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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19061

FusionGeneSummary for KLK10_ZSCAN29

check button Fusion gene summary
Fusion gene informationFusion gene name: KLK10_ZSCAN29
Fusion gene ID: 19061
HgeneTgene
Gene symbol

KLK10

ZSCAN29

Gene ID

5655

146050

Gene namekallikrein related peptidase 10zinc finger and SCAN domain containing 29
SynonymsNES1|PRSSL1ZNF690|Zfp690
Cytomap

19q13.41

15q15.3

Type of geneprotein-codingprotein-coding
Descriptionkallikrein-10breast normal epithelial cell associated serine proteasekallikrein 10 protein 1kallikrein 10 protein 12kallikrein 10 protein 13kallikrein 10 protein 2kallikrein 10 protein 3kallikrein 10 protein 4kallikrein 10 protein 5kallikrein 10 zinc finger and SCAN domain-containing protein 29KOX31-like zinc finger proteinzinc finger protein 690
Modification date2018052320180519
UniProtAcc

O43240

Q8IWY8

Ensembl transtripts involved in fusion geneENST00000309958, ENST00000391805, 
ENST00000358789, 
ENST00000396976, 
ENST00000396972, ENST00000568898, 
ENST00000562072, ENST00000563508, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 1=4
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: KLK10 [Title/Abstract] AND ZSCAN29 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW999510KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000309958ENST00000396976KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-3UTRENST00000309958ENST00000396972KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-intronENST00000309958ENST00000568898KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-intronENST00000309958ENST00000562072KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-intronENST00000309958ENST00000563508KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-3UTRENST00000391805ENST00000396976KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-3UTRENST00000391805ENST00000396972KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-intronENST00000391805ENST00000568898KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-intronENST00000391805ENST00000562072KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-intronENST00000391805ENST00000563508KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-3UTRENST00000358789ENST00000396976KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-3UTRENST00000358789ENST00000396972KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-intronENST00000358789ENST00000568898KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-intronENST00000358789ENST00000562072KLK10chr19

51517897

-ZSCAN29chr15

43651374

+
intron-intronENST00000358789ENST00000563508KLK10chr19

51517897

-ZSCAN29chr15

43651374

+

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FusionProtFeatures for KLK10_ZSCAN29


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLK10

O43240

ZSCAN29

Q8IWY8

Has a tumor-suppressor role for NES1 in breast andprostate cancer. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLK10_ZSCAN29


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLK10_ZSCAN29


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLK10_ZSCAN29


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KLK10_ZSCAN29


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKLK10C0000786Spontaneous abortion1CTD_human
HgeneKLK10C0038356Stomach Neoplasms1CTD_human
HgeneKLK10C0919267ovarian neoplasm1CTD_human
HgeneKLK10C1458155Mammary Neoplasms1CTD_human