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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 19358

FusionGeneSummary for LAMA3_NDUFS8

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMA3_NDUFS8
Fusion gene ID: 19358
HgeneTgene
Gene symbol

LAMA3

NDUFS8

Gene ID

3910

4728

Gene namelaminin subunit alpha 4NADH:ubiquinone oxidoreductase core subunit S8
SynonymsCMD1JJ|LAMA3|LAMA4*-1CI-23k|CI23KD|TYKY
Cytomap

6q21

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit alpha-4laminin alpha 4 chainlaminin, alpha 4NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialNADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)NADH-ubiquinone oxidoreductase 23 kDa subunitcomplex I 23kDa subunitcomplex I-23kD
Modification date2018052220180523
UniProtAcc

Q16787

O00217

Ensembl transtripts involved in fusion geneENST00000313654, ENST00000399516, 
ENST00000269217, ENST00000587184, 
ENST00000588770, 		ENST00000313468, 
ENST00000528492, ENST00000526542, 
Fusion gene scores* DoF score18 X 14 X 9=22682 X 2 X 2=8
# samples 232
** MAII scorelog2(23/2268*10)=-3.30171487399785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: LAMA3 [Title/Abstract] AND NDUFS8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNDUFS8

GO:0006979

response to oxidative stress

12857734


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-8297-01ALAMA3chr18

21364121

+NDUFS8chr11

67800390

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000313654ENST00000313468LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
5CDS-intronENST00000313654ENST00000528492LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
5CDS-intronENST00000313654ENST00000526542LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
In-frameENST00000399516ENST00000313468LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
5CDS-intronENST00000399516ENST00000528492LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
5CDS-intronENST00000399516ENST00000526542LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-3CDSENST00000269217ENST00000313468LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-intronENST00000269217ENST00000528492LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-intronENST00000269217ENST00000526542LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-3CDSENST00000587184ENST00000313468LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-intronENST00000587184ENST00000528492LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-intronENST00000587184ENST00000526542LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-3CDSENST00000588770ENST00000313468LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-intronENST00000588770ENST00000528492LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-intronENST00000588770ENST00000526542LAMA3chr18

21364121

+NDUFS8chr11

67800390

+

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FusionProtFeatures for LAMA3_NDUFS8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMA3

Q16787

NDUFS8

O00217

Core subunit of the mitochondrial membrane respiratorychain NADH dehydrogenase (Complex I) that is believed to belong tothe minimal assembly required for catalysis. Complex I functionsin the transfer of electrons from NADH to the respiratory chain.The immediate electron acceptor for the enzyme is believed to beubiquinone (By similarity). May donate electrons to ubiquinone.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275299_3555343334DomainLaminin EGF-like 1
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275356_4255343334DomainLaminin EGF-like 2
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275426_4695343334DomainLaminin EGF-like 3
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+127543_2985343334DomainLaminin N-terminal
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275491_5355343334DomainLaminin EGF-like 4
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274299_3555343278DomainLaminin EGF-like 1
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274356_4255343278DomainLaminin EGF-like 2
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274426_4695343278DomainLaminin EGF-like 3
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+127443_2985343278DomainLaminin N-terminal
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274491_5355343278DomainLaminin EGF-like 4
TgeneNDUFS8chr18:21364121chr11:67800390ENST00000313468+27102_13136211DomainNote=4Fe-4S ferredoxin-type 1
TgeneNDUFS8chr18:21364121chr11:67800390ENST00000313468+27141_17036211DomainNote=4Fe-4S ferredoxin-type 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751852_19415343334Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751987_21695343334Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12752322_23885343334Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741852_19415343278Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741987_21695343278Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12742322_23885343278Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371852_194101669Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371987_216901669Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1372322_238801669Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751266_13115343334DomainLaminin EGF-like 9
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751312_13555343334DomainLaminin EGF-like 10
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751356_14045343334DomainLaminin EGF-like 11
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751405_14555343334DomainLaminin EGF-like 12
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751476_16535343334DomainLaminin IV type A
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751687_17335343334DomainLaminin EGF-like 13
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751734_17865343334DomainLaminin EGF-like 14
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751787_18215343334DomainLaminin EGF-like 15%3B truncated
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12752390_25915343334DomainLaminin G-like 1
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12752598_27605343334DomainLaminin G-like 2
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12752767_29275343334DomainLaminin G-like 3
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12752986_31505343334DomainLaminin G-like 4
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12753157_33305343334DomainLaminin G-like 5
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275536_5885343334DomainLaminin EGF-like 5
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275590_6305343334DomainLaminin EGF-like 6
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275631_6835343334DomainLaminin EGF-like 7
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275684_7285343334DomainLaminin EGF-like 8
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741266_13115343278DomainLaminin EGF-like 9
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741312_13555343278DomainLaminin EGF-like 10
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741356_14045343278DomainLaminin EGF-like 11
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741405_14555343278DomainLaminin EGF-like 12
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741476_16535343278DomainLaminin IV type A
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741687_17335343278DomainLaminin EGF-like 13
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741734_17865343278DomainLaminin EGF-like 14
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741787_18215343278DomainLaminin EGF-like 15%3B truncated
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12742390_25915343278DomainLaminin G-like 1
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12742598_27605343278DomainLaminin G-like 2
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12742767_29275343278DomainLaminin G-like 3
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12742986_31505343278DomainLaminin G-like 4
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12743157_33305343278DomainLaminin G-like 5
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274536_5885343278DomainLaminin EGF-like 5
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274590_6305343278DomainLaminin EGF-like 6
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274631_6835343278DomainLaminin EGF-like 7
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274684_7285343278DomainLaminin EGF-like 8
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371266_131101669DomainLaminin EGF-like 9
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371312_135501669DomainLaminin EGF-like 10
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371356_140401669DomainLaminin EGF-like 11
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371405_145501669DomainLaminin EGF-like 12
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371476_165301669DomainLaminin IV type A
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371687_173301669DomainLaminin EGF-like 13
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371734_178601669DomainLaminin EGF-like 14
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371787_182101669DomainLaminin EGF-like 15%3B truncated
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1372390_259101669DomainLaminin G-like 1
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1372598_276001669DomainLaminin G-like 2
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1372767_292701669DomainLaminin G-like 3
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1372986_315001669DomainLaminin G-like 4
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137299_35501669DomainLaminin EGF-like 1
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1373157_333001669DomainLaminin G-like 5
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137356_42501669DomainLaminin EGF-like 2
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137426_46901669DomainLaminin EGF-like 3
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+13743_29801669DomainLaminin N-terminal
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137491_53501669DomainLaminin EGF-like 4
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137536_58801669DomainLaminin EGF-like 5
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137590_63001669DomainLaminin EGF-like 6
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137631_68301669DomainLaminin EGF-like 7
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137684_72801669DomainLaminin EGF-like 8
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12752278_22805343334MotifCell attachment site
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12742278_22805343278MotifCell attachment site
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1372278_228001669MotifCell attachment site
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751266_14655343334RegionNote=Domain III B
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751654_18215343334RegionNote=Domain III A
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751822_23895343334RegionNote=Domain II and I
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275298_7285343334RegionNote=Domain V
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275796_12655343334RegionNote=Domain IV 1 (domain IV B)
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741266_14655343278RegionNote=Domain III B
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741654_18215343278RegionNote=Domain III A
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741822_23895343278RegionNote=Domain II and I
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274298_7285343278RegionNote=Domain V
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274796_12655343278RegionNote=Domain IV 1 (domain IV B)
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371266_146501669RegionNote=Domain III B
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371654_182101669RegionNote=Domain III A
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371822_238901669RegionNote=Domain II and I
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137298_72801669RegionNote=Domain V
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137796_126501669RegionNote=Domain IV 1 (domain IV B)


