCAAAAAATGGTTAAACATAGCAAATGAAGCTCGTGACCGAGAACCTGAAGGAGGAACCAA

>In-frame_LARS2_ENST00000415258_chr3_45542071_+_ANO10_ENST00000396091_chr3_43408466_-_1829nt
ATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGG
AGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAG
AAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTACGTGCTTTCCATGTTC
CCTTATCCTTCTGGTAAGCTGCACATGGGCCATGTGCGTGTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATG
CAGGTCATCAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACA
CAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGCCAGAT
TACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTATGAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTTAACTGGGACCCAGTG
GATCAAACAGTGCTTGCCAATGAGCAGGTGGATGAACATGGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGACAA
TGGTTTATTAAGACAACCGCTTATGCAAAGGCCATGCAGGACGCGTTGGCAGACCTTCCAGAATGGTATGGAATAAAAGGCATGCAAGCC
CACTGGATTGGGGACTGTGTGGGCTGCCACCTGGACTTCACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTATACG
GCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCCATCTCGCCCAGCCACAGACTCCTACATGGGCACAGCTCTCTGAAGGAAGCC
TTGAGGATGGCCCTTGTCCCTGGCAAAGATTGCCTCACGCCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTTATT
TTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAAATAGGAATTCCCAGTACTAGCTCAGAGGACACCATCTTAGCCCAAACCCTG
GGCCTGGCCTACTCTGAAGTCATTGAAACTTTGCCAGATGGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCCGGCAG
GATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAGAGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAAGACTGGCTGATTTCA
CGGCAGCGGTACTGGGGCACACCAATCCCCATTGTCCACTGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTGACC
CTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCCCCACTGGCCATGGCTTCAGAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAG
GGAGCAGCCAAGAGAGAGACAGACACGATGGATACCTTTGTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCACAC
AGCCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCTGTGGATTTGTACATTGGAGGGAAAGAACATGCCGTCATGCACTTGTTCTAT
GCAAGATTCTTTAGTCATTTTTGCCATGATCAAAAAATGGTTAAACATAGCAAATGAAGCTCGTGACCGAGAACCTGAAGGAGGAACCAA

>In-frame_LARS2_ENST00000414984_chr3_45542071_+_ANO10_ENST00000292246_chr3_43408466_-_1700nt
ATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGG
AGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAG
AAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGATGTCATCAACCCCATGGGATGGGATGCTTTTGGATTG
CCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGT
CTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGCCAGATTACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTAT
GAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTTAACTGGGACCCAGTGGATCAAACAGTGCTTGCCAATGAGCAGGTGGATGAACAT
GGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGACAATGGTTTATTAAGACAACCGCTTATGCAAAGGCCATGCAG
GACGCGTTGGCAGACCTTCCAGAATGGTATGGAATAAAAGGCATGCAAGCCCACTGGATTGGGGACTGTGTGGGCTGCCACCTGGACTTC
ACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTATACGGCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCC
ATCTCGCCCAGCCACAGACTCCTACATGGGCACAGCTCTCTGAAGGAAGCCTTGAGGATGGCCCTTGTCCCTGGCAAAGATTGCCTCACG
CCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTTATTTTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAA
ATAGGAATTCCCAGTACTAGCTCAGAGGACACCATCTTAGCCCAAACCCTGGGCCTGGCCTACTCTGAAGTCATTGAAACTTTGCCAGAT
GGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCCGGCAGGATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAG
AGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAAGACTGGCTGATTTCACGGCAGCGGTACTGGGGCACACCAATCCCCATTGTCCAC
TGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTGACCCTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCC
CCACTGGCCATGGCTTCAGAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAGGGAGCAGCCAAGAGAGAGACAGACACGATGGATACCTTT
GTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCACACAGCCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCT
GTGGATTTGTACATTGGAGGGAAAGAACATGCCGTCATGCACTTGTTCTATGCAAGATTCTTTAGTCATTTTTGCCATGATCAAAAAATG

>In-frame_LARS2_ENST00000414984_chr3_45542071_+_ANO10_ENST00000396091_chr3_43408466_-_1700nt
ATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGG
AGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAG
AAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGATGTCATCAACCCCATGGGATGGGATGCTTTTGGATTG
CCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGT
CTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGCCAGATTACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTAT
GAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTTAACTGGGACCCAGTGGATCAAACAGTGCTTGCCAATGAGCAGGTGGATGAACAT
GGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGACAATGGTTTATTAAGACAACCGCTTATGCAAAGGCCATGCAG
GACGCGTTGGCAGACCTTCCAGAATGGTATGGAATAAAAGGCATGCAAGCCCACTGGATTGGGGACTGTGTGGGCTGCCACCTGGACTTC
ACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTATACGGCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCC
ATCTCGCCCAGCCACAGACTCCTACATGGGCACAGCTCTCTGAAGGAAGCCTTGAGGATGGCCCTTGTCCCTGGCAAAGATTGCCTCACG
CCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTTATTTTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAA
ATAGGAATTCCCAGTACTAGCTCAGAGGACACCATCTTAGCCCAAACCCTGGGCCTGGCCTACTCTGAAGTCATTGAAACTTTGCCAGAT
GGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCCGGCAGGATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAG
AGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAAGACTGGCTGATTTCACGGCAGCGGTACTGGGGCACACCAATCCCCATTGTCCAC
TGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTGACCCTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCC
CCACTGGCCATGGCTTCAGAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAGGGAGCAGCCAAGAGAGAGACAGACACGATGGATACCTTT
GTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCACACAGCCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCT
GTGGATTTGTACATTGGAGGGAAAGAACATGCCGTCATGCACTTGTTCTATGCAAGATTCTTTAGTCATTTTTGCCATGATCAAAAAATG


* Fusion transcript sequences (Full-length transcript).
>In-frame_LARS2_ENST00000265537_chr3_45542071_+_ANO10_ENST00000292246_chr3_43408466_-_3149nt
GTTGCTCTCCTCCCTTCCCCGGTCCCGCCCCCGTCTGTCTGTGTCGACTGCGGACGCTATCGATAAAGTTGCTGTTTTGACAACATGGCG
GCGCCCATGGTCCGTGGCCCGGCAGTGCTCGCCTAAAGGTGGAGAACGAGGAGTAGAGGAGCCGCAGGCCAGAGCCTGTGAGCAGATCCA
