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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19202

FusionGeneSummary for KRAS_RERGL

check button Fusion gene summary
Fusion gene informationFusion gene name: KRAS_RERGL
Fusion gene ID: 19202
HgeneTgene
Gene symbol

KRAS

RERGL

Gene ID

3845

79785

Gene nameKRAS proto-oncogene, GTPaseRERG like
SynonymsC-K-RAS|CFC2|K-RAS2A|K-RAS2B|K-RAS4A|K-RAS4B|K-Ras|KI-RAS|KRAS1|KRAS2|NS|NS3|RALD|RASK2|c-Ki-ras2-
Cytomap

12p12.1

12p12.3

Type of geneprotein-codingprotein-coding
DescriptionGTPase KRasK-Ras 2K-ras p21 proteinKirsten rat sarcoma viral oncogene homologKirsten rat sarcoma viral proto-oncogenePR310 c-K-ras oncogenec-Ki-rasc-Kirsten-ras proteincellular c-Ki-ras2 proto-oncogenecellular transforming proto-oncogeneoncogeneras-related and estrogen-regulated growth inhibitor-like proteinRERG/RAS-like
Modification date2018052720180329
UniProtAcc

P01116

Q9H628

Ensembl transtripts involved in fusion geneENST00000311936, ENST00000557334, 
ENST00000256078, ENST00000556131, 
ENST00000541632, ENST00000229002, 
ENST00000538724, ENST00000536890, 
Fusion gene scores* DoF score4 X 2 X 4=325 X 2 X 3=30
# samples 44
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/30*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KRAS [Title/Abstract] AND RERGL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A1AZ-01AKRASchr12

25398208

-RERGLchr12

18241890

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000311936ENST00000541632KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000311936ENST00000229002KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000311936ENST00000538724KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000311936ENST00000536890KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000557334ENST00000541632KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000557334ENST00000229002KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000557334ENST00000538724KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000557334ENST00000536890KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000256078ENST00000541632KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000256078ENST00000229002KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000256078ENST00000538724KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000256078ENST00000536890KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000556131ENST00000541632KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000556131ENST00000229002KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000556131ENST00000538724KRASchr12

25398208

-RERGLchr12

18241890

-
5CDS-5UTRENST00000556131ENST00000536890KRASchr12

25398208

-RERGLchr12

18241890

-

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FusionProtFeatures for KRAS_RERGL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KRAS

P01116

RERGL

Q9H628

Ras proteins bind GDP/GTP and possess intrinsic GTPaseactivity. Plays an important role in the regulation of cellproliferation (PubMed:23698361, PubMed:22711838). Plays a role inpromoting oncogenic events by inducing transcriptional silencingof tumor suppressor genes (TSGs) in colorectal cancer (CRC) cellsin a ZNF304-dependent manner (PubMed:24623306).{ECO:0000269|PubMed:22711838, ECO:0000269|PubMed:23698361,ECO:0000269|PubMed:24623306, ECO:0000305}. Binds GDP/GTP and may possess intrinsic GTPase activity.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KRAS_RERGL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KRAS_RERGL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KRASRAP1GDS1, HNRNPC, RASSF2, SHOC2, PIK3CA, RALGDS, RAF1, RASSF5, EPB42, PIK3CG, RASGRF2, DNAJA3, PDE4DIP, CCT7, EEF1A1, IGSF21, CALM1, ELAVL1, APP, PHB, EGLN1, LPAR1, RGL2, ADH6, PIK3R2, DDX47, DDX50, MAPK1, BTRC, BCL2, TRAF6, ARAF, MDFI, PSMA3, RBPMS, ZDHHC17, UNK, THOC1, TAF1, MAP2K1, PRPF31, JMJD4, KMT2E, MTNR1A, DIRAS3, RPS19, ZNF764, SVIL, RNFT1, KDM5B, CD83, CWC22, MFHAS1, TTC27, NXT2, PNPLA4, SFPQ, SNRPF, NUP98, TBC1D8, LMLN, ANAPC10, C12orf66, HKDC1, NONO, SLC9A8, ADAM10, RILPL2, RPL18A, PRPF3, COCH, SNRPD2, NAB1, NAPA, LTA4H, C16orf72, STK32A, BCAS2, CCDC114, NHEJ1, A2M, ABCB5, ACSM4, ACTR2, ACVRL1, ADAM22, ADAMTSL5, ADCY8, ALKBH3, ALKBH7, ANAPC1, ANAPC4, ANXA5, NAE1, NAA10, ARID1B, ARL4A, ARPC2, ARPC3, ASB16, CSRNP1, BFSP1, RPF2, BRIX1, RPF1, MRGPRG-AS1, FAM160A2, C11orf72, C12orf56, RGCC, SPACA7, URI1, SHCBP1L, TTPAL, MIS18A, LINC01547, EFCAB12, FNDC9, C6, C6orf48, TMEM248, RPP25L, C9orf84, CCDC171, CA12, CACNA2D2, CALR, CARM1, CASC5, CATSPER1, CCDC112, CCDC120, CCIN, CCNA2, CCT2, CDC16, CDC27, CDC73, CDCA8, CDH5, CDKL3, CHN1, CLCN1, CNOT1, COPS2, COPS4, COPS5, COPS8, COX4I2, CREG1, CRNKL1, CRNN, CTNNAL1, CTNS, CTTNBP2, CXCL16, BCORL1, CXorf40A, CYP11B1, DAG1, DCLK2, DCTN4, DDX43, DGCR14, DHRS7C, DHX38, DIDO1, DNM3, DNTTIP1, DYNLL2, EDA2R, EFNB2, EIF3A, EIF3G, EIF3C, EIF4A3, EMID1, ENPP4, ENPP5, EPRS, ERH, EXOSC10, EXOSC4, F2RL3, FAM115C, FANCA, FBL, KDM2A, FBXL20, FBXO36, FBXW7, FCGR1A, FEZ2, EBLN2, FLJ90680, FLRT2, FOXR1, FREM1, FRMPD1, GATA6, GATAD2A, GCM2, GDF10, GLI3, GMPPB, GNL3L, GON4L, GPR56, HCAR1, GRAP2, GRIP2, GSPT1, HCK, HIGD2A, HMGN2, HOXB5, HOXD1, HSD3B2, HSD3B7, HSDL2, HSPA14, HSPA9, HSPD1, HUWE1, IARS, IARS2, IBTK, IKBKAP, IL1RAP, IREB2, ITM2A, JAK1, KDM3B, KARS, KCMF1, KCNH7, KCTD12, KDELC1, KIAA0101, RGP1, KIAA0509, ISY1, TNRC18, KIF2C, KLHL25, KPRP, KRAS, KRT32, LCE5A, C14orf183, LOC255654, LOC283575, LOC284379, LOC285556, LRRC10, LRRC32, LSM5, MATN2, MCPH1, METAP2, MID1, MLF2, KMT2A, GSDMC, MNDA, MOB3A, WDR83, MPDZ, MRPL30, MRPL49, MRPS36P4, MTX2, MVP, MYLIP, NADK, NAGS, NAP1L6, NAA15, NAV3, NBR2, NCAPD2, NCL, NDUFA9, NEK1, NF1, NMNAT1, NOL3, NOP56, NOL8, NOP10, NPM1P13, NQO2, NR5A1, NUP205, NUP93, NXF1, OIP5, OR2H2, OR4K1, OSBPL9, PARP12, PHF7, PHKBP2, PIN1, PINK1, PIP4K2A, PLA2G2A, PLK1, POLA1, POLM, POLR3B, POLR3F, PON2, PPP1R8, PROM1, PSEN1, PSKH2, PSMA5, PSMB5, PSMB6, PSMD12, PTPN1, QARS, RCHY1, RELN, RFX4, RHBDL2, RIMS1, RLF, RNF40, RPA2, RQCD1, RRP9, RRS1, RSBN1, RTN2, SAE1, SDCCAG8, SEC14L3, SERPINB5, SH2D3A, SH3PXD2B, SHFM1, SLC11A2, SLITRK2, SNAP23, SNRPN, SNW1, SNX2, SPAST, SPATA17, SPTBN5, SPTY2D1, STT3A, SUV39H2, SYPL2, SYTL2, TAS2R62P, TBCD, TEAD2, TGIF2, TIMM22, TK2, TMED10, TMEM177, NDC1, VMP1, TOMM20, TPP2, TRIM3, TRIM36, TRIM39, TRIM44, TSPAN15, TSSK1B, TTC21B, TUBGCP4, TWIST1, UBAC2, UBA1, UBE2D1, UBE2I, UBE2M, UBE2R2, UBE3B, UBTF, UQCR10, UHRF2, USP30, USP6, USP9Y, VNN1, VPRBP, WDR36, WDR37, DCAF13, WFDC12, WWC1, XPO1, ZBTB5, ZC3H10, ZC3H13, ZC3H15, ZC3H18, ZC3HAV1L, ZGPAT, ZMAT1, ZNF260, ZNF584, BCAS3, CCL5, IL24, OSGIN1, THRSP, MOCS2, COX3, CYTB, QDPR, TNFSF13, UQCRC1, FRAT1, ZMYND8, LIMA1, PML, ABCD3, RPS29, SORBS3, TXNL4A, GOLIM4, MED4, NUP107, TTC31, COPS7B, FAM83D, C1orf131, LSM11, PTGR2, NCBP2-AS2, C14orf80, FAM129B, EGFR, SHC1, SOS1, GRB2, DUSP22, RIN1, BRAF, RCE1, ICMT, PREX1, ARL6IP5, LYPD4, NDUFA13, RHOARERGL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KRAS_RERGL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KRAS_RERGL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKRASC0024121Lung Neoplasms31CTD_human
HgeneKRASC0699791Stomach Carcinoma9HPO;UNIPROT
HgeneKRASC0007131Non-Small Cell Lung Carcinoma6CTD_human
HgeneKRASC0009375Colonic Neoplasms6CTD_human
HgeneKRASC0030297Pancreatic Neoplasm6CTD_human;HPO
HgeneKRASC0027659Neoplasms, Experimental5CTD_human
HgeneKRASC0152013Adenocarcinoma of lung (disorder)5CTD_human
HgeneKRASC3809005CARDIOFACIOCUTANEOUS SYNDROME 25UNIPROT
HgeneKRASC0001430Adenoma4CTD_human
HgeneKRASC0018923Hemangiosarcoma4CTD_human
HgeneKRASC0028326Noonan Syndrome4CTD_human;ORPHANET
HgeneKRASC0001418Adenocarcinoma3CTD_human
HgeneKRASC0009404Colorectal Neoplasms3CTD_human
HgeneKRASC1860991NOONAN SYNDROME 33CTD_human;UNIPROT
HgeneKRASC0007137Squamous cell carcinoma2CTD_human
HgeneKRASC0023903Liver neoplasms2CTD_human
HgeneKRASC0038356Stomach Neoplasms2CTD_human
HgeneKRASC0206698Cholangiocarcinoma2CTD_human
HgeneKRASC0587248Costello syndrome (disorder)2CTD_human
HgeneKRASC2239176Liver carcinoma2CTD_human
HgeneKRASC0004114Astrocytoma1CTD_human
HgeneKRASC0007528Cecal Neoplasms1CTD_human
HgeneKRASC0007621Neoplastic Cell Transformation1CTD_human
HgeneKRASC0014175Endometriosis1CTD_human
HgeneKRASC0016978gallbladder neoplasm1CTD_human
HgeneKRASC0023897Liver Diseases, Parasitic1CTD_human
HgeneKRASC0023904Liver Neoplasms, Experimental1CTD_human
HgeneKRASC0024299Lymphoma1CTD_human
HgeneKRASC0026640Mouth Neoplasms1CTD_human
HgeneKRASC0027627Neoplasm Metastasis1CTD_human
HgeneKRASC0027819Neuroblastoma1CTD_human
HgeneKRASC0030849Penile Neoplasms1CTD_human
HgeneKRASC0040136Thyroid Neoplasm1CTD_human
HgeneKRASC0042138Uterine Neoplasms1CTD_human
HgeneKRASC0206682Follicular thyroid carcinoma1CTD_human
HgeneKRASC0349639Juvenile Myelomonocytic Leukemia1CTD_human;HPO;ORPHANET
HgeneKRASC0596263Carcinogenesis1CTD_human
HgeneKRASC0887833Carcinoma, Pancreatic Ductal1CTD_human
HgeneKRASC0919267ovarian neoplasm1CTD_human
HgeneKRASC1275081Cardio-facio-cutaneous syndrome1CTD_human;ORPHANET
HgeneKRASC2931822Nasopharyngeal carcinoma1CTD_human
HgeneKRASC3495559Juvenile arthritis1CTD_human
HgeneKRASC3854181Nevus sebaceous1CTD_human;HPO;ORPHANET