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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19331

FusionGeneSummary for LACRT_PINK1

check button Fusion gene summary
Fusion gene informationFusion gene name: LACRT_PINK1
Fusion gene ID: 19331
HgeneTgene
Gene symbol

LACRT

PINK1

Gene ID

90070

65018

Gene namelacritinPTEN induced putative kinase 1
Synonyms-BRPK|PARK6
Cytomap

12q13.2

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionextracellular glycoprotein lacritinserine/threonine-protein kinase PINK1, mitochondrialPTEN-induced putative kinase protein 1protein kinase BRPK
Modification date2018052320180523
UniProtAcc

Q9GZZ8

Q9BXM7

Ensembl transtripts involved in fusion geneENST00000547511, ENST00000257867, 
ENST00000321556, ENST00000492302, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 5 X 2=30
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LACRT [Title/Abstract] AND PINK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLACRT

GO:0008284

positive regulation of cell proliferation

11419941|16982797

HgeneLACRT

GO:0010669

epithelial structure maintenance

25034600

HgeneLACRT

GO:0016239

positive regulation of macroautophagy

23640897

HgeneLACRT

GO:0019722

calcium-mediated signaling

11419941|16923831

HgeneLACRT

GO:0031665

negative regulation of lipopolysaccharide-mediated signaling pathway

26670139

HgeneLACRT

GO:0033173

calcineurin-NFAT signaling cascade

16923831

HgeneLACRT

GO:0034067

protein localization to Golgi apparatus

16923831

HgeneLACRT

GO:0042742

defense response to bacterium

24942736

HgeneLACRT

GO:0043066

negative regulation of apoptotic process

26670139

HgeneLACRT

GO:0050679

positive regulation of epithelial cell proliferation

16923831

HgeneLACRT

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

11419941

HgeneLACRT

GO:0050850

positive regulation of calcium-mediated signaling

25530855

HgeneLACRT

GO:0051047

positive regulation of secretion

11419941

HgeneLACRT

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

16923831

HgeneLACRT

GO:0060054

positive regulation of epithelial cell proliferation involved in wound healing

25530855

HgeneLACRT

GO:0070075

tear secretion

25034600|25481446

HgeneLACRT

GO:0070886

positive regulation of calcineurin-NFAT signaling cascade

16923831

TgenePINK1

GO:0001934

positive regulation of protein phosphorylation

25244949

TgenePINK1

GO:0002082

regulation of oxidative phosphorylation

20871098

TgenePINK1

GO:0006468

protein phosphorylation

14607334|21177249|25527291

TgenePINK1

GO:0018105

peptidyl-serine phosphorylation

17579517|19880420

TgenePINK1

GO:0031396

regulation of protein ubiquitination

19880420

TgenePINK1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

21177249

TgenePINK1

GO:0035556

intracellular signal transduction

14607334

TgenePINK1

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19880420

TgenePINK1

GO:0043254

regulation of protein complex assembly

19880420

TgenePINK1

GO:1903202

negative regulation of oxidative stress-induced cell death

16632486

TgenePINK1

GO:1903214

regulation of protein targeting to mitochondrion

25244949

TgenePINK1

GO:1903384

negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway

21177249

TgenePINK1

GO:1903751

negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

17579517

TgenePINK1

GO:2001243

negative regulation of intrinsic apoptotic signaling pathway

15087508


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CD723935LACRTchr12

55026094

-PINK1chr1

20964531

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000547511ENST00000321556LACRTchr12

55026094

-PINK1chr1

20964531

+
intron-intronENST00000547511ENST00000492302LACRTchr12

55026094

-PINK1chr1

20964531

+
intron-3CDSENST00000257867ENST00000321556LACRTchr12

55026094

-PINK1chr1

20964531

+
intron-intronENST00000257867ENST00000492302LACRTchr12

55026094

-PINK1chr1

20964531

+

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FusionProtFeatures for LACRT_PINK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LACRT

Q9GZZ8

PINK1

Q9BXM7

Modulates secretion by lacrimal acinar cells. Protects against mitochondrial dysfunction duringcellular stress by phosphorylating mitochondrial proteins.Involved in the clearance of damaged mitochondria via selectiveautophagy (mitophagy) by mediating activation and translocation ofPRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105,PubMed:19966284, PubMed:20404107, PubMed:20798600,PubMed:23620051, PubMed:23754282, PubMed:23933751,PubMed:24660806, PubMed:24751536, PubMed:24784582,PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctionaldepolarized mitochondria through the phosphorylation of MFN2(PubMed:23620051). Activates PRKN in 2 steps: (1) by mediatingphosphorylation at 'Ser-65' of PRKN and (2) mediatingphosphorylation of ubiquitin, converting PRKN to its fully-activeform (PubMed:24660806, PubMed:24751536, PubMed:24784582,PubMed:25527291). Required for ubiquinone reduction bymitochondrial complex I by mediating phosphorylation of complex Isubunit NDUFA10 (By similarity). {ECO:0000250|UniProtKB:Q99MQ3,ECO:0000269|PubMed:14607334, ECO:0000269|PubMed:15087508,ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19966284,ECO:0000269|PubMed:20404107, ECO:0000269|PubMed:20798600,ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282,ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806,ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582,ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LACRT_PINK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LACRT_PINK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LACRT_PINK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LACRT_PINK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePINK1C1853833Parkinson Disease 6, Autosomal Recessive Early-Onset17CTD_human;UNIPROT
TgenePINK1C0030567Parkinson Disease5CTD_human
TgenePINK1C0242422Parkinsonian Disorders4CTD_human
TgenePINK1C0036341Schizophrenia3PSYGENET
TgenePINK1C0027746Nerve Degeneration1CTD_human
TgenePINK1C0027819Neuroblastoma1CTD_human
TgenePINK1C0041696Unipolar Depression1PSYGENET
TgenePINK1C1269683Major Depressive Disorder1PSYGENET