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Fusion gene ID: 19470 |
FusionGeneSummary for LARP4B_IDI2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LARP4B_IDI2 | Fusion gene ID: 19470 | Hgene | Tgene | Gene symbol | LARP4B | IDI2 | Gene ID | 23185 | 91734 |
| Gene name | La ribonucleoprotein domain family member 4B | isopentenyl-diphosphate delta isomerase 2 | |
| Synonyms | KIAA0217|LARP5 | IPPI2 | |
| Cytomap | 10p15.3 | 10p15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | la-related protein 4BLa ribonucleoprotein domain family, member 5la-related protein 5 | isopentenyl-diphosphate delta-isomerase 2IPP isomerase 2diphosphate dimethylallyl diphosphate isomerase 2isopentenyl pyrophosphate isomerase 2isopentenyl-diphosphate Delta-isomerase 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q92615 | Q9BXS1 | |
| Ensembl transtripts involved in fusion gene | ENST00000316157, ENST00000469487, | ENST00000277517, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: LARP4B [Title/Abstract] AND IDI2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IDI2 | GO:0008299 | isoprenoid biosynthetic process | 17202134 |
| Tgene | IDI2 | GO:0046490 | isopentenyl diphosphate metabolic process | 17202134 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-49-4488-01A | LARP4B | chr10 | 882345 | - | IDI2 | chr10 | 1071799 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000316157 | ENST00000277517 | LARP4B | chr10 | 882345 | - | IDI2 | chr10 | 1071799 | - |
| intron-3CDS | ENST00000469487 | ENST00000277517 | LARP4B | chr10 | 882345 | - | IDI2 | chr10 | 1071799 | - |
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FusionProtFeatures for LARP4B_IDI2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LARP4B | IDI2 |
| Stimulates mRNA translation.{ECO:0000269|PubMed:20573744}. | Catalyzes the 1,3-allylic rearrangement of thehomoallylic substrate isopentenyl (IPP) to its highlyelectrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).{ECO:0000269|PubMed:17202134}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LARP4B | chr10:882345 | chr10:1071799 | ENST00000316157 | - | 7 | 17 | 150_239 | 250 | 739 | Domain | HTH La-type RNA-binding |
| Tgene | >IDI2 | chr10:882345 | chr10:1071799 | ENST00000277517 | - | -1 | 5 | 49_199 | -7 | 228 | Domain | Nudix hydrolase |
| Tgene | >IDI2 | chr10:882345 | chr10:1071799 | ENST00000277517 | - | -1 | 5 | 225_227 | -7 | 228 | Motif | Microbody targeting signal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LARP4B | chr10:882345 | chr10:1071799 | ENST00000316157 | - | 7 | 17 | 240_307 | 250 | 739 | Domain | Note=RRM |
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FusionGeneSequence for LARP4B_IDI2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LARP4B_ENST00000316157_chr10_882345_-_IDI2_ENST00000277517_chr10_1071799_-_250aa MTSDQDAKVVAEPQTQRVQEGKDSAHLMNGPISQTTSQTSSIPPLSQVPATKVSELNPNAEVWGAPVLHLEASSAADGVSAAWEEVAGHH ADRGPQGSDANGDGDQGHENAALPDPQESDPADMNALALGPSEYDSLPENSETGGNESQPDSQEDPREVLKKTLEFCLSRENLASDMYLI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LARP4B_ENST00000316157_chr10_882345_-_IDI2_ENST00000277517_chr10_1071799_-_750nt ATGACTTCTGATCAGGACGCTAAGGTTGTGGCTGAACCGCAGACGCAGAGAGTCCAGGAGGGCAAGGACAGCGCTCATCTGATGAATGGT CCTATATCTCAAACCACTTCTCAGACAAGTTCCATCCCACCTTTGAGTCAGGTACCAGCAACTAAGGTTTCAGAGCTGAACCCTAATGCA