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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19286

FusionGeneSummary for KRT86_ITGA6

check button Fusion gene summary
Fusion gene informationFusion gene name: KRT86_ITGA6
Fusion gene ID: 19286
HgeneTgene
Gene symbol

KRT86

ITGA6

Gene ID

3892

3655

Gene namekeratin 86integrin subunit alpha 6
SynonymsHB6|Hb1|K86|KRTHB1|KRTHB6|MNXCD49f|ITGA6B|VLA-6
Cytomap

12q13.13

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionkeratin, type II cuticular Hb6hair keratin K2.11hard keratin, type II, 6keratin 86, type IIkeratin protein HB6keratin, hair, basic, 6 (monilethrix)type II hair keratin Hb6type-II keratin Kb26integrin alpha-6CD49 antigen-like family member Fintegrin alpha6Bintegrin, alpha 6
Modification date2018051920180522
UniProtAcc

O43790

P23229

Ensembl transtripts involved in fusion geneENST00000544024, ENST00000423955, 
ENST00000293525, 
ENST00000409532, 
ENST00000264107, ENST00000343713, 
ENST00000264106, ENST00000375221, 
ENST00000409080, 
Fusion gene scores* DoF score3 X 3 X 1=93 X 3 X 2=18
# samples 33
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KRT86 [Title/Abstract] AND ITGA6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF849223KRT86chr12

52650972

-ITGA6chr2

173370617

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000544024ENST00000409532KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000544024ENST00000264107KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000544024ENST00000343713KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000544024ENST00000264106KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000544024ENST00000375221KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000544024ENST00000409080KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-intronENST00000423955ENST00000409532KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000423955ENST00000264107KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000423955ENST00000343713KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000423955ENST00000264106KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000423955ENST00000375221KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000423955ENST00000409080KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-intronENST00000293525ENST00000409532KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000293525ENST00000264107KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000293525ENST00000343713KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000293525ENST00000264106KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000293525ENST00000375221KRT86chr12

52650972

-ITGA6chr2

173370617

+
intron-3UTRENST00000293525ENST00000409080KRT86chr12

52650972

-ITGA6chr2

173370617

+

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FusionProtFeatures for KRT86_ITGA6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KRT86

O43790

ITGA6

P23229


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KRT86_ITGA6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KRT86_ITGA6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KRT86_ITGA6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KRT86_ITGA6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKRT86C0546966Monilethrix4CTD_human;ORPHANET;UNIPROT
TgeneITGA6C0003873Rheumatoid Arthritis1CTD_human