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FusionGeneSequence for LAMA3_NDUFS8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LAMA3_ENST00000313654_chr18_21364121_+_NDUFS8_ENST00000313468_chr11_67800390_+_709aa
MAAAARPRGRALGPVLPPTPLLLLVLRVLPACGATARDPGAAAGLSLHPTYFNLAEAARIWATATCGERGPGEGRPQPELYCKLVGGPTA
PGSGHTIQGQFCDYCNSEDPRKAHPVTNAIDGSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSVDFGST
YSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENGEVVVSLINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLG
HLISKAQRDPTVTRRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHG
HASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGCEQGSGRCHCKPNFH
GDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPICQEYVNMQ
DPEMDMKSVTDRAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEP

>In-frame_LAMA3_ENST00000399516_chr18_21364121_+_NDUFS8_ENST00000313468_chr11_67800390_+_709aa
MAAAARPRGRALGPVLPPTPLLLLVLRVLPACGATARDPGAAAGLSLHPTYFNLAEAARIWATATCGERGPGEGRPQPELYCKLVGGPTA
PGSGHTIQGQFCDYCNSEDPRKAHPVTNAIDGSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSVDFGST
YSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENGEVVVSLINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLG
HLISKAQRDPTVTRRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHG
HASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGCEQGSGRCHCKPNFH
GDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPICQEYVNMQ
DPEMDMKSVTDRAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LAMA3_ENST00000313654_chr18_21364121_+_NDUFS8_ENST00000313468_chr11_67800390_+_2127nt
ATGGCGGCGGCCGCGCGGCCTCGGGGTCGGGCACTGGGGCCAGTACTGCCGCCGACGCCGCTGCTCCTGCTGGTACTGCGGGTGCTGCCA
GCCTGCGGGGCGACCGCTCGGGATCCCGGGGCCGCGGCCGGGCTCAGCCTTCACCCGACTTACTTCAACCTGGCCGAGGCGGCGAGGATT
TGGGCCACCGCCACCTGCGGGGAGAGGGGACCCGGCGAGGGGAGGCCCCAGCCCGAGCTCTACTGCAAGTTGGTCGGGGGCCCCACCGCC
CCAGGCAGCGGCCACACCATCCAGGGCCAGTTCTGTGACTATTGCAATTCTGAAGACCCCAGGAAAGCACATCCTGTCACCAATGCCATC
GATGGATCTGAACGTTGGTGGCAAAGCCCTCCCCTGTCCTCAGGCACACAGTACAACAGAGTCAACCTCACCTTGGATCTGGGGCAGCTC
TTCCATGTGGCCTATATTTTAATCAAATTTGCAAATTCTCCTCGCCCTGATCTTTGGGTCTTGGAAAGATCTGTAGACTTTGGAAGCACC
TACTCACCATGGCAATATTTTGCTCATTCTAAAGTAGACTGTTTAAAAGAATTTGGGCGGGAGGCAAATATGGCTGTCACCCGGGATGAT
GATGTACTTTGTGTTACTGAATATTCCCGTATTGTACCTTTGGAAAATGGTGAGGTTGTGGTGTCCTTGATAAACGGTCGTCCAGGTGCA
AAAAATTTTACTTTCTCTCACACCCTGAGGGAGTTTACCAAGGCAACAAACATCCGCTTGCGTTTTCTTAGAACCAATACGCTTCTTGGA
CACCTCATCTCCAAAGCCCAGCGAGATCCAACTGTCACTCGGCGGTATTATTACAGCATAAAGGACATCAGCATTGGTGGGCAGTGTGTT
TGCAATGGCCATGCTGAAGTGTGCAATATAAACAATCCTGAAAAACTGTTTCGGTGTGAATGCCAGCACCACACCTGTGGGGAGACGTGT
GATCGCTGCTGCACAGGGTACAATCAGAGGCGCTGGCGGCCCGCCGCTTGGGAGCAGAGCCACGAGTGTGAAGCATGCAACTGCCACGGC
CATGCCAGCAACTGTTACTATGATCCAGATGTTGAGCGGCAGCAGGCAAGCTTGAATACCCAGGGCATCTATGCTGGTGGAGGGGTCTGC
ATTAACTGTCAGCACAACACAGCTGGAGTAAACTGTGAACAGTGTGCTAAGGGCTATTACCGCCCTTATGGGGTTCCAGTGGATGCCCCT
GATGGCTGCATCCCCTGCAGCTGTGACCCTGAGCATGCGGATGGCTGTGAACAGGGTTCAGGCCGCTGTCACTGCAAGCCAAATTTCCAC
GGAGACAACTGTGAGAAGTGTGCAATTGGATACTACAATTTCCCATTTTGCTTGAGAATTCCCATTTTTCCTGTTTCTACACCAAGTTCA
GAAGATCCAGTAGCTGGAGATATAAAAGGGTGTGACTGTAATCTGGAAGGTGTTCTCCCTGAAATATGTGATGCCCACGGACGGTGCCTG
TGCCGCCCTGGGGTTGAGGGCCCTCGATGTGATACCTGCCGCTCTGGTTTCTACTCATTCCCTATTTGCCAAGAGTATGTGAACATGCAG
GATCCCGAGATGGACATGAAGTCAGTGACTGACCGGGCAGCCCGCACCCTGCTGTGGACTGAGCTCTTCCGAGGCCTGGGCATGACCCTG
AGCTACCTGTTCCGGGAACCGGCCACCATCAACTACCCGTTCGAGAAGGGCCCGCTGAGCCCTCGCTTCCGTGGGGAGCATGCGCTGCGC
CGGTACCCATCCGGGGAGGAGCGTTGCATTGCCTGCAAGCTCTGCGAGGCCATCTGCCCCGCCCAGGCCATCACCATCGAGGCTGAGCCA
AGAGCTGATGGCAGCCGCCGGACCACCCGCTATGACATCGACATGACCAAGTGCATCTACTGCGGCTTCTGCCAGGAGGCCTGTCCCGTG
GATGCCATCGTCGAGGGCCCCAACTTTGAGTTCTCCACGGAGACCCATGAGGAGCTGCTGTACAACAAGGAGAAGTTGCTCAACAACGGG

>In-frame_LAMA3_ENST00000399516_chr18_21364121_+_NDUFS8_ENST00000313468_chr11_67800390_+_2127nt
ATGGCGGCGGCCGCGCGGCCTCGGGGTCGGGCACTGGGGCCAGTACTGCCGCCGACGCCGCTGCTCCTGCTGGTACTGCGGGTGCTGCCA
GCCTGCGGGGCGACCGCTCGGGATCCCGGGGCCGCGGCCGGGCTCAGCCTTCACCCGACTTACTTCAACCTGGCCGAGGCGGCGAGGATT
TGGGCCACCGCCACCTGCGGGGAGAGGGGACCCGGCGAGGGGAGGCCCCAGCCCGAGCTCTACTGCAAGTTGGTCGGGGGCCCCACCGCC
CCAGGCAGCGGCCACACCATCCAGGGCCAGTTCTGTGACTATTGCAATTCTGAAGACCCCAGGAAAGCACATCCTGTCACCAATGCCATC
GATGGATCTGAACGTTGGTGGCAAAGCCCTCCCCTGTCCTCAGGCACACAGTACAACAGAGTCAACCTCACCTTGGATCTGGGGCAGCTC
TTCCATGTGGCCTATATTTTAATCAAATTTGCAAATTCTCCTCGCCCTGATCTTTGGGTCTTGGAAAGATCTGTAGACTTTGGAAGCACC
TACTCACCATGGCAATATTTTGCTCATTCTAAAGTAGACTGTTTAAAAGAATTTGGGCGGGAGGCAAATATGGCTGTCACCCGGGATGAT
GATGTACTTTGTGTTACTGAATATTCCCGTATTGTACCTTTGGAAAATGGTGAGGTTGTGGTGTCCTTGATAAACGGTCGTCCAGGTGCA
AAAAATTTTACTTTCTCTCACACCCTGAGGGAGTTTACCAAGGCAACAAACATCCGCTTGCGTTTTCTTAGAACCAATACGCTTCTTGGA
CACCTCATCTCCAAAGCCCAGCGAGATCCAACTGTCACTCGGCGGTATTATTACAGCATAAAGGACATCAGCATTGGTGGGCAGTGTGTT
TGCAATGGCCATGCTGAAGTGTGCAATATAAACAATCCTGAAAAACTGTTTCGGTGTGAATGCCAGCACCACACCTGTGGGGAGACGTGT
GATCGCTGCTGCACAGGGTACAATCAGAGGCGCTGGCGGCCCGCCGCTTGGGAGCAGAGCCACGAGTGTGAAGCATGCAACTGCCACGGC
CATGCCAGCAACTGTTACTATGATCCAGATGTTGAGCGGCAGCAGGCAAGCTTGAATACCCAGGGCATCTATGCTGGTGGAGGGGTCTGC
ATTAACTGTCAGCACAACACAGCTGGAGTAAACTGTGAACAGTGTGCTAAGGGCTATTACCGCCCTTATGGGGTTCCAGTGGATGCCCCT
GATGGCTGCATCCCCTGCAGCTGTGACCCTGAGCATGCGGATGGCTGTGAACAGGGTTCAGGCCGCTGTCACTGCAAGCCAAATTTCCAC
GGAGACAACTGTGAGAAGTGTGCAATTGGATACTACAATTTCCCATTTTGCTTGAGAATTCCCATTTTTCCTGTTTCTACACCAAGTTCA
GAAGATCCAGTAGCTGGAGATATAAAAGGGTGTGACTGTAATCTGGAAGGTGTTCTCCCTGAAATATGTGATGCCCACGGACGGTGCCTG
TGCCGCCCTGGGGTTGAGGGCCCTCGATGTGATACCTGCCGCTCTGGTTTCTACTCATTCCCTATTTGCCAAGAGTATGTGAACATGCAG
GATCCCGAGATGGACATGAAGTCAGTGACTGACCGGGCAGCCCGCACCCTGCTGTGGACTGAGCTCTTCCGAGGCCTGGGCATGACCCTG
AGCTACCTGTTCCGGGAACCGGCCACCATCAACTACCCGTTCGAGAAGGGCCCGCTGAGCCCTCGCTTCCGTGGGGAGCATGCGCTGCGC
CGGTACCCATCCGGGGAGGAGCGTTGCATTGCCTGCAAGCTCTGCGAGGCCATCTGCCCCGCCCAGGCCATCACCATCGAGGCTGAGCCA
AGAGCTGATGGCAGCCGCCGGACCACCCGCTATGACATCGACATGACCAAGTGCATCTACTGCGGCTTCTGCCAGGAGGCCTGTCCCGTG
GATGCCATCGTCGAGGGCCCCAACTTTGAGTTCTCCACGGAGACCCATGAGGAGCTGCTGTACAACAAGGAGAAGTTGCTCAACAACGGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_LAMA3_ENST00000313654_chr18_21364121_+_NDUFS8_ENST00000313468_chr11_67800390_+_2419nt
GAGCGCTGTCAGTTCCTGATCCGGCTGGTGCCCGCTCCAGCCGCGGCAGGTTCCAGAGCTGAGAGGCCACCCCCACGCCGCGGGCTTCCA
GCGCGTGGAGCAAGGGGAGCGGCCCCGGCGCCGCCCATATCCCCGGCTGCGCTAGTCCTGGCGCTGCAGGTCCGGGAGGCGCAGGCGGAG
AGCGGCGGTGCCCCCGAGCCCCTCTGCGGACGGCTCAGGCGGGAGGACCCCGCGCGGCTGGATGGCGGCGGCCGCGCGGCCTCGGGGTCG
GGCACTGGGGCCAGTACTGCCGCCGACGCCGCTGCTCCTGCTGGTACTGCGGGTGCTGCCAGCCTGCGGGGCGACCGCTCGGGATCCCGG
GGCCGCGGCCGGGCTCAGCCTTCACCCGACTTACTTCAACCTGGCCGAGGCGGCGAGGATTTGGGCCACCGCCACCTGCGGGGAGAGGGG
ACCCGGCGAGGGGAGGCCCCAGCCCGAGCTCTACTGCAAGTTGGTCGGGGGCCCCACCGCCCCAGGCAGCGGCCACACCATCCAGGGCCA
GTTCTGTGACTATTGCAATTCTGAAGACCCCAGGAAAGCACATCCTGTCACCAATGCCATCGATGGATCTGAACGTTGGTGGCAAAGCCC
TCCCCTGTCCTCAGGCACACAGTACAACAGAGTCAACCTCACCTTGGATCTGGGGCAGCTCTTCCATGTGGCCTATATTTTAATCAAATT
TGCAAATTCTCCTCGCCCTGATCTTTGGGTCTTGGAAAGATCTGTAGACTTTGGAAGCACCTACTCACCATGGCAATATTTTGCTCATTC
