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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19170

FusionGeneSummary for KPNA3_FGF2

check button Fusion gene summary
Fusion gene informationFusion gene name: KPNA3_FGF2
Fusion gene ID: 19170
HgeneTgene
Gene symbol

KPNA3

FGF2

Gene ID

3839

2258

Gene namekaryopherin subunit alpha 3fibroblast growth factor 13
SynonymsIPOA4|SRP1|SRP1gamma|SRP4|hSRP1FGF-13|FGF2|FHF-2|FHF2
Cytomap

13q14.2

Xq26.3-q27.1

Type of geneprotein-codingprotein-coding
Descriptionimportin subunit alpha-4SRP1-gammaimportin alpha 4importin alpha Q2importin alpha-3importin subunit alpha-3karyopherin alpha 3 (importin alpha 4)qip2fibroblast growth factor 13fibroblast growth factor homologous factor 2
Modification date2018052320180519
UniProtAcc

O00505

P09038

Ensembl transtripts involved in fusion geneENST00000261667, ENST00000264498, 
ENST00000608478, 
Fusion gene scores* DoF score8 X 5 X 7=2802 X 2 X 2=8
# samples 92
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: KPNA3 [Title/Abstract] AND FGF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGF2

GO:0000165

MAPK cascade

12244047


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-E5-A2PC-01AKPNA3chr13

50321085

-FGF2chr4

123797476

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000261667ENST00000264498KPNA3chr13

50321085

-FGF2chr4

123797476

+
Frame-shitENST00000261667ENST00000608478KPNA3chr13

50321085

-FGF2chr4

123797476

+

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FusionProtFeatures for KPNA3_FGF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KPNA3

O00505

FGF2

P09038

Functions in nuclear protein import as an adapterprotein for nuclear receptor KPNB1. Binds specifically anddirectly to substrates containing either a simple or bipartite NLSmotif. Docking of the importin/substrate complex to the nuclearpore complex (NPC) is mediated by KPNB1 through binding tonucleoporin FxFG repeats and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to importin-beta and the three components separate andimportin-alpha and -beta are re-exported from the nucleus to thecytoplasm where GTP hydrolysis releases Ran from importin. Thedirectionality of nuclear import is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. In vitro, mediates the nuclearimport of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoproteinprobably through ARM repeats 7-9.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KPNA3_FGF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KPNA3_FGF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KPNA3HNRNPC, FAM50B, ARRB2, ARRB1, NFKB1, KPNB1, RCC1, USP42, MEPCE, SIRT1, CUL3, COIL, ZNF131, BARD1, TP53BP1, CBX5, NACC1, HDAC1, MYOD1, NFE2L2, EPHA2, ERCC3, GATA6, GTF2H1, MCM4, KPNA6, MCM6, MMS19, HSF1, MVP, FTL, MTA1, DDX21, ZBTB24, TSSC4, NUP50, MAT2B, ZCCHC10, RPRD1A, APOL6, SLC5A11, TEX37, POLDIP3, APEX1, IER2, HSPB1, ACTR1A, CANX, CLGN, COPB1, GNL1, HSP90B1, IPO8, IPO9, KPNA2, NRD1, KPNA4, TMCO1, NTRK1, KIF22, NCBP1, NUP153, NCBP2, C10orf12, KMT2E, UBXN7, RBBP4, FAM204A, CTDSPL2, PPM1D, MECP2, B2M, LMNA, GTF2IRD1, BRCA1FGF2SDC1, SDC2, SDC4, CSNK2A1, CSNK2A2, CSNK2B, GPC3, RPS19, VTN, FGFBP1, SDC3, FGFR1, GPC4, RPL6, THBS1, CRYAB, PRMT1, TUBG1, TMEFF1, IFI16, COMT, FGFR2, PRKACA, CD44, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KPNA3_FGF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFGF2P09038DB00364SucralfateFibroblast growth factor 2small moleculeapproved
TgeneFGF2P09038DB00686Pentosan PolysulfateFibroblast growth factor 2small moleculeapproved
TgeneFGF2P09038DB00877SirolimusFibroblast growth factor 2small moleculeapproved|investigational
TgeneFGF2P09038DB01109HeparinFibroblast growth factor 2small moleculeapproved|investigational

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RelatedDiseases for KPNA3_FGF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKPNA3C0036341Schizophrenia3PSYGENET
HgeneKPNA3C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneKPNA3C0041696Unipolar Depression1PSYGENET
HgeneKPNA3C1269683Major Depressive Disorder1PSYGENET
TgeneFGF2C0525045Mood Disorders3PSYGENET
TgeneFGF2C0151744Myocardial Ischemia2CTD_human
TgeneFGF2C0008924Cleft Lip1CTD_human
TgeneFGF2C0008925Cleft Palate1CTD_human
TgeneFGF2C0011581Depressive disorder1CTD_human
TgeneFGF2C0014549Tonic-Clonic Epilepsy1CTD_human
TgeneFGF2C0017638Glioma1CTD_human
TgeneFGF2C0017639Gliosis1CTD_human
TgeneFGF2C0018800Cardiomegaly1CTD_human
TgeneFGF2C0019284Diaphragmatic Hernia1CTD_human
TgeneFGF2C0021368Inflammation1CTD_human
TgeneFGF2C0022658Kidney Diseases1CTD_human
TgeneFGF2C0023890Liver Cirrhosis1CTD_human
TgeneFGF2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneFGF2C0025500Mesothelioma1CTD_human
TgeneFGF2C0027726Nephrotic Syndrome1CTD_human
TgeneFGF2C0027746Nerve Degeneration1CTD_human
TgeneFGF2C0029172Oral Submucous Fibrosis1CTD_human
TgeneFGF2C0031030Periapical Periodontitis1CTD_human
TgeneFGF2C0033054Prenatal Exposure Delayed Effects1CTD_human
TgeneFGF2C0033578Prostatic Neoplasms1CTD_human
TgeneFGF2C0034069Pulmonary Fibrosis1CTD_human
TgeneFGF2C0035126Reperfusion Injury1CTD_human
TgeneFGF2C0036341Schizophrenia1PSYGENET
TgeneFGF2C0036572Seizures1CTD_human
TgeneFGF2C0040028Thrombocythemia, Essential1CTD_human
TgeneFGF2C0085109Corneal Neovascularization1CTD_human
TgeneFGF2C0085207Gestational Diabetes1CTD_human
TgeneFGF2C0236736Cocaine-Related Disorders1CTD_human
TgeneFGF2C0751955Brain Infarction1CTD_human