GACCTACAGATAAAAAACATTATTTAATCTATCTGGGATTTACTCCGGCTTATGATTTGAGGGCCTTCTCACCTTCTGAAGAATGGCTTC
TGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAAT
TCCCGGATGTACCAGAAGCATCTACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAGAAATGGTG
GCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTACGTGCTTTCCATGTTCCCTTATCC
TTCTGGTAAGCTGCACATGGGCCATGTGCGTGTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATGCAGGTCAT
CAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAGTAA
TATTAAACACATGAGGAAACAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGCCAGATTACTACAA
GTGGACTCAGTATCTCTTTATTAAACTGTATGAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTTAACTGGGACCCAGTGGATCAAAC
AGTGCTTGCCAATGAGCAGGTGGATGAACATGGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGACAATGGTTTAT
TAAGACAACCGCTTATGCAAAGGCCATGCAGGACGCGTTGGCAGACCTTCCAGAATGGTATGGAATAAAAGGCATGCAAGCCCACTGGAT
TGGGGACTGTGTGGGCTGCCACCTGGACTTCACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTATACGGCCACCCC
TGAAGCCATTTATGGCACCTCCCACGTGGCCATCTCGCCCAGCCACAGACTCCTACATGGGCACAGCTCTCTGAAGGAAGCCTTGAGGAT
GGCCCTTGTCCCTGGCAAAGATTGCCTCACGCCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTTATTTTGGCCAA
AGCTGACTTGGAAGGCTCTCTGGATTCAAAAATAGGAATTCCCAGTACTAGCTCAGAGGACACCATCTTAGCCCAAACCCTGGGCCTGGC
CTACTCTGAAGTCATTGAAACTTTGCCAGATGGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCCGGCAGGATGCTTT
TCTAGCCCTGACTCAGAAAGCCCGGGGGAAGAGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAAGACTGGCTGATTTCACGGCAGCG
GTACTGGGGCACACCAATCCCCATTGTCCACTGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTGACCCTGCCCAA
CATCGCGTCTTTCACTGGCAAGGGAGGCCCCCCACTGGCCATGGCTTCAGAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAGGGAGCAGC
CAAGAGAGAGACAGACACGATGGATACCTTTGTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCACACAGCCCTTT
TAACACAGCAGTGGCCGATTACTGGATGCCTGTGGATTTGTACATTGGAGGGAAAGAACATGCCGTCATGCACTTGTTCTATGCAAGATT
CTTTAGTCATTTTTGCCATGATCAAAAAATGGTTAAACATAGCAAATGAAGCTCGTGACCGAGAACCTGAAGGAGGAACCAATGGAAAGC
GGGAAGGAGAAGGCAACCTGAGTGCCCAGCGTGCCCAGCTGCCCTGTTGGCAGAGGCCTGTGTCTGTGCCACACCTGCCACGGTGGCAGG
GGGGGTACCCGGGGCAGCATCGTGGCTCCTGAACCCAGACCCAATGCTTAGCCAAACGAAGTGGCTCCCATGTGGCAAGCACCCTTCTCA
GTTTCGCAGTGGCTTGGCTCGGGATCCTTGGCAGTTCCCCCAGCCCCACCCTGTCTGCTCCTTCCCAGTTCCTTCCCGGGCCCCACACGC
TGCTCCAGCTGCCAACTTTGCTGCAGAGCCACTGCCGCCCTTGAGCCTCTCACCATGAGTGAGCCACCAGCTCTCCACGTTCCCCTCATA
GCAGTGTCACTCCCAACCCCACCATGGCCCAGGGACCCGTGGACAGGTTGGGGATGGGGTGTGTGCCCACTGTGCTCATCACAGGAGCCT
CAGTTGAGAGTGAGCGGGGTACAGTAAGGCAGTGCTTCCCACACTGGACCTCTTTCCTGGTTCTCTTTTGCAATACATTAACAGACCCTT
TATCAACATAAACAATAGTAACTGAGCTATTAAAGGCAACCTCTCTGACTCCTTCTGCCTACATAGGTACCGCAATGGGCTTCCCTTTTC
TGAAGCACTTGGTGAGGTCACTGAAGGTGGAGCGGTGAGATCAGGAGCCCAGGGTGAGGGGCTTGGCTGGAGGCCAGGCACCAAAGCTTG
TAGCTGAAGGCTGGGCCATTTTTGAGAACTGCTGCTGGTGGTGCCCACCTACAGGGACACTAGGGCTGCTTTCACATGCAGGGTGTACCC
ATGGTGCCAAGCCAAGGGCCAGCAGCCACTCCTGGTGCCCTGGCCTGGGCTTGGGCTTGCAGAGAAAAGGGCCCTCCTTGCCCAGTGGTG
CTGCCCACCTCCCTAGCTGTGTCCATGGACTGCCCTGCATTCACAGGCACAAGAATGCCATGTAGGCCAGTGCTGCCCACGTATACAGCC

>In-frame_LARS2_ENST00000265537_chr3_45542071_+_ANO10_ENST00000396091_chr3_43408466_-_2638nt