TAAAGTAGACTGTTTAAAAGAATTTGGGCGGGAGGCAAATATGGCTGTCACCCGGGATGATGATGTACTTTGTGTTACTGAATATTCCCG
TATTGTACCTTTGGAAAATGGTGAGGTTGTGGTGTCCTTGATAAACGGTCGTCCAGGTGCAAAAAATTTTACTTTCTCTCACACCCTGAG
GGAGTTTACCAAGGCAACAAACATCCGCTTGCGTTTTCTTAGAACCAATACGCTTCTTGGACACCTCATCTCCAAAGCCCAGCGAGATCC
AACTGTCACTCGGCGGTATTATTACAGCATAAAGGACATCAGCATTGGTGGGCAGTGTGTTTGCAATGGCCATGCTGAAGTGTGCAATAT
AAACAATCCTGAAAAACTGTTTCGGTGTGAATGCCAGCACCACACCTGTGGGGAGACGTGTGATCGCTGCTGCACAGGGTACAATCAGAG
GCGCTGGCGGCCCGCCGCTTGGGAGCAGAGCCACGAGTGTGAAGCATGCAACTGCCACGGCCATGCCAGCAACTGTTACTATGATCCAGA
TGTTGAGCGGCAGCAGGCAAGCTTGAATACCCAGGGCATCTATGCTGGTGGAGGGGTCTGCATTAACTGTCAGCACAACACAGCTGGAGT
AAACTGTGAACAGTGTGCTAAGGGCTATTACCGCCCTTATGGGGTTCCAGTGGATGCCCCTGATGGCTGCATCCCCTGCAGCTGTGACCC
TGAGCATGCGGATGGCTGTGAACAGGGTTCAGGCCGCTGTCACTGCAAGCCAAATTTCCACGGAGACAACTGTGAGAAGTGTGCAATTGG
ATACTACAATTTCCCATTTTGCTTGAGAATTCCCATTTTTCCTGTTTCTACACCAAGTTCAGAAGATCCAGTAGCTGGAGATATAAAAGG
GTGTGACTGTAATCTGGAAGGTGTTCTCCCTGAAATATGTGATGCCCACGGACGGTGCCTGTGCCGCCCTGGGGTTGAGGGCCCTCGATG
TGATACCTGCCGCTCTGGTTTCTACTCATTCCCTATTTGCCAAGAGTATGTGAACATGCAGGATCCCGAGATGGACATGAAGTCAGTGAC
TGACCGGGCAGCCCGCACCCTGCTGTGGACTGAGCTCTTCCGAGGCCTGGGCATGACCCTGAGCTACCTGTTCCGGGAACCGGCCACCAT
CAACTACCCGTTCGAGAAGGGCCCGCTGAGCCCTCGCTTCCGTGGGGAGCATGCGCTGCGCCGGTACCCATCCGGGGAGGAGCGTTGCAT
TGCCTGCAAGCTCTGCGAGGCCATCTGCCCCGCCCAGGCCATCACCATCGAGGCTGAGCCAAGAGCTGATGGCAGCCGCCGGACCACCCG
CTATGACATCGACATGACCAAGTGCATCTACTGCGGCTTCTGCCAGGAGGCCTGTCCCGTGGATGCCATCGTCGAGGGCCCCAACTTTGA
GTTCTCCACGGAGACCCATGAGGAGCTGCTGTACAACAAGGAGAAGTTGCTCAACAACGGGGACAAGTGGGAGGCCGAGATCGCCGCCAA

