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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19450

FusionGeneSummary for LAPTM5_AFAP1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: LAPTM5_AFAP1L1
Fusion gene ID: 19450
HgeneTgene
Gene symbol

LAPTM5

AFAP1L1

Gene ID

7805

134265

Gene namelysosomal protein transmembrane 5actin filament associated protein 1 like 1
SynonymsCLAST6-
Cytomap

1p35.2

5q32

Type of geneprotein-codingprotein-coding
Descriptionlysosomal-associated transmembrane protein 5CD40-ligand-activated specific transcriptshuman retinoic acid-inducible E3 proteinlysosomal associated multispanning membrane protein 5lysosomal multispanning membrane protein 5lysosomal-associated multitraactin filament-associated protein 1-like 1AFAP1-like protein 1
Modification date2018052320180519
UniProtAcc

Q13571

Q8TED9

Ensembl transtripts involved in fusion geneENST00000294507, ENST00000476492, 
ENST00000296721, ENST00000522492, 
ENST00000515000, 
Fusion gene scores* DoF score4 X 4 X 1=163 X 3 X 2=18
# samples 43
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LAPTM5 [Title/Abstract] AND AFAP1L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK303314LAPTM5chr1

31208049

-AFAP1L1chr5

148691717

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000294507ENST00000296721LAPTM5chr1

31208049

-AFAP1L1chr5

148691717

+
intron-intronENST00000294507ENST00000522492LAPTM5chr1

31208049

-AFAP1L1chr5

148691717

+
intron-intronENST00000294507ENST00000515000LAPTM5chr1

31208049

-AFAP1L1chr5

148691717

+
intron-3CDSENST00000476492ENST00000296721LAPTM5chr1

31208049

-AFAP1L1chr5

148691717

+
intron-intronENST00000476492ENST00000522492LAPTM5chr1

31208049

-AFAP1L1chr5

148691717

+
intron-intronENST00000476492ENST00000515000LAPTM5chr1

31208049

-AFAP1L1chr5

148691717

+

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FusionProtFeatures for LAPTM5_AFAP1L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAPTM5

Q13571

AFAP1L1

Q8TED9

May have a special functional role during embryogenesisand in adult hematopoietic cells. {ECO:0000269|PubMed:8661146}. May be involved in podosome and invadosome formation.{ECO:0000269|PubMed:21333378}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAPTM5_AFAP1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAPTM5_AFAP1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAPTM5_AFAP1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAPTM5_AFAP1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAPTM5C0017661IGA Glomerulonephritis1CTD_human
HgeneLAPTM5C0023893Liver Cirrhosis, Experimental1CTD_human