GTTGCTCTCCTCCCTTCCCCGGTCCCGCCCCCGTCTGTCTGTGTCGACTGCGGACGCTATCGATAAAGTTGCTGTTTTGACAACATGGCG
GCGCCCATGGTCCGTGGCCCGGCAGTGCTCGCCTAAAGGTGGAGAACGAGGAGTAGAGGAGCCGCAGGCCAGAGCCTGTGAGCAGATCCA
GACCTACAGATAAAAAACATTATTTAATCTATCTGGGATTTACTCCGGCTTATGATTTGAGGGCCTTCTCACCTTCTGAAGAATGGCTTC
TGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAAT
TCCCGGATGTACCAGAAGCATCTACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAGAAATGGTG
GCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTACGTGCTTTCCATGTTCCCTTATCC
TTCTGGTAAGCTGCACATGGGCCATGTGCGTGTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATGCAGGTCAT
CAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAGTAA
TATTAAACACATGAGGAAACAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGCCAGATTACTACAA
GTGGACTCAGTATCTCTTTATTAAACTGTATGAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTTAACTGGGACCCAGTGGATCAAAC
AGTGCTTGCCAATGAGCAGGTGGATGAACATGGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGACAATGGTTTAT
TAAGACAACCGCTTATGCAAAGGCCATGCAGGACGCGTTGGCAGACCTTCCAGAATGGTATGGAATAAAAGGCATGCAAGCCCACTGGAT
TGGGGACTGTGTGGGCTGCCACCTGGACTTCACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTATACGGCCACCCC
TGAAGCCATTTATGGCACCTCCCACGTGGCCATCTCGCCCAGCCACAGACTCCTACATGGGCACAGCTCTCTGAAGGAAGCCTTGAGGAT
GGCCCTTGTCCCTGGCAAAGATTGCCTCACGCCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTTATTTTGGCCAA
AGCTGACTTGGAAGGCTCTCTGGATTCAAAAATAGGAATTCCCAGTACTAGCTCAGAGGACACCATCTTAGCCCAAACCCTGGGCCTGGC
CTACTCTGAAGTCATTGAAACTTTGCCAGATGGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCCGGCAGGATGCTTT
TCTAGCCCTGACTCAGAAAGCCCGGGGGAAGAGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAAGACTGGCTGATTTCACGGCAGCG
GTACTGGGGCACACCAATCCCCATTGTCCACTGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTGACCCTGCCCAA
CATCGCGTCTTTCACTGGCAAGGGAGGCCCCCCACTGGCCATGGCTTCAGAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAGGGAGCAGC
CAAGAGAGAGACAGACACGATGGATACCTTTGTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCACACAGCCCTTT
TAACACAGCAGTGGCCGATTACTGGATGCCTGTGGATTTGTACATTGGAGGGAAAGAACATGCCGTCATGCACTTGTTCTATGCAAGATT
CTTTAGTCATTTTTGCCATGATCAAAAAATGGTTAAACATAGCAAATGAAGCTCGTGACCGAGAACCTGAAGGAGGAACCAATGGAAAGC
GGGAAGGAGAAGGCAACCTGAGTGCCCAGCGTGCCCAGCTGCCCTGTTGGCAGAGGCCTGTGTCTGTGCCACACCTGCCACGGTGGCAGG
GGGGGTACCCGGGGCAGCATCGTGGCTCCTGAACCCAGACCCAATGCTTAGCCAAACGAAGTGGCTCCCATGTGGCAAGCACCCTTCTCA
GTTTCGCAGTGGCTTGGCTCGGGATCCTTGGCAGTTCCCCCAGCCCCACCCTGTCTGCTCCTTCCCAGTTCCTTCCCGGGCCCCACACGC
TGCTCCAGCTGCCAACTTTGCTGCAGAGCCACTGCCGCCCTTGAGCCTCTCACCATGAGTGAGCCACCAGCTCTCCACGTTCCCCTCATA
GCAGTGTCACTCCCAACCCCACCATGGCCCAGGGACCCGTGGACAGGTTGGGGATGGGGTGTGTGCCCACTGTGCTCATCACAGGAGCCT
CAGTTGAGAGTGAGCGGGGTACAGTAAGGCAGTGCTTCCCACACTGGACCTCTTTCCTGGTTCTCTTTTGCAATACATTAACAGACCCTT

>In-frame_LARS2_ENST00000415258_chr3_45542071_+_ANO10_ENST00000292246_chr3_43408466_-_3028nt
GCTATCGATAAAGTTGCTGTTTTGACAACATGGCGGCGCCCATGGTCCGTGGCCCGGCAGTGCTCGCCTAAAGGTGGAGAACGAGGAGTA
GAGGAGCCGCAGGCCAGAGCCTGTGAGCAGGGCCTTCTCACCTTCTGAAGAATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCT
CTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCC
ACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAGAAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAA
ATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTACGTGCTTTCCATGTTCCCTTATCCTTCTGGTAAGCTGCACATGGGCCATGTGCGT
GTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATGCAGGTCATCAACCCCATGGGATGGGATGCTTTTGGATTG
CCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGT
CTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGCCAGATTACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTAT
GAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTTAACTGGGACCCAGTGGATCAAACAGTGCTTGCCAATGAGCAGGTGGATGAACAT
GGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGACAATGGTTTATTAAGACAACCGCTTATGCAAAGGCCATGCAG
GACGCGTTGGCAGACCTTCCAGAATGGTATGGAATAAAAGGCATGCAAGCCCACTGGATTGGGGACTGTGTGGGCTGCCACCTGGACTTC
ACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTATACGGCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCC
ATCTCGCCCAGCCACAGACTCCTACATGGGCACAGCTCTCTGAAGGAAGCCTTGAGGATGGCCCTTGTCCCTGGCAAAGATTGCCTCACG
CCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTTATTTTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAA
ATAGGAATTCCCAGTACTAGCTCAGAGGACACCATCTTAGCCCAAACCCTGGGCCTGGCCTACTCTGAAGTCATTGAAACTTTGCCAGAT
GGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCCGGCAGGATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAG
AGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAAGACTGGCTGATTTCACGGCAGCGGTACTGGGGCACACCAATCCCCATTGTCCAC
TGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTGACCCTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCC
CCACTGGCCATGGCTTCAGAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAGGGAGCAGCCAAGAGAGAGACAGACACGATGGATACCTTT
GTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCACACAGCCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCT
GTGGATTTGTACATTGGAGGGAAAGAACATGCCGTCATGCACTTGTTCTATGCAAGATTCTTTAGTCATTTTTGCCATGATCAAAAAATG
GTTAAACATAGCAAATGAAGCTCGTGACCGAGAACCTGAAGGAGGAACCAATGGAAAGCGGGAAGGAGAAGGCAACCTGAGTGCCCAGCG
TGCCCAGCTGCCCTGTTGGCAGAGGCCTGTGTCTGTGCCACACCTGCCACGGTGGCAGGGGGGGTACCCGGGGCAGCATCGTGGCTCCTG
AACCCAGACCCAATGCTTAGCCAAACGAAGTGGCTCCCATGTGGCAAGCACCCTTCTCAGTTTCGCAGTGGCTTGGCTCGGGATCCTTGG
CAGTTCCCCCAGCCCCACCCTGTCTGCTCCTTCCCAGTTCCTTCCCGGGCCCCACACGCTGCTCCAGCTGCCAACTTTGCTGCAGAGCCA
CTGCCGCCCTTGAGCCTCTCACCATGAGTGAGCCACCAGCTCTCCACGTTCCCCTCATAGCAGTGTCACTCCCAACCCCACCATGGCCCA
GGGACCCGTGGACAGGTTGGGGATGGGGTGTGTGCCCACTGTGCTCATCACAGGAGCCTCAGTTGAGAGTGAGCGGGGTACAGTAAGGCA
GTGCTTCCCACACTGGACCTCTTTCCTGGTTCTCTTTTGCAATACATTAACAGACCCTTTATCAACATAAACAATAGTAACTGAGCTATT
AAAGGCAACCTCTCTGACTCCTTCTGCCTACATAGGTACCGCAATGGGCTTCCCTTTTCTGAAGCACTTGGTGAGGTCACTGAAGGTGGA
GCGGTGAGATCAGGAGCCCAGGGTGAGGGGCTTGGCTGGAGGCCAGGCACCAAAGCTTGTAGCTGAAGGCTGGGCCATTTTTGAGAACTG
CTGCTGGTGGTGCCCACCTACAGGGACACTAGGGCTGCTTTCACATGCAGGGTGTACCCATGGTGCCAAGCCAAGGGCCAGCAGCCACTC
CTGGTGCCCTGGCCTGGGCTTGGGCTTGCAGAGAAAAGGGCCCTCCTTGCCCAGTGGTGCTGCCCACCTCCCTAGCTGTGTCCATGGACT
GCCCTGCATTCACAGGCACAAGAATGCCATGTAGGCCAGTGCTGCCCACGTATACAGCCCTTCCCACCAGCGCTGGCCGTCCTGCTGTAG

>In-frame_LARS2_ENST00000415258_chr3_45542071_+_ANO10_ENST00000396091_chr3_43408466_-_2517nt
GCTATCGATAAAGTTGCTGTTTTGACAACATGGCGGCGCCCATGGTCCGTGGCCCGGCAGTGCTCGCCTAAAGGTGGAGAACGAGGAGTA
