|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 19030 |
FusionGeneSummary for KLHL24_CEP89 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KLHL24_CEP89 | Fusion gene ID: 19030 | Hgene | Tgene | Gene symbol | KLHL24 | CEP89 | Gene ID | 54800 | 84902 |
| Gene name | kelch like family member 24 | centrosomal protein 89 | |
| Synonyms | DRE1|EBSSH|KRIP6 | CCDC123|CEP123 | |
| Cytomap | 3q27.1 | 19q13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kelch-like protein 24kainate receptor interacting protein for GluR6kelch-like 24 | centrosomal protein of 89 kDacentrosomal protein 123centrosomal protein 89kDacoiled-coil domain containing 123coiled-coil domain-containing protein 123, mitochondrial | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6TFL4 | Q96ST8 | |
| Ensembl transtripts involved in fusion gene | ENST00000242810, ENST00000454652, ENST00000476808, ENST00000461813, | ENST00000305768, ENST00000590597, ENST00000591863, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 4 X 3 X 3=36 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KLHL24 [Title/Abstract] AND CEP89 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KLHL24 | GO:0016567 | protein ubiquitination | 27798626 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-21-1071-01A | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000242810 | ENST00000305768 | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
| 5CDS-intron | ENST00000242810 | ENST00000590597 | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
| 5CDS-intron | ENST00000242810 | ENST00000591863 | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
| In-frame | ENST00000454652 | ENST00000305768 | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
| 5CDS-intron | ENST00000454652 | ENST00000590597 | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
| 5CDS-intron | ENST00000454652 | ENST00000591863 | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
| In-frame | ENST00000476808 | ENST00000305768 | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
| 5CDS-intron | ENST00000476808 | ENST00000590597 | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
| 5CDS-intron | ENST00000476808 | ENST00000591863 | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
| intron-3CDS | ENST00000461813 | ENST00000305768 | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
| intron-intron | ENST00000461813 | ENST00000590597 | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
| intron-intron | ENST00000461813 | ENST00000591863 | KLHL24 | chr3 | 183369064 | + | CEP89 | chr19 | 33392318 | - |
Top |
FusionProtFeatures for KLHL24_CEP89 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KLHL24 | CEP89 |
| Necessary to maintain the balance between intermediatefilament stability and degradation, a process that is essentialfor skin integrity (PubMed:27889062). As part of the BCR(KLHL24)E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 andcontrols its levels during keratinocytes differentiation(PubMed:27798626). Specifically reduces kainate receptor-mediatedcurrents in hippocampal neurons, most probably by modulatingchannel properties (By similarity). {ECO:0000250|UniProtKB:Q56A24,ECO:0000269|PubMed:27798626, ECO:0000269|PubMed:27889062}. | Required for ciliogenesis. Also plays a role inmitochondrial metabolism where it may modulate complex IVactivity. {ECO:0000269|PubMed:23348840,ECO:0000269|PubMed:23575228}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000242810 | + | 3 | 8 | 168_270 | 306 | 601 | Domain | Note=BACK |
