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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19430

FusionGeneSummary for LANCL2_CHODL

check button Fusion gene summary
Fusion gene informationFusion gene name: LANCL2_CHODL
Fusion gene ID: 19430
HgeneTgene
Gene symbol

LANCL2

CHODL

Gene ID

55915

140578

Gene nameLanC like 2chondrolectin
SynonymsGPR69B|TASPC21orf68|MT75|PRED12
Cytomap

7p11.2

21q21.1

Type of geneprotein-codingprotein-coding
DescriptionlanC-like protein 2G protein-coupled receptor 69BLanC (bacterial lantibiotic synthetase component C)-like 2LanC lantibiotic synthetase component C-like 2testis-specific adriamycin sensitivity proteinchondrolectintransmembrane protein MT75
Modification date2018052320180523
UniProtAcc

Q9NS86

Q9H9P2

Ensembl transtripts involved in fusion geneENST00000254770, ENST00000486376, 
ENST00000400128, ENST00000400131, 
ENST00000400135, ENST00000400127, 
ENST00000338326, ENST00000299295, 
ENST00000543733, 
Fusion gene scores* DoF score5 X 4 X 5=1005 X 4 X 4=80
# samples 64
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LANCL2 [Title/Abstract] AND CHODL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLANCL2

GO:0009789

positive regulation of abscisic acid-activated signaling pathway

19667068

HgeneLANCL2

GO:0045892

negative regulation of transcription, DNA-templated

12566319


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-O2-A52N-01ALANCL2chr7

55433922

+CHODLchr21

19628826

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000254770ENST00000400128LANCL2chr7

55433922

+CHODLchr21

19628826

+
5CDS-5UTRENST00000254770ENST00000400131LANCL2chr7

55433922

+CHODLchr21

19628826

+
5CDS-5UTRENST00000254770ENST00000400135LANCL2chr7

55433922

+CHODLchr21

19628826

+
5CDS-5UTRENST00000254770ENST00000400127LANCL2chr7

55433922

+CHODLchr21

19628826

+
5CDS-5UTRENST00000254770ENST00000338326LANCL2chr7

55433922

+CHODLchr21

19628826

+
5CDS-5UTRENST00000254770ENST00000299295LANCL2chr7

55433922

+CHODLchr21

19628826

+
5CDS-5UTRENST00000254770ENST00000543733LANCL2chr7

55433922

+CHODLchr21

19628826

+
intron-5UTRENST00000486376ENST00000400128LANCL2chr7

55433922

+CHODLchr21

19628826

+
intron-5UTRENST00000486376ENST00000400131LANCL2chr7

55433922

+CHODLchr21

19628826

+
intron-5UTRENST00000486376ENST00000400135LANCL2chr7

55433922

+CHODLchr21

19628826

+
intron-5UTRENST00000486376ENST00000400127LANCL2chr7

55433922

+CHODLchr21

19628826

+
intron-5UTRENST00000486376ENST00000338326LANCL2chr7

55433922

+CHODLchr21

19628826

+
intron-5UTRENST00000486376ENST00000299295LANCL2chr7

55433922

+CHODLchr21

19628826

+
intron-5UTRENST00000486376ENST00000543733LANCL2chr7

55433922

+CHODLchr21

19628826

+

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FusionProtFeatures for LANCL2_CHODL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LANCL2

Q9NS86

CHODL

Q9H9P2

Necessary for abscisic acid (ABA) binding on the cellmembrane and activation of the ABA signaling pathway ingranulocytes. {ECO:0000269|PubMed:19667068}. May play a role in the development of the nervous systemsuch as in neurite outgrowth and elongation. May be involved inmotor axon growth and guidance. {ECO:0000250|UniProtKB:Q568T5,ECO:0000250|UniProtKB:Q9CXM0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LANCL2_CHODL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LANCL2_CHODL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LANCL2OTUD5, TCF3, TERF2IP, TERF2, APP, MON1B, CDK9, EGFR, APPBP2, MOV10, NXF1, FAM188A, GSTM3, MCM2, NF2, RHOU, AIRE, DOK2, KCNJ5, PVR, GMFG, FEZ1, PCGF2CHODL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LANCL2_CHODL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LANCL2_CHODL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource