FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 19408

FusionGeneSummary for LAMC2_OAS2

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMC2_OAS2
Fusion gene ID: 19408
HgeneTgene
Gene symbol

LAMC2

OAS2

Gene ID

3918

4939

Gene namelaminin subunit gamma 22'-5'-oligoadenylate synthetase 2
SynonymsB2T|BM600|CSF|EBR2|EBR2A|LAMB2T|LAMNB2-
Cytomap

1q25.3

12q24.13

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit gamma-2BM600-100kDaCSF 140 kDa subunitcell-scattering factor 140 kDa subunitepiligrin subunit gammakalinin subunit gammaladsin 140 kDa subunitlaminin B2t chainlaminin, gamma 2large adhesive scatter factor 140 kDa subunitnicein su2'-5'-oligoadenylate synthase 2(2'-5')oligo(A) synthetase 22'-5'-oligoadenylate synthetase 2, 69/71kDa2-5A synthase 2p69 OAS / p71 OAS
Modification date2018052220180523
UniProtAcc

Q13753

P29728

Ensembl transtripts involved in fusion geneENST00000493293, ENST00000264144, 
ENST00000461729, 
ENST00000342315, 
ENST00000392583, ENST00000449768, 
Fusion gene scores* DoF score4 X 4 X 4=642 X 2 X 2=8
# samples 42
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: LAMC2 [Title/Abstract] AND OAS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-46-3766-01ALAMC2chr1

183187623

+OAS2chr12

113416401

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000493293ENST00000342315LAMC2chr1

183187623

+OAS2chr12

113416401

+
5CDS-5UTRENST00000493293ENST00000392583LAMC2chr1

183187623

+OAS2chr12

113416401

+
5CDS-5UTRENST00000493293ENST00000449768LAMC2chr1

183187623

+OAS2chr12

113416401

+
5CDS-5UTRENST00000264144ENST00000342315LAMC2chr1

183187623

+OAS2chr12

113416401

+
5CDS-5UTRENST00000264144ENST00000392583LAMC2chr1

183187623

+OAS2chr12

113416401

+
5CDS-5UTRENST00000264144ENST00000449768LAMC2chr1

183187623

+OAS2chr12

113416401

+
intron-5UTRENST00000461729ENST00000342315LAMC2chr1

183187623

+OAS2chr12

113416401

+
intron-5UTRENST00000461729ENST00000392583LAMC2chr1

183187623

+OAS2chr12

113416401

+
intron-5UTRENST00000461729ENST00000449768LAMC2chr1

183187623

+OAS2chr12

113416401

+

Top

FusionProtFeatures for LAMC2_OAS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMC2

Q13753

OAS2

P29728

Binding to cells via a high affinity receptor, lamininis thought to mediate the attachment, migration and organizationof cells into tissues during embryonic development by interactingwith other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, includingepithelial, endothelial, and fibroblastic cells.{ECO:0000269|PubMed:8265624}. Interferon-induced, dsRNA-activated antiviral enzymewhich plays a critical role in cellular innate antiviral response(PubMed:10464285, PubMed:9880569). Activated by detection ofdouble stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactivemonomeric form of ribonuclease L (RNASEL) leading to itsdimerization and subsequent activation (PubMed:10464285,PubMed:9880569, PubMed:11682059). Activation of RNASEL leads todegradation of cellular as well as viral RNA, resulting in theinhibition of protein synthesis, thus terminating viralreplication (PubMed:10464285, PubMed:9880569). Can mediate theantiviral effect via the classical RNASEL-dependent pathway or analternative antiviral pathway independent of RNASEL(PubMed:21142819). In addition, it may also play a role in othercellular processes such as apoptosis, cell growth, differentiationand gene regulation (PubMed:21142819). May act as a negativeregulator of lactation, stopping lactation in virally infectedmammary gland lobules, thereby preventing transmission of virusesto neonates (By similarity). Non-infected lobules would not beaffected, allowing efficient pup feeding during infection (Bysimilarity). {ECO:0000250|UniProtKB:E9Q9A9,ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:11682059,ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880569,ECO:0000303|PubMed:21142819}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LAMC2_OAS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LAMC2_OAS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LAMC2COL7A1, SLA2, PDIA3, YY1, DTNBP1OAS2APP, CLK3, GIMAP8, PRKG1, ACACA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LAMC2_OAS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for LAMC2_OAS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAMC2C0023890Liver Cirrhosis1CTD_human
HgeneLAMC2C0268374Adult junctional epidermolysis bullosa (disorder)1CTD_human;ORPHANET
TgeneOAS2C0011570Mental Depression1PSYGENET
TgeneOAS2C0011581Depressive disorder1PSYGENET
TgeneOAS2C0021400Influenza1CTD_human
TgeneOAS2C0041696Unipolar Depression1PSYGENET
TgeneOAS2C0338715Drug-induced depressive state1PSYGENET
TgeneOAS2C1269683Major Depressive Disorder1PSYGENET