| Hgene | KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000242810 | + | 3 | 8 | 66_133 | 306 | 601 | Domain | BTB |
| Hgene | KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000454652 | + | 4 | 9 | 168_270 | 306 | 601 | Domain | Note=BACK |
| Hgene | KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000454652 | + | 4 | 9 | 66_133 | 306 | 601 | Domain | BTB |
| Hgene | KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000476808 | + | 1 | 5 | 168_270 | 306 | 538 | Domain | Note=BACK |
| Hgene | KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000476808 | + | 1 | 5 | 66_133 | 306 | 538 | Domain | BTB |
| Tgene | >CEP89 | chr3:183369064 | chr19:33392318 | ENST00000590597 | - | 0 | 9 | 234_333 | -30 | 357 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP89 | chr3:183369064 | chr19:33392318 | ENST00000590597 | - | 0 | 9 | 369_719 | -30 | 357 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000242810 | + | 3 | 8 | 314_363 | 306 | 601 | Repeat | Note=Kelch 1 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000242810 | + | 3 | 8 | 365_407 | 306 | 601 | Repeat | Note=Kelch 2 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000242810 | + | 3 | 8 | 408_454 | 306 | 601 | Repeat | Note=Kelch 3 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000242810 | + | 3 | 8 | 456_502 | 306 | 601 | Repeat | Note=Kelch 4 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000242810 | + | 3 | 8 | 504_544 | 306 | 601 | Repeat | Note=Kelch 5 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000242810 | + | 3 | 8 | 546_592 | 306 | 601 | Repeat | Note=Kelch 6 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000454652 | + | 4 | 9 | 314_363 | 306 | 601 | Repeat | Note=Kelch 1 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000454652 | + | 4 | 9 | 365_407 | 306 | 601 | Repeat | Note=Kelch 2 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000454652 | + | 4 | 9 | 408_454 | 306 | 601 | Repeat | Note=Kelch 3 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000454652 | + | 4 | 9 | 456_502 | 306 | 601 | Repeat | Note=Kelch 4 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000454652 | + | 4 | 9 | 504_544 | 306 | 601 | Repeat | Note=Kelch 5 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000454652 | + | 4 | 9 | 546_592 | 306 | 601 | Repeat | Note=Kelch 6 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000476808 | + | 1 | 5 | 314_363 | 306 | 538 | Repeat | Note=Kelch 1 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000476808 | + | 1 | 5 | 365_407 | 306 | 538 | Repeat | Note=Kelch 2 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000476808 | + | 1 | 5 | 408_454 | 306 | 538 | Repeat | Note=Kelch 3 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000476808 | + | 1 | 5 | 456_502 | 306 | 538 | Repeat | Note=Kelch 4 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000476808 | + | 1 | 5 | 504_544 | 306 | 538 | Repeat | Note=Kelch 5 |
| Hgene | >KLHL24 | chr3:183369064 | chr19:33392318 | ENST00000476808 | + | 1 | 5 | 546_592 | 306 | 538 | Repeat | Note=Kelch 6 |
| Tgene | CEP89 | chr3:183369064 | chr19:33392318 | ENST00000305768 | - | 13 | 19 | 234_333 | 521 | 784 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CEP89 | chr3:183369064 | chr19:33392318 | ENST00000305768 | - | 13 | 19 | 369_719 | 521 | 784 | Coiled coil | Ontology_term=ECO:0000255 |
Top |
