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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19349

FusionGeneSummary for LAMA3_ANO2

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMA3_ANO2
Fusion gene ID: 19349
HgeneTgene
Gene symbol

LAMA3

ANO2

Gene ID

3910

57101

Gene namelaminin subunit alpha 4anoctamin 2
SynonymsCMD1JJ|LAMA3|LAMA4*-1C12orf3|TMEM16B
Cytomap

6q21

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit alpha-4laminin alpha 4 chainlaminin, alpha 4anoctamin-2anoctamin 2, calcium activated chloride channeltransmembrane protein 16B (eight membrane-spanning domains)
Modification date2018052220180403
UniProtAcc

Q16787

Q9NQ90

Ensembl transtripts involved in fusion geneENST00000313654, ENST00000399516, 
ENST00000269217, ENST00000587184, 
ENST00000588770, 		ENST00000327087, 
ENST00000546188, ENST00000356134, 
ENST00000538154, 
Fusion gene scores* DoF score18 X 14 X 9=22687 X 8 X 6=336
# samples 239
** MAII scorelog2(23/2268*10)=-3.30171487399785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LAMA3 [Title/Abstract] AND ANO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1724-01ALAMA3chr18

21294036

+ANO2chr12

5641280

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000313654ENST00000327087LAMA3chr18

21294036

+ANO2chr12

5641280

-
5CDS-intronENST00000313654ENST00000546188LAMA3chr18

21294036

+ANO2chr12

5641280

-
5CDS-intronENST00000313654ENST00000356134LAMA3chr18

21294036

+ANO2chr12

5641280

-
5CDS-intronENST00000313654ENST00000538154LAMA3chr18

21294036

+ANO2chr12

5641280

-
5CDS-intronENST00000399516ENST00000327087LAMA3chr18

21294036

+ANO2chr12

5641280

-
5CDS-intronENST00000399516ENST00000546188LAMA3chr18

21294036

+ANO2chr12

5641280

-
5CDS-intronENST00000399516ENST00000356134LAMA3chr18

21294036

+ANO2chr12

5641280

-
5CDS-intronENST00000399516ENST00000538154LAMA3chr18

21294036

+ANO2chr12

5641280

-
intron-intronENST00000269217ENST00000327087LAMA3chr18

21294036

+ANO2chr12

5641280

-
intron-intronENST00000269217ENST00000546188LAMA3chr18

21294036

+ANO2chr12

5641280

-
intron-intronENST00000269217ENST00000356134LAMA3chr18

21294036

+ANO2chr12

5641280

-
intron-intronENST00000269217ENST00000538154LAMA3chr18

21294036

+ANO2chr12

5641280

-
intron-intronENST00000587184ENST00000327087LAMA3chr18

21294036

+ANO2chr12

5641280

-
intron-intronENST00000587184ENST00000546188LAMA3chr18

21294036

+ANO2chr12

5641280

-
intron-intronENST00000587184ENST00000356134LAMA3chr18

21294036

+ANO2chr12

5641280

-
intron-intronENST00000587184ENST00000538154LAMA3chr18

21294036

+ANO2chr12

5641280

-
intron-intronENST00000588770ENST00000327087LAMA3chr18

21294036

+ANO2chr12

5641280

-
intron-intronENST00000588770ENST00000546188LAMA3chr18

21294036

+ANO2chr12

5641280

-
intron-intronENST00000588770ENST00000356134LAMA3chr18

21294036

+ANO2chr12

5641280

-
intron-intronENST00000588770ENST00000538154LAMA3chr18

21294036

+ANO2chr12

5641280

-

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FusionProtFeatures for LAMA3_ANO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMA3

Q16787

ANO2

Q9NQ90

Calcium-activated chloride channel (CaCC) which may playa role in olfactory signal transduction. Odorant molecules bind toodor-sensing receptors (OSRs), leading to an increase in calciumentry that activates CaCC current which amplifies thedepolarization of the OSR cells, ANO2 seems to be the underlyingchloride channel involved in this process. May mediate lightperception amplification in retina. {ECO:0000269|PubMed:19474308,ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21890523,ECO:0000269|PubMed:21984732}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAMA3_ANO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAMA3_ANO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LAMA3SDC2, APC, SIRT1, TUBG1, TSHR, TAZ, PTPRK, PLG, PLAT, SPINK4, CD44, DEFA1, SCGB2A2, GML, SCGB1D4, SLAMF1ANO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAMA3_ANO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAMA3_ANO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAMA3C0027339Nail Diseases1CTD_human
HgeneLAMA3C0037299Skin Ulcer1CTD_human;HPO
HgeneLAMA3C0079301Junctional Epidermolysis Bullosa1CTD_human
HgeneLAMA3C1328355Laryngoonychocutaneous syndrome1CTD_human;ORPHANET