GAGGAGCCGCAGGCCAGAGCCTGTGAGCAGGGCCTTCTCACCTTCTGAAGAATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCT
CTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCC
ACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAGAAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAA
ATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTACGTGCTTTCCATGTTCCCTTATCCTTCTGGTAAGCTGCACATGGGCCATGTGCGT
GTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATGCAGGTCATCAACCCCATGGGATGGGATGCTTTTGGATTG
CCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGT
CTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGCCAGATTACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTAT
GAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTTAACTGGGACCCAGTGGATCAAACAGTGCTTGCCAATGAGCAGGTGGATGAACAT
GGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGACAATGGTTTATTAAGACAACCGCTTATGCAAAGGCCATGCAG
GACGCGTTGGCAGACCTTCCAGAATGGTATGGAATAAAAGGCATGCAAGCCCACTGGATTGGGGACTGTGTGGGCTGCCACCTGGACTTC
ACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTATACGGCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCC
ATCTCGCCCAGCCACAGACTCCTACATGGGCACAGCTCTCTGAAGGAAGCCTTGAGGATGGCCCTTGTCCCTGGCAAAGATTGCCTCACG
CCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTTATTTTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAA
ATAGGAATTCCCAGTACTAGCTCAGAGGACACCATCTTAGCCCAAACCCTGGGCCTGGCCTACTCTGAAGTCATTGAAACTTTGCCAGAT
GGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCCGGCAGGATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAG
AGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAAGACTGGCTGATTTCACGGCAGCGGTACTGGGGCACACCAATCCCCATTGTCCAC
TGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTGACCCTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCC
CCACTGGCCATGGCTTCAGAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAGGGAGCAGCCAAGAGAGAGACAGACACGATGGATACCTTT
GTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCACACAGCCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCT
GTGGATTTGTACATTGGAGGGAAAGAACATGCCGTCATGCACTTGTTCTATGCAAGATTCTTTAGTCATTTTTGCCATGATCAAAAAATG
GTTAAACATAGCAAATGAAGCTCGTGACCGAGAACCTGAAGGAGGAACCAATGGAAAGCGGGAAGGAGAAGGCAACCTGAGTGCCCAGCG
TGCCCAGCTGCCCTGTTGGCAGAGGCCTGTGTCTGTGCCACACCTGCCACGGTGGCAGGGGGGGTACCCGGGGCAGCATCGTGGCTCCTG
AACCCAGACCCAATGCTTAGCCAAACGAAGTGGCTCCCATGTGGCAAGCACCCTTCTCAGTTTCGCAGTGGCTTGGCTCGGGATCCTTGG
CAGTTCCCCCAGCCCCACCCTGTCTGCTCCTTCCCAGTTCCTTCCCGGGCCCCACACGCTGCTCCAGCTGCCAACTTTGCTGCAGAGCCA
CTGCCGCCCTTGAGCCTCTCACCATGAGTGAGCCACCAGCTCTCCACGTTCCCCTCATAGCAGTGTCACTCCCAACCCCACCATGGCCCA
GGGACCCGTGGACAGGTTGGGGATGGGGTGTGTGCCCACTGTGCTCATCACAGGAGCCTCAGTTGAGAGTGAGCGGGGTACAGTAAGGCA

>In-frame_LARS2_ENST00000414984_chr3_45542071_+_ANO10_ENST00000292246_chr3_43408466_-_2896nt
ATCGATAAAGTTGCTGTTTTGACAACATGGCGGCGCCCATGGTCCGTGGCCCGGCAGTGCTCGCCTAAAGGTGGAGAACGAGGAGTAGAG
GAGCCGCAGGCCAGAGCCTGTGAGCAGGGCCTTCTCACCTTCTGAAGAATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTT
CTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCCACG
GGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAGAAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATT
TCAGAAGCTGATGTCATCAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAA
AGTTGGACACAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGT
TTGCCAGATTACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTATGAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTTAACTGG
GACCCAGTGGATCAAACAGTGCTTGCCAATGAGCAGGTGGATGAACATGGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTAC
CTCAGACAATGGTTTATTAAGACAACCGCTTATGCAAAGGCCATGCAGGACGCGTTGGCAGACCTTCCAGAATGGTATGGAATAAAAGGC
ATGCAAGCCCACTGGATTGGGGACTGTGTGGGCTGCCACCTGGACTTCACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACT
GCCTATACGGCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCCATCTCGCCCAGCCACAGACTCCTACATGGGCACAGCTCTCTG
AAGGAAGCCTTGAGGATGGCCCTTGTCCCTGGCAAAGATTGCCTCACGCCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCT
GTCGTTATTTTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAAATAGGAATTCCCAGTACTAGCTCAGAGGACACCATCTTAGCC
CAAACCCTGGGCCTGGCCTACTCTGAAGTCATTGAAACTTTGCCAGATGGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATG
ACCCGGCAGGATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAGAGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAAGACTGG
CTGATTTCACGGCAGCGGTACTGGGGCACACCAATCCCCATTGTCCACTGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTG
CCTGTGACCCTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCCCCACTGGCCATGGCTTCAGAGTGGGTGAACTGCTCCTGCCCA
AGGTGCAAGGGAGCAGCCAAGAGAGAGACAGACACGATGGATACCTTTGTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCAT
AATCCACACAGCCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCTGTGGATTTGTACATTGGAGGGAAAGAACATGCCGTCATGCAC
TTGTTCTATGCAAGATTCTTTAGTCATTTTTGCCATGATCAAAAAATGGTTAAACATAGCAAATGAAGCTCGTGACCGAGAACCTGAAGG
AGGAACCAATGGAAAGCGGGAAGGAGAAGGCAACCTGAGTGCCCAGCGTGCCCAGCTGCCCTGTTGGCAGAGGCCTGTGTCTGTGCCACA
CCTGCCACGGTGGCAGGGGGGGTACCCGGGGCAGCATCGTGGCTCCTGAACCCAGACCCAATGCTTAGCCAAACGAAGTGGCTCCCATGT
GGCAAGCACCCTTCTCAGTTTCGCAGTGGCTTGGCTCGGGATCCTTGGCAGTTCCCCCAGCCCCACCCTGTCTGCTCCTTCCCAGTTCCT
TCCCGGGCCCCACACGCTGCTCCAGCTGCCAACTTTGCTGCAGAGCCACTGCCGCCCTTGAGCCTCTCACCATGAGTGAGCCACCAGCTC
TCCACGTTCCCCTCATAGCAGTGTCACTCCCAACCCCACCATGGCCCAGGGACCCGTGGACAGGTTGGGGATGGGGTGTGTGCCCACTGT
GCTCATCACAGGAGCCTCAGTTGAGAGTGAGCGGGGTACAGTAAGGCAGTGCTTCCCACACTGGACCTCTTTCCTGGTTCTCTTTTGCAA
TACATTAACAGACCCTTTATCAACATAAACAATAGTAACTGAGCTATTAAAGGCAACCTCTCTGACTCCTTCTGCCTACATAGGTACCGC
AATGGGCTTCCCTTTTCTGAAGCACTTGGTGAGGTCACTGAAGGTGGAGCGGTGAGATCAGGAGCCCAGGGTGAGGGGCTTGGCTGGAGG
CCAGGCACCAAAGCTTGTAGCTGAAGGCTGGGCCATTTTTGAGAACTGCTGCTGGTGGTGCCCACCTACAGGGACACTAGGGCTGCTTTC
ACATGCAGGGTGTACCCATGGTGCCAAGCCAAGGGCCAGCAGCCACTCCTGGTGCCCTGGCCTGGGCTTGGGCTTGCAGAGAAAAGGGCC
CTCCTTGCCCAGTGGTGCTGCCCACCTCCCTAGCTGTGTCCATGGACTGCCCTGCATTCACAGGCACAAGAATGCCATGTAGGCCAGTGC
TGCCCACGTATACAGCCCTTCCCACCAGCGCTGGCCGTCCTGCTGTAGCCAAGACACTACAGACCCGTGGGCACCTCCACTCGGACAGCA

>In-frame_LARS2_ENST00000414984_chr3_45542071_+_ANO10_ENST00000396091_chr3_43408466_-_2385nt
ATCGATAAAGTTGCTGTTTTGACAACATGGCGGCGCCCATGGTCCGTGGCCCGGCAGTGCTCGCCTAAAGGTGGAGAACGAGGAGTAGAG
GAGCCGCAGGCCAGAGCCTGTGAGCAGGGCCTTCTCACCTTCTGAAGAATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTT
CTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCCACG
GGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAGAAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATT
TCAGAAGCTGATGTCATCAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAA
AGTTGGACACAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGT
TTGCCAGATTACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTATGAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTTAACTGG
GACCCAGTGGATCAAACAGTGCTTGCCAATGAGCAGGTGGATGAACATGGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTAC
CTCAGACAATGGTTTATTAAGACAACCGCTTATGCAAAGGCCATGCAGGACGCGTTGGCAGACCTTCCAGAATGGTATGGAATAAAAGGC
ATGCAAGCCCACTGGATTGGGGACTGTGTGGGCTGCCACCTGGACTTCACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACT
GCCTATACGGCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCCATCTCGCCCAGCCACAGACTCCTACATGGGCACAGCTCTCTG
AAGGAAGCCTTGAGGATGGCCCTTGTCCCTGGCAAAGATTGCCTCACGCCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCT
GTCGTTATTTTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAAATAGGAATTCCCAGTACTAGCTCAGAGGACACCATCTTAGCC
CAAACCCTGGGCCTGGCCTACTCTGAAGTCATTGAAACTTTGCCAGATGGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATG
ACCCGGCAGGATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAGAGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAAGACTGG
CTGATTTCACGGCAGCGGTACTGGGGCACACCAATCCCCATTGTCCACTGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTG
CCTGTGACCCTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCCCCACTGGCCATGGCTTCAGAGTGGGTGAACTGCTCCTGCCCA
AGGTGCAAGGGAGCAGCCAAGAGAGAGACAGACACGATGGATACCTTTGTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCAT
AATCCACACAGCCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCTGTGGATTTGTACATTGGAGGGAAAGAACATGCCGTCATGCAC
TTGTTCTATGCAAGATTCTTTAGTCATTTTTGCCATGATCAAAAAATGGTTAAACATAGCAAATGAAGCTCGTGACCGAGAACCTGAAGG
AGGAACCAATGGAAAGCGGGAAGGAGAAGGCAACCTGAGTGCCCAGCGTGCCCAGCTGCCCTGTTGGCAGAGGCCTGTGTCTGTGCCACA
CCTGCCACGGTGGCAGGGGGGGTACCCGGGGCAGCATCGTGGCTCCTGAACCCAGACCCAATGCTTAGCCAAACGAAGTGGCTCCCATGT
GGCAAGCACCCTTCTCAGTTTCGCAGTGGCTTGGCTCGGGATCCTTGGCAGTTCCCCCAGCCCCACCCTGTCTGCTCCTTCCCAGTTCCT
TCCCGGGCCCCACACGCTGCTCCAGCTGCCAACTTTGCTGCAGAGCCACTGCCGCCCTTGAGCCTCTCACCATGAGTGAGCCACCAGCTC
TCCACGTTCCCCTCATAGCAGTGTCACTCCCAACCCCACCATGGCCCAGGGACCCGTGGACAGGTTGGGGATGGGGTGTGTGCCCACTGT
GCTCATCACAGGAGCCTCAGTTGAGAGTGAGCGGGGTACAGTAAGGCAGTGCTTCCCACACTGGACCTCTTTCCTGGTTCTCTTTTGCAA


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FusionGenePPI for LARS2_ANO10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LARS2YWHAQ, BSG, TGOLN2, FBXW11, NTRK1, RHOU, DUSP22, NIT1, NDUFS7, YBEY, ACSM5, BPNT1, MRPL21, C1orf85, ATP5D, SUCLG1, BCKDHB, ACAA2, LIG3, SDHBANO10TCTN2, TMEM216, SLC17A2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LARS2_ANO10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LARS2_ANO10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLARS2C3809105PERRAULT SYNDROME 42UNIPROT
HgeneLARS2C0005586Bipolar Disorder1PSYGENET
HgeneLARS2C0036341Schizophrenia1PSYGENET
TgeneANO10C3150998SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 101ORPHANET;UNIPROT