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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19354

FusionGeneSummary for LAMA3_GNAL

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMA3_GNAL
Fusion gene ID: 19354
HgeneTgene
Gene symbol

LAMA3

GNAL

Gene ID

3910

2774

Gene namelaminin subunit alpha 4G protein subunit alpha L
SynonymsCMD1JJ|LAMA3|LAMA4*-1DYT25
Cytomap

6q21

18p11.21

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit alpha-4laminin alpha 4 chainlaminin, alpha 4guanine nucleotide-binding protein G(olf) subunit alphaadenylate cyclase-stimulating G alpha protein, olfactory typeguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory typeguanine nucleotide binding protein
Modification date2018052220180523
UniProtAcc

Q16787

P38405

Ensembl transtripts involved in fusion geneENST00000313654, ENST00000399516, 
ENST00000269217, ENST00000587184, 
ENST00000588770, 
ENST00000334049, 
ENST00000535121, ENST00000269162, 
ENST00000423027, ENST00000590972, 
ENST00000602628, 
Fusion gene scores* DoF score18 X 14 X 9=22687 X 5 X 4=140
# samples 237
** MAII scorelog2(23/2268*10)=-3.30171487399785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LAMA3 [Title/Abstract] AND GNAL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-44-7670-01ALAMA3chr18

21294036

+GNALchr18

11753627

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000313654ENST00000334049LAMA3chr18

21294036

+GNALchr18

11753627

+
Frame-shiftENST00000313654ENST00000535121LAMA3chr18

21294036

+GNALchr18

11753627

+
Frame-shiftENST00000313654ENST00000269162LAMA3chr18

21294036

+GNALchr18

11753627

+
Frame-shiftENST00000313654ENST00000423027LAMA3chr18

21294036

+GNALchr18

11753627

+
5CDS-3UTRENST00000313654ENST00000590972LAMA3chr18

21294036

+GNALchr18

11753627

+
5CDS-intronENST00000313654ENST00000602628LAMA3chr18

21294036

+GNALchr18

11753627

+
Frame-shiftENST00000399516ENST00000334049LAMA3chr18

21294036

+GNALchr18

11753627

+
Frame-shiftENST00000399516ENST00000535121LAMA3chr18

21294036

+GNALchr18

11753627

+
Frame-shiftENST00000399516ENST00000269162LAMA3chr18

21294036

+GNALchr18

11753627

+
Frame-shiftENST00000399516ENST00000423027LAMA3chr18

21294036

+GNALchr18

11753627

+
5CDS-3UTRENST00000399516ENST00000590972LAMA3chr18

21294036

+GNALchr18

11753627

+
5CDS-intronENST00000399516ENST00000602628LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3CDSENST00000269217ENST00000334049LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3CDSENST00000269217ENST00000535121LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3CDSENST00000269217ENST00000269162LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3CDSENST00000269217ENST00000423027LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3UTRENST00000269217ENST00000590972LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-intronENST00000269217ENST00000602628LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3CDSENST00000587184ENST00000334049LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3CDSENST00000587184ENST00000535121LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3CDSENST00000587184ENST00000269162LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3CDSENST00000587184ENST00000423027LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3UTRENST00000587184ENST00000590972LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-intronENST00000587184ENST00000602628LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3CDSENST00000588770ENST00000334049LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3CDSENST00000588770ENST00000535121LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3CDSENST00000588770ENST00000269162LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3CDSENST00000588770ENST00000423027LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-3UTRENST00000588770ENST00000590972LAMA3chr18

21294036

+GNALchr18

11753627

+
intron-intronENST00000588770ENST00000602628LAMA3chr18

21294036

+GNALchr18

11753627

+

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FusionProtFeatures for LAMA3_GNAL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMA3

Q16787

GNAL

P38405

Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems. G(olf) alpha mediates signal transductionwithin the olfactory neuroepithelium and the basal ganglia. May beinvolved in some aspect of visual transduction, and in mediatingthe effect of one or more hormones/neurotransmitters.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAMA3_GNAL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAMA3_GNAL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LAMA3SDC2, APC, SIRT1, TUBG1, TSHR, TAZ, PTPRK, PLG, PLAT, SPINK4, CD44, DEFA1, SCGB2A2, GML, SCGB1D4, SLAMF1GNALUSP3, BABAM1, SPATA2, GNAS, CHIA, MAGED2, FNDC5, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAMA3_GNAL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAMA3_GNAL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAMA3C0027339Nail Diseases1CTD_human
HgeneLAMA3C0037299Skin Ulcer1CTD_human;HPO
HgeneLAMA3C0079301Junctional Epidermolysis Bullosa1CTD_human
HgeneLAMA3C1328355Laryngoonychocutaneous syndrome1CTD_human;ORPHANET
TgeneGNALC0005586Bipolar Disorder1PSYGENET
TgeneGNALC0013421Dystonia1CTD_human
TgeneGNALC0036341Schizophrenia1PSYGENET
TgeneGNALC0393593Dystonia Disorders1CTD_human
TgeneGNALC3554447DYSTONIA 251ORPHANET;UNIPROT