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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19215

FusionGeneSummary for KRI1_GPKOW

check button Fusion gene summary
Fusion gene informationFusion gene name: KRI1_GPKOW
Fusion gene ID: 19215
HgeneTgene
Gene symbol

KRI1

GPKOW

Gene ID

65095

27238

Gene nameKRI1 homologG-patch domain and KOW motifs
Synonyms-GPATC5|GPATCH5|Spp2|T54
Cytomap

19p13.2

Xp11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein KRI1 homologG-patch domain and KOW motifs-containing proteinG patch domain and KOW motifs-containing proteinprotein MOS2 homolog
Modification date2018052320180519
UniProtAcc

Q8N9T8

Q92917

Ensembl transtripts involved in fusion geneENST00000312962, ENST00000361821, 
ENST00000537964, 
ENST00000156109, 
Fusion gene scores* DoF score5 X 5 X 3=752 X 2 X 2=8
# samples 123
** MAII scorelog2(12/75*10)=0.678071905112638
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/8*10)=1.90689059560852
Context

PubMed: KRI1 [Title/Abstract] AND GPKOW [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV322157KRI1chr19

10671119

+GPKOWchrX

48969439

-
ChiTaRS3.1BF376678KRI1chr19

10671119

+GPKOWchrX

48969439

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000312962ENST00000156109KRI1chr19

10671119

+GPKOWchrX

48969439

-
intron-intronENST00000361821ENST00000156109KRI1chr19

10671119

+GPKOWchrX

48969439

-
intron-intronENST00000537964ENST00000156109KRI1chr19

10671119

+GPKOWchrX

48969439

-

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FusionProtFeatures for KRI1_GPKOW


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KRI1

Q8N9T8

GPKOW

Q92917

RNA-binding protein involved in pre-mRNA splicing.{ECO:0000269|PubMed:25296192}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KRI1_GPKOW


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KRI1_GPKOW


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KRI1_GPKOW


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KRI1_GPKOW


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource