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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19441

FusionGeneSummary for LAPTM4A_DHDDS

check button Fusion gene summary
Fusion gene informationFusion gene name: LAPTM4A_DHDDS
Fusion gene ID: 19441
HgeneTgene
Gene symbol

LAPTM4A

DHDDS

Gene ID

9741

79947

Gene namelysosomal protein transmembrane 4 alphadehydrodolichyl diphosphate synthase subunit
SynonymsHUMORF13|LAPTM4|MBNT|MtrpCIT|CPT|DEDSM|DS|HDS|RP59
Cytomap

2p24.1

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionlysosomal-associated transmembrane protein 4Agolgi 4-transmembrane-spanning transporter MTPlysosomal-associated protein transmembrane 4 alphamembrane nucleoside transporterdehydrodolichyl diphosphate synthase complex subunit DHDDScis-IPTasecis-isoprenyltransferasecis-prenyl transferasededol-PP synthasedehydrodolichyl diphosphate syntase complex subunit DHDDSepididymis tissue protein Li 189m
Modification date2018052320180523
UniProtAcc

Q15012

Q86SQ9

Ensembl transtripts involved in fusion geneENST00000175091, ENST00000427245, 
ENST00000525682, ENST00000236342, 
ENST00000526219, ENST00000374185, 
ENST00000360009, ENST00000531955, 
Fusion gene scores* DoF score7 X 6 X 4=1682 X 2 X 2=8
# samples 73
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/8*10)=1.90689059560852
Context

PubMed: LAPTM4A [Title/Abstract] AND DHDDS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV321690LAPTM4Achr2

20247869

+DHDDSchr1

26765919

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000175091ENST00000427245LAPTM4Achr2

20247869

+DHDDSchr1

26765919

+
intron-intronENST00000175091ENST00000525682LAPTM4Achr2

20247869

+DHDDSchr1

26765919

+
intron-intronENST00000175091ENST00000236342LAPTM4Achr2

20247869

+DHDDSchr1

26765919

+
intron-intronENST00000175091ENST00000526219LAPTM4Achr2

20247869

+DHDDSchr1

26765919

+
intron-intronENST00000175091ENST00000374185LAPTM4Achr2

20247869

+DHDDSchr1

26765919

+
intron-intronENST00000175091ENST00000360009LAPTM4Achr2

20247869

+DHDDSchr1

26765919

+
intron-intronENST00000175091ENST00000531955LAPTM4Achr2

20247869

+DHDDSchr1

26765919

+

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FusionProtFeatures for LAPTM4A_DHDDS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAPTM4A

Q15012

DHDDS

Q86SQ9

May function in the transport of nucleosides and/ornucleoside derivatives between the cytosol and the lumen of anintracellular membrane-bound compartment. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAPTM4A_DHDDS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAPTM4A_DHDDS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAPTM4A_DHDDS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAPTM4A_DHDDS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDHDDSC3151227RETINITIS PIGMENTOSA 591UNIPROT