>In-frame_LAMA3_ENST00000399516_chr18_21364121_+_NDUFS8_ENST00000313468_chr11_67800390_+_2178nt
ATGGCGGCGGCCGCGCGGCCTCGGGGTCGGGCACTGGGGCCAGTACTGCCGCCGACGCCGCTGCTCCTGCTGGTACTGCGGGTGCTGCCA
GCCTGCGGGGCGACCGCTCGGGATCCCGGGGCCGCGGCCGGGCTCAGCCTTCACCCGACTTACTTCAACCTGGCCGAGGCGGCGAGGATT
TGGGCCACCGCCACCTGCGGGGAGAGGGGACCCGGCGAGGGGAGGCCCCAGCCCGAGCTCTACTGCAAGTTGGTCGGGGGCCCCACCGCC
CCAGGCAGCGGCCACACCATCCAGGGCCAGTTCTGTGACTATTGCAATTCTGAAGACCCCAGGAAAGCACATCCTGTCACCAATGCCATC
GATGGATCTGAACGTTGGTGGCAAAGCCCTCCCCTGTCCTCAGGCACACAGTACAACAGAGTCAACCTCACCTTGGATCTGGGGCAGCTC
TTCCATGTGGCCTATATTTTAATCAAATTTGCAAATTCTCCTCGCCCTGATCTTTGGGTCTTGGAAAGATCTGTAGACTTTGGAAGCACC
TACTCACCATGGCAATATTTTGCTCATTCTAAAGTAGACTGTTTAAAAGAATTTGGGCGGGAGGCAAATATGGCTGTCACCCGGGATGAT
GATGTACTTTGTGTTACTGAATATTCCCGTATTGTACCTTTGGAAAATGGTGAGGTTGTGGTGTCCTTGATAAACGGTCGTCCAGGTGCA
AAAAATTTTACTTTCTCTCACACCCTGAGGGAGTTTACCAAGGCAACAAACATCCGCTTGCGTTTTCTTAGAACCAATACGCTTCTTGGA
CACCTCATCTCCAAAGCCCAGCGAGATCCAACTGTCACTCGGCGGTATTATTACAGCATAAAGGACATCAGCATTGGTGGGCAGTGTGTT
TGCAATGGCCATGCTGAAGTGTGCAATATAAACAATCCTGAAAAACTGTTTCGGTGTGAATGCCAGCACCACACCTGTGGGGAGACGTGT
GATCGCTGCTGCACAGGGTACAATCAGAGGCGCTGGCGGCCCGCCGCTTGGGAGCAGAGCCACGAGTGTGAAGCATGCAACTGCCACGGC
CATGCCAGCAACTGTTACTATGATCCAGATGTTGAGCGGCAGCAGGCAAGCTTGAATACCCAGGGCATCTATGCTGGTGGAGGGGTCTGC
ATTAACTGTCAGCACAACACAGCTGGAGTAAACTGTGAACAGTGTGCTAAGGGCTATTACCGCCCTTATGGGGTTCCAGTGGATGCCCCT
GATGGCTGCATCCCCTGCAGCTGTGACCCTGAGCATGCGGATGGCTGTGAACAGGGTTCAGGCCGCTGTCACTGCAAGCCAAATTTCCAC
GGAGACAACTGTGAGAAGTGTGCAATTGGATACTACAATTTCCCATTTTGCTTGAGAATTCCCATTTTTCCTGTTTCTACACCAAGTTCA
GAAGATCCAGTAGCTGGAGATATAAAAGGGTGTGACTGTAATCTGGAAGGTGTTCTCCCTGAAATATGTGATGCCCACGGACGGTGCCTG
TGCCGCCCTGGGGTTGAGGGCCCTCGATGTGATACCTGCCGCTCTGGTTTCTACTCATTCCCTATTTGCCAAGAGTATGTGAACATGCAG
GATCCCGAGATGGACATGAAGTCAGTGACTGACCGGGCAGCCCGCACCCTGCTGTGGACTGAGCTCTTCCGAGGCCTGGGCATGACCCTG
AGCTACCTGTTCCGGGAACCGGCCACCATCAACTACCCGTTCGAGAAGGGCCCGCTGAGCCCTCGCTTCCGTGGGGAGCATGCGCTGCGC
CGGTACCCATCCGGGGAGGAGCGTTGCATTGCCTGCAAGCTCTGCGAGGCCATCTGCCCCGCCCAGGCCATCACCATCGAGGCTGAGCCA
AGAGCTGATGGCAGCCGCCGGACCACCCGCTATGACATCGACATGACCAAGTGCATCTACTGCGGCTTCTGCCAGGAGGCCTGTCCCGTG
GATGCCATCGTCGAGGGCCCCAACTTTGAGTTCTCCACGGAGACCCATGAGGAGCTGCTGTACAACAAGGAGAAGTTGCTCAACAACGGG
GACAAGTGGGAGGCCGAGATCGCCGCCAACATCCAGGCTGACTACTTGTATCGGTGACGCCCCACCGGCCCGCAGCCCCTGCTGCCCAAT


