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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19154

FusionGeneSummary for KNOP1_C16orf62

check button Fusion gene summary
Fusion gene informationFusion gene name: KNOP1_C16orf62
Fusion gene ID: 19154
HgeneTgene
Gene symbol

KNOP1

C16orf62

Gene ID

400506

Gene namelysine rich nucleolar protein 1
Synonyms101F10.1|C16orf88|FAM191A|TSG118
Cytomap

16p12.3

Type of geneprotein-coding
Descriptionlysine-rich nucleolar protein 1family with sequence similarity 191, member Aprotein C16orf88testis-specific gene 118 protein
Modification date20180519
UniProtAcc

Q1ED39

Q7Z3J2

Ensembl transtripts involved in fusion geneENST00000219837, ENST00000568230, 
ENST00000438132, ENST00000542263, 
ENST00000417362, ENST00000251143, 
ENST00000543152, ENST00000448695, 
ENST00000544275, ENST00000538853, 
Fusion gene scores* DoF score2 X 2 X 1=410 X 8 X 7=560
# samples 614
** MAII scorelog2(6/4*10)=3.90689059560852log2(14/560*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KNOP1 [Title/Abstract] AND C16orf62 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW002855KNOP1chr16

19725766

+C16orf62chr16

19710410

+
ChiTaRS3.1AW593547KNOP1chr16

19725766

+C16orf62chr16

19710410

+
ChiTaRS3.1BE552059KNOP1chr16

19725766

+C16orf62chr16

19710410

+
ChiTaRS3.1AW594544KNOP1chr16

19725766

+C16orf62chr16

19710410

+
ChiTaRS3.1BF223053KNOP1chr16

19725766

+C16orf62chr16

19710410

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000219837ENST00000438132KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000219837ENST00000542263KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000219837ENST00000417362KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000219837ENST00000251143KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000219837ENST00000543152KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000219837ENST00000448695KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000219837ENST00000544275KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000219837ENST00000538853KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000568230ENST00000438132KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000568230ENST00000542263KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000568230ENST00000417362KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000568230ENST00000251143KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000568230ENST00000543152KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000568230ENST00000448695KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000568230ENST00000544275KNOP1chr16

19725766

+C16orf62chr16

19710410

+
intron-intronENST00000568230ENST00000538853KNOP1chr16

19725766

+C16orf62chr16

19710410

+

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FusionProtFeatures for KNOP1_C16orf62


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KNOP1

Q1ED39

C16orf62

Q7Z3J2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KNOP1_C16orf62


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KNOP1_C16orf62


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KNOP1_C16orf62


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KNOP1_C16orf62


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource