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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19373

FusionGeneSummary for LAMA5_DAPL1

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMA5_DAPL1
Fusion gene ID: 19373
HgeneTgene
Gene symbol

LAMA5

DAPL1

Gene ID

3911

92196

Gene namelaminin subunit alpha 5death associated protein like 1
Synonyms--
Cytomap

20q13.33

2q24.1

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit alpha-5laminin alpha-5 chainlaminin-10 subunit alphalaminin-11 subunit alphalaminin-15 subunit alphadeath-associated protein-like 1early epithelial differentiation-associated protein
Modification date2018052220180523
UniProtAcc

O15230

A0PJW8

Ensembl transtripts involved in fusion geneENST00000492698, ENST00000252999, 
ENST00000370692, ENST00000370677, 
ENST00000309950, ENST00000409042, 
Fusion gene scores* DoF score10 X 6 X 9=5402 X 2 X 2=8
# samples 122
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: LAMA5 [Title/Abstract] AND DAPL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLAMA5

GO:0016477

cell migration

11821406

HgeneLAMA5

GO:0034446

substrate adhesion-dependent cell spreading

16236823


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A891-01ALAMA5chr20

60926760

-DAPL1chr2

159718918

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000492698ENST00000309950LAMA5chr20

60926760

-DAPL1chr2

159718918

+
intron-intronENST00000492698ENST00000409042LAMA5chr20

60926760

-DAPL1chr2

159718918

+
5CDS-intronENST00000252999ENST00000309950LAMA5chr20

60926760

-DAPL1chr2

159718918

+
5CDS-intronENST00000252999ENST00000409042LAMA5chr20

60926760

-DAPL1chr2

159718918

+
5CDS-intronENST00000370692ENST00000309950LAMA5chr20

60926760

-DAPL1chr2

159718918

+
5CDS-intronENST00000370692ENST00000409042LAMA5chr20

60926760

-DAPL1chr2

159718918

+
5CDS-intronENST00000370677ENST00000309950LAMA5chr20

60926760

-DAPL1chr2

159718918

+
5CDS-intronENST00000370677ENST00000409042LAMA5chr20

60926760

-DAPL1chr2

159718918

+

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FusionProtFeatures for LAMA5_DAPL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMA5

O15230

DAPL1

A0PJW8

Binding to cells via a high affinity receptor, lamininis thought to mediate the attachment, migration and organizationof cells into tissues during embryonic development by interactingwith other extracellular matrix components. May play a role in the early stages of epithelialdifferentiation or in apoptosis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAMA5_DAPL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAMA5_DAPL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LAMA5MEP1A, COL7A1, FBLN2, BCAM, DAG1, CRKL, MYOC, USP4, SMAD2, FBXO6, SUSD4, TMEM25, PTPRK, LAMC1, RNASEH2A, CRP, OS9, SCGB2A2, DEFA1, DKK3, C4orf26, INSL5, UBC, TRIM25DAPL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAMA5_DAPL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAMA5_DAPL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource