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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19451

FusionGeneSummary for LAPTM5_CD82

check button Fusion gene summary
Fusion gene informationFusion gene name: LAPTM5_CD82
Fusion gene ID: 19451
HgeneTgene
Gene symbol

LAPTM5

CD82

Gene ID

7805

3732

Gene namelysosomal protein transmembrane 5CD82 molecule
SynonymsCLAST64F9|C33|GR15|IA4|KAI1|R2|SAR2|ST6|TSPAN27
Cytomap

1p35.2

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionlysosomal-associated transmembrane protein 5CD40-ligand-activated specific transcriptshuman retinoic acid-inducible E3 proteinlysosomal associated multispanning membrane protein 5lysosomal multispanning membrane protein 5lysosomal-associated multitraCD82 antigenC33 antigeninducible membrane protein R2kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))metastasis suppressor Kangai-1tetraspanin-27tspan-27
Modification date2018052320180523
UniProtAcc

Q13571

P27701

Ensembl transtripts involved in fusion geneENST00000294507, ENST00000476492, 
ENST00000227155, ENST00000342935, 
ENST00000530931, 
Fusion gene scores* DoF score4 X 4 X 1=165 X 3 X 4=60
# samples 45
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LAPTM5 [Title/Abstract] AND CD82 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI024399LAPTM5chr1

31221182

-CD82chr11

44597472

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000294507ENST00000227155LAPTM5chr1

31221182

-CD82chr11

44597472

+
intron-intronENST00000294507ENST00000342935LAPTM5chr1

31221182

-CD82chr11

44597472

+
intron-intronENST00000294507ENST00000530931LAPTM5chr1

31221182

-CD82chr11

44597472

+
intron-intronENST00000476492ENST00000227155LAPTM5chr1

31221182

-CD82chr11

44597472

+
intron-intronENST00000476492ENST00000342935LAPTM5chr1

31221182

-CD82chr11

44597472

+
intron-intronENST00000476492ENST00000530931LAPTM5chr1

31221182

-CD82chr11

44597472

+

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FusionProtFeatures for LAPTM5_CD82


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAPTM5

Q13571

CD82

P27701

May have a special functional role during embryogenesisand in adult hematopoietic cells. {ECO:0000269|PubMed:8661146}. Associates with CD4 or CD8 and delivers costimulatorysignals for the TCR/CD3 pathway.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAPTM5_CD82


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAPTM5_CD82


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAPTM5_CD82


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAPTM5_CD82


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAPTM5C0017661IGA Glomerulonephritis1CTD_human
HgeneLAPTM5C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCD82C0000786Spontaneous abortion1CTD_human
TgeneCD82C0027626Neoplasm Invasiveness1CTD_human
TgeneCD82C0027627Neoplasm Metastasis1CTD_human