FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 19284

FusionGeneSummary for KRT7_KRT7

check button Fusion gene summary
Fusion gene informationFusion gene name: KRT7_KRT7
Fusion gene ID: 19284
HgeneTgene
Gene symbol

KRT7

KRT7

Gene ID

3855

3855

Gene namekeratin 7keratin 7
SynonymsCK7|K2C7|K7|SCLCK7|K2C7|K7|SCL
Cytomap

12q13.13

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionkeratin, type II cytoskeletal 7CK-7cytokeratin 7keratin 7, type IIkeratin, 55K type II cytoskeletalkeratin, simple epithelial type I, K7sarcolectintype II mesothelial keratin K7type-II keratin Kb7keratin, type II cytoskeletal 7CK-7cytokeratin 7keratin 7, type IIkeratin, 55K type II cytoskeletalkeratin, simple epithelial type I, K7sarcolectintype II mesothelial keratin K7type-II keratin Kb7
Modification date2018051920180519
UniProtAcc

P08729

P08729

Ensembl transtripts involved in fusion geneENST00000331817, ENST00000552322, 
ENST00000331817, ENST00000552322, 
Fusion gene scores* DoF score2 X 3 X 1=67 X 7 X 2=98
# samples 37
** MAII scorelog2(3/6*10)=2.32192809488736log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KRT7 [Title/Abstract] AND KRT7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF750197KRT7chr12

52629319

+KRT7chr12

52629448

-
ChiTaRS3.1AU122394KRT7chr12

52631351

+KRT7chr12

52627030

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000331817ENST00000331817KRT7chr12

52629319

+KRT7chr12

52629448

-
intron-intronENST00000331817ENST00000552322KRT7chr12

52629319

+KRT7chr12

52629448

-
intron-intronENST00000552322ENST00000331817KRT7chr12

52629319

+KRT7chr12

52629448

-
intron-intronENST00000552322ENST00000552322KRT7chr12

52629319

+KRT7chr12

52629448

-
5CDS-5UTRENST00000331817ENST00000331817KRT7chr12

52631351

+KRT7chr12

52627030

+
5CDS-intronENST00000331817ENST00000552322KRT7chr12

52631351

+KRT7chr12

52627030

+
intron-5UTRENST00000552322ENST00000331817KRT7chr12

52631351

+KRT7chr12

52627030

+
intron-intronENST00000552322ENST00000552322KRT7chr12

52631351

+KRT7chr12

52627030

+

Top

FusionProtFeatures for KRT7_KRT7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KRT7

P08729

KRT7

P08729

Blocks interferon-dependent interphase and stimulatesDNA synthesis in cells. Involved in the translational regulationof the human papillomavirus type 16 E7 mRNA (HPV16 E7).{ECO:0000269|PubMed:10492017, ECO:0000269|PubMed:12072504}. Blocks interferon-dependent interphase and stimulatesDNA synthesis in cells. Involved in the translational regulationof the human papillomavirus type 16 E7 mRNA (HPV16 E7).{ECO:0000269|PubMed:10492017, ECO:0000269|PubMed:12072504}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for KRT7_KRT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for KRT7_KRT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for KRT7_KRT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneKRT7P08729DB01087PrimaquineKeratin, type II cytoskeletal 7small moleculeapproved
TgeneKRT7P08729DB01087PrimaquineKeratin, type II cytoskeletal 7small moleculeapproved

Top

RelatedDiseases for KRT7_KRT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKRT7C0007134Renal Cell Carcinoma2CTD_human
HgeneKRT7C0019189Hepatitis, Chronic1CTD_human
HgeneKRT7C0023892Biliary cirrhosis1CTD_human
HgeneKRT7C0027626Neoplasm Invasiveness1CTD_human
HgeneKRT7C1510502Oxyphilic Adenoma1CTD_human
HgeneKRT7C1876165Copper-Overload Cirrhosis1CTD_human
TgeneKRT7C0007134Renal Cell Carcinoma2CTD_human
TgeneKRT7C0019189Hepatitis, Chronic1CTD_human
TgeneKRT7C0023892Biliary cirrhosis1CTD_human
TgeneKRT7C0027626Neoplasm Invasiveness1CTD_human
TgeneKRT7C1510502Oxyphilic Adenoma1CTD_human
TgeneKRT7C1876165Copper-Overload Cirrhosis1CTD_human