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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19304

FusionGeneSummary for KTN1_DRGX

check button Fusion gene summary
Fusion gene informationFusion gene name: KTN1_DRGX
Fusion gene ID: 19304
HgeneTgene
Gene symbol

KTN1

DRGX

Gene ID

3895

644168

Gene namekinectin 1dorsal root ganglia homeobox
SynonymsCG1|KNT|MU-RMS-40.19DRG11|PRRXL1
Cytomap

14q22.3

10q11.23

Type of geneprotein-codingprotein-coding
DescriptionkinectinCG-1 antigenkinesin receptordorsal root ganglia homeobox proteinpaired related homeobox-like 1paired-like homeodomain trancription factor DRG11
Modification date2018052220180403
UniProtAcc

Q86UP2

A6NNA5

Ensembl transtripts involved in fusion geneENST00000395309, ENST00000413890, 
ENST00000438792, ENST00000395314, 
ENST00000395308, ENST00000395311, 
ENST00000416613, ENST00000554507, 
ENST00000555573, 
ENST00000374139, 
ENST00000434016, 
Fusion gene scores* DoF score8 X 9 X 5=3602 X 2 X 2=8
# samples 112
** MAII scorelog2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: KTN1 [Title/Abstract] AND DRGX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A1A7-01AKTN1chr14

56047072

+DRGXchr10

50594904

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000395309ENST00000374139KTN1chr14

56047072

+DRGXchr10

50594904

-
5UTR-3CDSENST00000395309ENST00000434016KTN1chr14

56047072

+DRGXchr10

50594904

-
5UTR-3CDSENST00000413890ENST00000374139KTN1chr14

56047072

+DRGXchr10

50594904

-
5UTR-3CDSENST00000413890ENST00000434016KTN1chr14

56047072

+DRGXchr10

50594904

-
5UTR-3CDSENST00000438792ENST00000374139KTN1chr14

56047072

+DRGXchr10

50594904

-
5UTR-3CDSENST00000438792ENST00000434016KTN1chr14

56047072

+DRGXchr10

50594904

-
5UTR-3CDSENST00000395314ENST00000374139KTN1chr14

56047072

+DRGXchr10

50594904

-
5UTR-3CDSENST00000395314ENST00000434016KTN1chr14

56047072

+DRGXchr10

50594904

-
5UTR-3CDSENST00000395308ENST00000374139KTN1chr14

56047072

+DRGXchr10

50594904

-
5UTR-3CDSENST00000395308ENST00000434016KTN1chr14

56047072

+DRGXchr10

50594904

-
intron-3CDSENST00000395311ENST00000374139KTN1chr14

56047072

+DRGXchr10

50594904

-
intron-3CDSENST00000395311ENST00000434016KTN1chr14

56047072

+DRGXchr10

50594904

-
intron-3CDSENST00000416613ENST00000374139KTN1chr14

56047072

+DRGXchr10

50594904

-
intron-3CDSENST00000416613ENST00000434016KTN1chr14

56047072

+DRGXchr10

50594904

-
intron-3CDSENST00000554507ENST00000374139KTN1chr14

56047072

+DRGXchr10

50594904

-
intron-3CDSENST00000554507ENST00000434016KTN1chr14

56047072

+DRGXchr10

50594904

-
intron-3CDSENST00000555573ENST00000374139KTN1chr14

56047072

+DRGXchr10

50594904

-
intron-3CDSENST00000555573ENST00000434016KTN1chr14

56047072

+DRGXchr10

50594904

-

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FusionProtFeatures for KTN1_DRGX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KTN1

Q86UP2

DRGX

A6NNA5

Receptor for kinesin thus involved in kinesin-drivenvesicle motility. Accumulates in integrin-based adhesion complexes(IAC) upon integrin aggregation by fibronectin. Transcription factor required for the formation ofcorrect projections from nociceptive sensory neurons to the dorsalhorn of the spinal cord and normal perception of pain.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KTN1_DRGX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KTN1_DRGX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KTN1EEF1D, IKBKE, RHOA, RHOG, RAC1, PSMD7, PLEKHA5, ARRB1, HERC2, NEURL4, CDH2, NPM1, CTPS2, EHD1, HEXA, WARS, BNIP3, MEOX2, SGTA, CLEC7A, SYNE4, BMI1, DTNBP1, RTN4, PTGER3, EEF1G, C17orf59, LPAR1, FAM134C, SPC25, NTRK1, TMEM237, TMEM17, TMEM216, PKN2, XRCC3, RAB7A, EMC2, ATP6AP2, GOLT1B, MMGT1, FOXN1, CDH1, CDR2, SPPL2B, YIPF3, NDEL1, CAPN1, SSX3, VTN, IPPK, ADAM32, FAM167A, TRIM25DRGX


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KTN1_DRGX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KTN1_DRGX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKTN1C0023893Liver Cirrhosis, Experimental1CTD_human