GAAGTGTGGGGGGCTCCTGTGTTACATCTGGAAGCAAGCAGTGCTGCTGACGGTGTGAGTGCTGCATGGGAGGAGGTGGCTGGCCACCAC GCAGACCGTGGCCCGCAGGGATCGGATGCCAATGGTGATGGTGACCAGGGCCATGAGAATGCCGCATTGCCAGACCCGCAGGAGTCGGAC CCAGCAGACATGAACGCTCTCGCTCTGGGTCCCTCAGAATATGACTCTCTGCCTGAAAATAGCGAGACAGGAGGAAATGAGTCTCAACCA GACAGCCAGGAAGACCCCCGAGAAGTACTTAAAAAAACATTGGAATTCTGCTTATCTAGGGAGAACCTTGCTAGTGACATGTATCTTATA TCACAGATGGATAGTGACCAGTATGTGCCAATCACAACGGTGGCTAACCTCGACCACATCAAGAAGCTCAGCACTGATGTGGACTTGATT GTGGAAGTGCTAAGATCTTTACCTTTAGTCCAAGTGGATGAAAAGGGAGAAAAAGTAAGGCCAAATCAAAATCGCTGCATAGTAATATTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LARP4B_ENST00000316157_chr10_882345_-_IDI2_ENST00000277517_chr10_1071799_-_2150nt AGCATCCTGAGGTTAGCATTACACTTCTCCCAGTGGAGCCCATGACTTCTGATCAGGACGCTAAGGTTGTGGCTGAACCGCAGACGCAGA GAGTCCAGGAGGGCAAGGACAGCGCTCATCTGATGAATGGTCCTATATCTCAAACCACTTCTCAGACAAGTTCCATCCCACCTTTGAGTC AGGTACCAGCAACTAAGGTTTCAGAGCTGAACCCTAATGCAGAAGTGTGGGGGGCTCCTGTGTTACATCTGGAAGCAAGCAGTGCTGCTG ACGGTGTGAGTGCTGCATGGGAGGAGGTGGCTGGCCACCACGCAGACCGTGGCCCGCAGGGATCGGATGCCAATGGTGATGGTGACCAGG GCCATGAGAATGCCGCATTGCCAGACCCGCAGGAGTCGGACCCAGCAGACATGAACGCTCTCGCTCTGGGTCCCTCAGAATATGACTCTC TGCCTGAAAATAGCGAGACAGGAGGAAATGAGTCTCAACCAGACAGCCAGGAAGACCCCCGAGAAGTACTTAAAAAAACATTGGAATTCT GCTTATCTAGGGAGAACCTTGCTAGTGACATGTATCTTATATCACAGATGGATAGTGACCAGTATGTGCCAATCACAACGGTGGCTAACC TCGACCACATCAAGAAGCTCAGCACTGATGTGGACTTGATTGTGGAAGTGCTAAGATCTTTACCTTTAGTCCAAGTGGATGAAAAGGGAG AAAAAGTAAGGCCAAATCAAAATCGCTGCATAGTAATATTGCGTGAAATATCTGAATCTACCCCCGTGGAAGAGTTCCACATCTGATACC CAGGAGTCTCCAGCTTCCAAGAGAGGTCGGGTCACAGCCAGCAGCTATGTCTGACATAAATCTTGACTGGGTTGACAGGCGTCAGTTGCA GCGCTTGGAGGAAATGCTGATTGTTGTGGATGAGAATGATAAGGTTATTGGTGCCGACACCAAGAGGAATTGCCATCTGAACGAAAACAT TGAGAAAGGGCTGCTGCACCGAGCCTTCAGCGTTGTCTTGTTTAACACCAAGAATCGAATCCTGATACAGCAGAGGTCGGACACGAAAGT CACGTTTCCTGGGTATTTTACCGACTCCTGTAGTAGCCACCCATTATACAACCCAGCAGAACTGGAAGAAAAGGATGCCATCGGAGTGAG GAGGGCAGCCCAGAGGCGTCTGCAAGCAGAGCTGGGAATTCCTGGGGAGCAGATTTCTCCAGAGGACATTGTGTTCATGACAATCTATCA CCACAAGGCAAAATCAGACAGAATTTGGGGAGAGCATGAAATTTGTTACCTTCTGCTTGTGAGGAAAAACGTCACTCTGAACCCGGATCC CAGTGAAACGAAAAGCATCCTCTACCTGTCCCAGGAGGAGCTGTGGGAGCTGCTGGAGAGGGAGGCGAGGGGTGAAGTCAAAGTCACCCC CTGGCTAAGAACCATTGCCGAGAGGTTTCTGTACCGGTGGTGGCCTCACCTGGATGACGTGACCCCGTTTGTGGAGCTTCACAAAATACA CAGAGTGTGAGAGGCAGGGAGGTCGAGTCAGCCATGTGTAATGCCCTCAGTGCAGGCAGACGCACCATTGAGGCAATGATACACCCTCTC CAAAAAACAGGGCAAAAGGGGCACTTGATTGCCCATCATGTATAAATCACTATTTCAACCTTTTCATCAACTTTGTCATATCTTCATTTT CCCTTTTCCTTATTTCCATATTTCTCATCTGCCTGGTTGCAGGGAGGAAATTTAACATTTCCTTTGTCCCAATTTCCATTTTATAAGCAC TTGTTTGATTAACAGCAGCTGATCCTGAAAGTCTTGGGGAGATCTTGAGAGTCCTGAAGCAGGCGGACTAGCCTGGCTGGACCATGAGGC TGTCTCCCCACAGCTTTATCCAAGCCTCCAAGGTCAGGATGGGATCTCTGTATCATGTTTTTCTTTTTAAATCACTTATTTCAGAGTGCA ACACAAGGCTGCATTTTTAAAAAAAAGACACATTCAATCTTGCATCCTAATACAAGCAGTACGGAAGATGCGTATGGTCTCAGCCAAGTG |
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FusionGenePPI for LARP4B_IDI2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LARP4B | GNB2L1, ELAVL1, SIRT7, CUL3, COPS5, CDV3, HSP90AA1, MMS19, CDK18, HECW2, LIN28A, FHL3, RBFOX2, NTRK1, IFI16, XPO1, NPM1, RPL10, STRAP, FAM136A, ASB3, IL13RA2, TRIM25 | IDI2 | BCL6, LDB1, ISL2, SSBP2, SSBP4, SSBP3, LMO4, LMX1B, FAM76B, TRIM27, RABL2B, RNF114 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LARP4B_IDI2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LARP4B_IDI2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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