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FusionGenePPI for LAMA3_NDUFS8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LAMA3SDC2, APC, SIRT1, TUBG1, TSHR, TAZ, PTPRK, PLG, PLAT, SPINK4, CD44, DEFA1, SCGB2A2, GML, SCGB1D4, SLAMF1NDUFS8ICT1, GEM, NDUFS3, NDUFS2, NDUFS7, NDUFV1, NDUFV2, NDUFS1, NDUFS6, CYC1, SURF1, SAMM50, DHODH, COX15, OPA1, NDUFAF3, RPLP0, PSEN1, SDHA, ABCC2, MPV17, RHOT2, RAB5B, HSPA9, ECSIT, NDUFA8, AFG3L2, NDUFA12, ATP6V1E1, SLC25A3, VDAC3, PHB2, RAB1A, RAB1B, SDHB, UQCRC2, UQCRQ, TCTN2, TCTN3, CEP128, TMEM17, NDUFS4, NDUFS5, NDUFA9, NDUFA11, TIMMDC1, VAPA, GOLT1B, COQ9, NDUFAF4, NDUFA4, OCIAD1, C15orf48, DUSP8, MTMR12, NDUFB11, NDUFA13, UBC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAMA3_NDUFS8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAMA3_NDUFS8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAMA3C0027339Nail Diseases1CTD_human
HgeneLAMA3C0037299Skin Ulcer1CTD_human;HPO
HgeneLAMA3C0079301Junctional Epidermolysis Bullosa1CTD_human
HgeneLAMA3C1328355Laryngoonychocutaneous syndrome1CTD_human;ORPHANET
TgeneNDUFS8C0023264Leigh Disease1CTD_human;ORPHANET;UNIPROT
TgeneNDUFS8C0029408Degenerative polyarthritis1CTD_human