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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1911

FusionGeneSummary for ANO1_ABCC11

check button Fusion gene summary
Fusion gene informationFusion gene name: ANO1_ABCC11
Fusion gene ID: 1911
HgeneTgene
Gene symbol

ANO1

ABCC11

Gene ID

55107

85320

Gene nameanoctamin 1ATP binding cassette subfamily C member 11
SynonymsDOG1|ORAOV2|TAOS2|TMEM16AEWWD|MRP8|WW
Cytomap

11q13.3

16q12.1

Type of geneprotein-codingprotein-coding
Descriptionanoctamin-1Ca2+-activated Cl- channelanoctamin 1, calcium activated chloride channelcalcium activated chloride channeldiscovered on gastrointestinal stromal tumors protein 1oral cancer overexpressed 2transmembrane protein 16A (eight membrane-spanninATP-binding cassette sub-family C member 11ATP-binding cassette protein C11ATP-binding cassette transporter MRP8ATP-binding cassette transporter sub-family C member 11ATP-binding cassette, sub-family C (CFTR/MRP), member 11multi-resistance protein 8
Modification date2018051920180523
UniProtAcc

Q5XXA6

Q96J66

Ensembl transtripts involved in fusion geneENST00000355303, ENST00000398543, 
ENST00000538023, ENST00000316296, 
ENST00000530676, ENST00000531349, 
ENST00000525494, 
ENST00000353782, 
ENST00000356608, ENST00000394747, 
ENST00000394748, ENST00000537808, 
ENST00000565329, 
Fusion gene scores* DoF score15 X 11 X 8=13204 X 2 X 2=16
# samples 154
** MAII scorelog2(15/1320*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANO1 [Title/Abstract] AND ABCC11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANO1

GO:0006812

cation transport

22946059

TgeneABCC11

GO:0015711

organic anion transport

15537867|16359813

TgeneABCC11

GO:0015865

purine nucleotide transport

12764137


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-C8-A138-01AANO1chr11

69972301

+ABCC11chr16

48211024

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000355303ENST00000353782ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000355303ENST00000356608ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000355303ENST00000394747ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000355303ENST00000394748ANO1chr11

69972301

+ABCC11chr16

48211024

-
5CDS-intronENST00000355303ENST00000537808ANO1chr11

69972301

+ABCC11chr16

48211024

-
5CDS-5UTRENST00000355303ENST00000565329ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000398543ENST00000353782ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000398543ENST00000356608ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000398543ENST00000394747ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000398543ENST00000394748ANO1chr11

69972301

+ABCC11chr16

48211024

-
5CDS-intronENST00000398543ENST00000537808ANO1chr11

69972301

+ABCC11chr16

48211024

-
5CDS-5UTRENST00000398543ENST00000565329ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000538023ENST00000353782ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000538023ENST00000356608ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000538023ENST00000394747ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000538023ENST00000394748ANO1chr11

69972301

+ABCC11chr16

48211024

-
5CDS-intronENST00000538023ENST00000537808ANO1chr11

69972301

+ABCC11chr16

48211024

-
5CDS-5UTRENST00000538023ENST00000565329ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000316296ENST00000353782ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000316296ENST00000356608ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000316296ENST00000394747ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000316296ENST00000394748ANO1chr11

69972301

+ABCC11chr16

48211024

-
5CDS-intronENST00000316296ENST00000537808ANO1chr11

69972301

+ABCC11chr16

48211024

-
5CDS-5UTRENST00000316296ENST00000565329ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000530676ENST00000353782ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000530676ENST00000356608ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000530676ENST00000394747ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000530676ENST00000394748ANO1chr11

69972301

+ABCC11chr16

48211024

-
5CDS-intronENST00000530676ENST00000537808ANO1chr11

69972301

+ABCC11chr16

48211024

-
5CDS-5UTRENST00000530676ENST00000565329ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000531349ENST00000353782ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000531349ENST00000356608ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000531349ENST00000394747ANO1chr11

69972301

+ABCC11chr16

48211024

-
Frame-shitENST00000531349ENST00000394748ANO1chr11

69972301

+ABCC11chr16

48211024

-
5CDS-intronENST00000531349ENST00000537808ANO1chr11

69972301

+ABCC11chr16

48211024

-
5CDS-5UTRENST00000531349ENST00000565329ANO1chr11

69972301

+ABCC11chr16

48211024

-
intron-3CDSENST00000525494ENST00000353782ANO1chr11

69972301

+ABCC11chr16

48211024

-
intron-3CDSENST00000525494ENST00000356608ANO1chr11

69972301

+ABCC11chr16

48211024

-
intron-3CDSENST00000525494ENST00000394747ANO1chr11

69972301

+ABCC11chr16

48211024

-
intron-3CDSENST00000525494ENST00000394748ANO1chr11

69972301

+ABCC11chr16

48211024

-
intron-intronENST00000525494ENST00000537808ANO1chr11

69972301

+ABCC11chr16

48211024

-
intron-5UTRENST00000525494ENST00000565329ANO1chr11

69972301

+ABCC11chr16

48211024

-

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FusionProtFeatures for ANO1_ABCC11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANO1

Q5XXA6

ABCC11

Q96J66

Calcium-activated chloride channel (CaCC) which plays arole in transepithelial anion transport and smooth musclecontraction. Required for the normal functioning of theinterstitial cells of Cajal (ICCs) which generate electricalpacemaker activity in gastrointestinal smooth muscles. Acts as amajor contributor to basal and stimulated chloride conductance inairway epithelial cells and plays an important role in trachealcartilage development. {ECO:0000269|PubMed:20056604,ECO:0000269|PubMed:21984732, ECO:0000269|PubMed:22178883,ECO:0000269|PubMed:22946059}. Participates in physiological processes involving bileacids, conjugated steroids and cyclic nucleotides(PubMed:12764137, PubMed:15537867). Enhances the cellularextrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867).Stimulates the ATP-dependent uptake of a range of physiologicaland synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroidsulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) andestrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholateand taurocholate, and methotrexate (PubMed:15537867,PubMed:25896536). Probably functions to secrete earwax(PubMed:16444273, PubMed:19383836). Required for the secretion ofcomponents contributing to axillary odor formation(PubMed:19710689). {ECO:0000269|PubMed:12764137,ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16444273,ECO:0000269|PubMed:19383836, ECO:0000269|PubMed:19710689,ECO:0000269|PubMed:25896536}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANO1_ABCC11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANO1_ABCC11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANO1EWSR1ABCC11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANO1_ABCC11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANO1_ABCC11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource