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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19187

FusionGeneSummary for KPNA6_RAB11FIP4

check button Fusion gene summary
Fusion gene informationFusion gene name: KPNA6_RAB11FIP4
Fusion gene ID: 19187
HgeneTgene
Gene symbol

KPNA6

RAB11FIP4

Gene ID

23633

84440

Gene namekaryopherin subunit alpha 6RAB11 family interacting protein 4
SynonymsIPOA7|KPNA7FIP4-Rab11|RAB11-FIP4
Cytomap

1p35.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionimportin subunit alpha-7importin alpha 7 subunitimportin-alpha-S2karyopherin alpha 6 (importin alpha 7)rab11 family-interacting protein 4RAB11 family interacting protein 4 (class II)arfophilin-2
Modification date2018052320180523
UniProtAcc

O60684

Q86YS3

Ensembl transtripts involved in fusion geneENST00000373625, ENST00000537234, 
ENST00000469790, ENST00000545542, 
ENST00000325874, ENST00000581280, 
ENST00000394744, 
Fusion gene scores* DoF score8 X 4 X 7=2249 X 6 X 10=540
# samples 1117
** MAII scorelog2(11/224*10)=-1.02599520853294
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(17/540*10)=-1.66742466091313
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KPNA6 [Title/Abstract] AND RAB11FIP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDREADTCGA-AH-6549-01AKPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000373625ENST00000325874KPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+
5CDS-intronENST00000373625ENST00000581280KPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+
5CDS-intronENST00000373625ENST00000394744KPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+
intron-3CDSENST00000537234ENST00000325874KPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+
intron-intronENST00000537234ENST00000581280KPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+
intron-intronENST00000537234ENST00000394744KPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+
intron-3CDSENST00000469790ENST00000325874KPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+
intron-intronENST00000469790ENST00000581280KPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+
intron-intronENST00000469790ENST00000394744KPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+
intron-3CDSENST00000545542ENST00000325874KPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+
intron-intronENST00000545542ENST00000581280KPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+
intron-intronENST00000545542ENST00000394744KPNA6chr1

32573735

+RAB11FIP4chr17

29844669

+

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FusionProtFeatures for KPNA6_RAB11FIP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KPNA6

O60684

RAB11FIP4

Q86YS3

Functions in nuclear protein import as an adapterprotein for nuclear receptor KPNB1. Binds specifically anddirectly to substrates containing either a simple or bipartite NLSmotif. Docking of the importin/substrate complex to the nuclearpore complex (NPC) is mediated by KPNB1 through binding tonucleoporin FxFG repeats and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to importin-beta and the three components separate andimportin-alpha and -beta are re-exported from the nucleus to thecytoplasm where GTP hydrolysis releases Ran from importin. Thedirectionality of nuclear import is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. Acts as a regulator of endocytic traffic byparticipating in membrane delivery. Required for the abcissionstep in cytokinesis, possibly by acting as an 'address tag'delivering recycling endosome membranes to the cleavage furrowduring late cytokinesis. In case of infection by HCMV (humancytomegalovirus), may participate in egress of the virus out ofnucleus; this function is independent of ARF6.{ECO:0000269|PubMed:12470645}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KPNA6_RAB11FIP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KPNA6_RAB11FIP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KPNA6SPOP, RELB, KPNB1, MEPCE, RAC1, CREBBP, KEAP1, CHD4, ELAVL1, SKP2, CUL3, TAF9, ANP32A, ZNF131, CDKN1B, HDAC1, KPNA2, GFPT1, KPNA3, LMNA, PRKAR2A, TTC1, XRN2, NOP2, NUP50, FRG1B, SURF2, UNK, EXOSC4, IPO5, FBL, HMGB1, NOP58, MORF4L1, MORF4L2, NOP56, PRMT1, PSMC2, RAN, RANBP6, RPL11, NTRK1, MUS81, PTTG1, CDK2AP1, NUP153, NCBP2, CHD8, GSG2, NAF1, CHMP4B, CENPU, FOXE1, MCM2, IKBKG, PHB2, METTL16, MDM2, PTPN2, RNMT, MEAF6, SREK1IP1, KBTBD4, CD2BP2, G3BP1, SMARCB1RAB11FIP4RAB11A, RAB11FIP4, RAB11FIP3, RAB11FIP2, RAB11FIP5, TSG101, KIAA0368, GFI1B, ARF6, TNIP2, SPECC1, FBXO28, SELENBP1, S100A3, DUSP14, LRRC15


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KPNA6_RAB11FIP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KPNA6_RAB11FIP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource