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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19074

FusionGeneSummary for KLK3_GSN

check button Fusion gene summary
Fusion gene informationFusion gene name: KLK3_GSN
Fusion gene ID: 19074
HgeneTgene
Gene symbol

KLK3

GSN

Gene ID

354

2934

Gene namekallikrein related peptidase 3gelsolin
SynonymsAPS|KLK2A1|PSA|hK3ADF|AGEL
Cytomap

19q13.33

9q33.2

Type of geneprotein-codingprotein-coding
Descriptionprostate-specific antigenP-30 antigengamma-seminoproteinkallikrein-3semenogelaseseminingelsolinactin-depolymerizing factorbrevin
Modification date2018052320180522
UniProtAcc

P07288

P06396

Ensembl transtripts involved in fusion geneENST00000326003, ENST00000597483, 
ENST00000593997, ENST00000595952, 
ENST00000360617, 
ENST00000373823, 
ENST00000373808, ENST00000436847, 
ENST00000449733, ENST00000412819, 
ENST00000394353, ENST00000341272, 
ENST00000545652, ENST00000373818, 
ENST00000485767, ENST00000373807, 
ENST00000373806, 
Fusion gene scores* DoF score6 X 7 X 1=425 X 8 X 1=40
# samples 79
** MAII scorelog2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/40*10)=1.16992500144231
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KLK3 [Title/Abstract] AND GSN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLK3

GO:0002778

antibacterial peptide production

18714013

TgeneGSN

GO:0030041

actin filament polymerization

3020431

TgeneGSN

GO:0051014

actin filament severing

3020431


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI686170KLK3chr19

51363885

-GSNchr9

124079439

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000326003ENST00000373823KLK3chr19

51363885

-GSNchr9

124079439

-
3UTR-3CDSENST00000326003ENST00000373808KLK3chr19

51363885

-GSNchr9

124079439

-
3UTR-3CDSENST00000326003ENST00000436847KLK3chr19

51363885

-GSNchr9

124079439

-
3UTR-3CDSENST00000326003ENST00000449733KLK3chr19

51363885

-GSNchr9

124079439

-
3UTR-3CDSENST00000326003ENST00000412819KLK3chr19

51363885

-GSNchr9

124079439

-
3UTR-3CDSENST00000326003ENST00000394353KLK3chr19

51363885

-GSNchr9

124079439

-
3UTR-3CDSENST00000326003ENST00000341272KLK3chr19

51363885

-GSNchr9

124079439

-
3UTR-3CDSENST00000326003ENST00000545652KLK3chr19

51363885

-GSNchr9

124079439

-
3UTR-3CDSENST00000326003ENST00000373818KLK3chr19

51363885

-GSNchr9

124079439

-
3UTR-3UTRENST00000326003ENST00000485767KLK3chr19

51363885

-GSNchr9

124079439

-
3UTR-3UTRENST00000326003ENST00000373807KLK3chr19

51363885

-GSNchr9

124079439

-
3UTR-intronENST00000326003ENST00000373806KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000597483ENST00000373823KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000597483ENST00000373808KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000597483ENST00000436847KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000597483ENST00000449733KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000597483ENST00000412819KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000597483ENST00000394353KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000597483ENST00000341272KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000597483ENST00000545652KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000597483ENST00000373818KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3UTRENST00000597483ENST00000485767KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3UTRENST00000597483ENST00000373807KLK3chr19

51363885

-GSNchr9

124079439

-
intron-intronENST00000597483ENST00000373806KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000593997ENST00000373823KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000593997ENST00000373808KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000593997ENST00000436847KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000593997ENST00000449733KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000593997ENST00000412819KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000593997ENST00000394353KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000593997ENST00000341272KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000593997ENST00000545652KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000593997ENST00000373818KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3UTRENST00000593997ENST00000485767KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3UTRENST00000593997ENST00000373807KLK3chr19

51363885

-GSNchr9

124079439

-
intron-intronENST00000593997ENST00000373806KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000595952ENST00000373823KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000595952ENST00000373808KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000595952ENST00000436847KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000595952ENST00000449733KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000595952ENST00000412819KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000595952ENST00000394353KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000595952ENST00000341272KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000595952ENST00000545652KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000595952ENST00000373818KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3UTRENST00000595952ENST00000485767KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3UTRENST00000595952ENST00000373807KLK3chr19

51363885

-GSNchr9

124079439

-
intron-intronENST00000595952ENST00000373806KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000360617ENST00000373823KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000360617ENST00000373808KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000360617ENST00000436847KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000360617ENST00000449733KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000360617ENST00000412819KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000360617ENST00000394353KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000360617ENST00000341272KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000360617ENST00000545652KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3CDSENST00000360617ENST00000373818KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3UTRENST00000360617ENST00000485767KLK3chr19

51363885

-GSNchr9

124079439

-
intron-3UTRENST00000360617ENST00000373807KLK3chr19

51363885

-GSNchr9

124079439

-
intron-intronENST00000360617ENST00000373806KLK3chr19

51363885

-GSNchr9

124079439

-

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FusionProtFeatures for KLK3_GSN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLK3

P07288

GSN

P06396

Hydrolyzes semenogelin-1 thus leading to theliquefaction of the seminal coagulum.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLK3_GSN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLK3_GSN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLK3_GSN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneKLK3P07288DB00834MifepristoneProstate-specific antigensmall moleculeapproved|investigational
HgeneKLK3P07288DB04839Cyproterone acetateProstate-specific antigensmall moleculeapproved|investigational
TgeneGSNP06396DB01593ZincGelsolinsmall moleculeapproved|investigational

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RelatedDiseases for KLK3_GSN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKLK3C0033578Prostatic Neoplasms10CTD_human
HgeneKLK3C0027643Neoplasm Recurrence, Local1CTD_human
HgeneKLK3C1334615Malignant Phyllodes Tumor of Prostate1CTD_human
HgeneKLK3C2937421Prostatic Hyperplasia1CTD_human
TgeneGSNC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneGSNC0025500Mesothelioma1CTD_human
TgeneGSNC0029456Osteoporosis1CTD_human
TgeneGSNC0030524Paratuberculosis1CTD_human
TgeneGSNC0036341Schizophrenia1PSYGENET
TgeneGSNC0043094Weight Gain1CTD_human
TgeneGSNC0948089Acute Coronary Syndrome1CTD_human
TgeneGSNC1622345Meretoja syndrome1CTD_human;ORPHANET;UNIPROT
TgeneGSNC4277682Chemical and Drug Induced Liver Injury1CTD_human