FusionGeneSequence for KLHL24_CEP89 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KLHL24_ENST00000242810_chr3_183369064_+_CEP89_ENST00000305768_chr19_33392318_-_569aa MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSY FRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE VDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQK INRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKL GDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLTRTGVQDNPRALVAP >In-frame_KLHL24_ENST00000454652_chr3_183369064_+_CEP89_ENST00000305768_chr19_33392318_-_569aa MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSY FRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE VDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQK INRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKL GDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLTRTGVQDNPRALVAP >In-frame_KLHL24_ENST00000476808_chr3_183369064_+_CEP89_ENST00000305768_chr19_33392318_-_569aa MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSY FRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE VDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQK INRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKL GDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLTRTGVQDNPRALVAP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KLHL24_ENST00000242810_chr3_183369064_+_CEP89_ENST00000305768_chr19_33392318_-_1707nt ATGGTACTAATATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAACTAAGCGAAAAGTTTTTGAAATGGAC CCCAAATCTCTGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACATACTCCAGATATTTAATGAATTTCGT GATAGCCGCTTATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAGCTGTGCTCTCAGCCTGTAGCAGCTAC TTCAGAGCTATGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTATTTTAGCTGAAGCTATGGAATGTTTT TTGCAGTATGTTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGACATCAAGCCTCTTTCAGATTAGTGTT CTCCGTGATGCATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCCAGCGCTTTGCTGATACCCATTCACTC AAAACACTCTTCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACGAAGAATTTCTTGAGCTTGACAAAGAT GAACTTATTGATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAGCCGTCATGCGTTGGGTCTATCGTGCC GTTGATCTGAGAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATCCCAACTACTTTGTTCAAACAGTTGAA GTGGACCAATTGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACCACATACTTGGGAATGAAATGATGTCC CCAAGGACTAGGCCACGCAGCCAATTACAGAAGGAAGAAGAGAAAGAAAGGGCTGAGATGGAGGAGTTGATGGAGAAGCTGACAGTCCTG CAAGCGCAGAAGAAGAGCCTGCTGTTAGAGAAGAACAGTTTGACAGAGCAAAACAAAGCACTGGAAGCCGAACTTGAACGAGCACAGAAA ATCAATAGGAAATCTCAAAAGAAAATTGAGGTCCTCAAAAAGCAGGTGGAAAAAGCCATGGGGAACGAAATGTCTGCTCATCAGTACCTG GCAAACCTTGTTGGCCTGGCAGAAAACATAACCCAGGAACGTGACAGTCTTATGTGTTTGGCAAAATGTTTAGAAAGTGAGAAGGATGGA GTGCTTAATAAAGTCATAAAAAGCAACATTCGCCTGGGAAAGTTAGAGGAAAAAGTCAAGGGCTACAAGAAGCAGGCAGCACTGAAGCTG GGGGACATCAGTCACCGTCTGCTGGAGCAGCAGGAGGACTTCGCCGGCAAGACAGCCCAGTACCGGCAGGAGATGCGGCACCTGCACCAG GTGCTGAAGGACAAGCAGGAGGTGCTGGACCAGGCGCTGCAGCAGAACAGAGAAATGGAAGGTGAACTTGAAGTTATTTGGGAATCTACC TTCAGGGAAAACCGAAGAATCCGAGAACTTCTCCAGGACACACTCACGAGGACAGGCGTGCAGGACAACCCCAGAGCTCTGGTTGCCCCC >In-frame_KLHL24_ENST00000454652_chr3_183369064_+_CEP89_ENST00000305768_chr19_33392318_-_1707nt ATGGTACTAATATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAACTAAGCGAAAAGTTTTTGAAATGGAC CCCAAATCTCTGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACATACTCCAGATATTTAATGAATTTCGT GATAGCCGCTTATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAGCTGTGCTCTCAGCCTGTAGCAGCTAC TTCAGAGCTATGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTATTTTAGCTGAAGCTATGGAATGTTTT TTGCAGTATGTTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGACATCAAGCCTCTTTCAGATTAGTGTT CTCCGTGATGCATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCCAGCGCTTTGCTGATACCCATTCACTC AAAACACTCTTCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACGAAGAATTTCTTGAGCTTGACAAAGAT GAACTTATTGATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAGCCGTCATGCGTTGGGTCTATCGTGCC GTTGATCTGAGAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATCCCAACTACTTTGTTCAAACAGTTGAA GTGGACCAATTGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACCACATACTTGGGAATGAAATGATGTCC CCAAGGACTAGGCCACGCAGCCAATTACAGAAGGAAGAAGAGAAAGAAAGGGCTGAGATGGAGGAGTTGATGGAGAAGCTGACAGTCCTG CAAGCGCAGAAGAAGAGCCTGCTGTTAGAGAAGAACAGTTTGACAGAGCAAAACAAAGCACTGGAAGCCGAACTTGAACGAGCACAGAAA ATCAATAGGAAATCTCAAAAGAAAATTGAGGTCCTCAAAAAGCAGGTGGAAAAAGCCATGGGGAACGAAATGTCTGCTCATCAGTACCTG GCAAACCTTGTTGGCCTGGCAGAAAACATAACCCAGGAACGTGACAGTCTTATGTGTTTGGCAAAATGTTTAGAAAGTGAGAAGGATGGA GTGCTTAATAAAGTCATAAAAAGCAACATTCGCCTGGGAAAGTTAGAGGAAAAAGTCAAGGGCTACAAGAAGCAGGCAGCACTGAAGCTG GGGGACATCAGTCACCGTCTGCTGGAGCAGCAGGAGGACTTCGCCGGCAAGACAGCCCAGTACCGGCAGGAGATGCGGCACCTGCACCAG GTGCTGAAGGACAAGCAGGAGGTGCTGGACCAGGCGCTGCAGCAGAACAGAGAAATGGAAGGTGAACTTGAAGTTATTTGGGAATCTACC TTCAGGGAAAACCGAAGAATCCGAGAACTTCTCCAGGACACACTCACGAGGACAGGCGTGCAGGACAACCCCAGAGCTCTGGTTGCCCCC >In-frame_KLHL24_ENST00000476808_chr3_183369064_+_CEP89_ENST00000305768_chr19_33392318_-_1707nt ATGGTACTAATATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAACTAAGCGAAAAGTTTTTGAAATGGAC CCCAAATCTCTGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACATACTCCAGATATTTAATGAATTTCGT GATAGCCGCTTATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAGCTGTGCTCTCAGCCTGTAGCAGCTAC TTCAGAGCTATGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTATTTTAGCTGAAGCTATGGAATGTTTT TTGCAGTATGTTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGACATCAAGCCTCTTTCAGATTAGTGTT CTCCGTGATGCATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCCAGCGCTTTGCTGATACCCATTCACTC AAAACACTCTTCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACGAAGAATTTCTTGAGCTTGACAAAGAT GAACTTATTGATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAGCCGTCATGCGTTGGGTCTATCGTGCC GTTGATCTGAGAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATCCCAACTACTTTGTTCAAACAGTTGAA GTGGACCAATTGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACCACATACTTGGGAATGAAATGATGTCC CCAAGGACTAGGCCACGCAGCCAATTACAGAAGGAAGAAGAGAAAGAAAGGGCTGAGATGGAGGAGTTGATGGAGAAGCTGACAGTCCTG CAAGCGCAGAAGAAGAGCCTGCTGTTAGAGAAGAACAGTTTGACAGAGCAAAACAAAGCACTGGAAGCCGAACTTGAACGAGCACAGAAA ATCAATAGGAAATCTCAAAAGAAAATTGAGGTCCTCAAAAAGCAGGTGGAAAAAGCCATGGGGAACGAAATGTCTGCTCATCAGTACCTG GCAAACCTTGTTGGCCTGGCAGAAAACATAACCCAGGAACGTGACAGTCTTATGTGTTTGGCAAAATGTTTAGAAAGTGAGAAGGATGGA GTGCTTAATAAAGTCATAAAAAGCAACATTCGCCTGGGAAAGTTAGAGGAAAAAGTCAAGGGCTACAAGAAGCAGGCAGCACTGAAGCTG GGGGACATCAGTCACCGTCTGCTGGAGCAGCAGGAGGACTTCGCCGGCAAGACAGCCCAGTACCGGCAGGAGATGCGGCACCTGCACCAG GTGCTGAAGGACAAGCAGGAGGTGCTGGACCAGGCGCTGCAGCAGAACAGAGAAATGGAAGGTGAACTTGAAGTTATTTGGGAATCTACC TTCAGGGAAAACCGAAGAATCCGAGAACTTCTCCAGGACACACTCACGAGGACAGGCGTGCAGGACAACCCCAGAGCTCTGGTTGCCCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KLHL24_ENST00000242810_chr3_183369064_+_CEP89_ENST00000305768_chr19_33392318_-_2223nt GGCCAGGGTTCGCTGACGCTCAGTGTTTTGGCCCGGACGGTCACATGTTTCCTTTGTTGTGAGCTGCGGCAGAGACTGGTGGCTGGAGGA GACGCCGGCGCTGGAGAGTGCGCTGCGCCGCCCGCCGCTGAGGGACCGCGGGGTTAGCCACTGCTGGCTGCTTCCAGTGTTCGCCGAGAG GTACCGGGGGTGACAGCTCCGGGACCGGCCGAAAGGCGAGGAACCGGTGTGGAAATTAAAAGAACACACATATTTTGACTGGGGCTTTGA TCAACCAAATGCTAAAAAGCCACATAAAGAAGATCCCTAATAGTCATTTCTCAACAATTATATAGTCAACTGATGTAACAATGGTACTAA TATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAACTAAGCGAAAAGTTTTTGAAATGGACCCCAAATCTC TGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACATACTCCAGATATTTAATGAATTTCGTGATAGCCGCT TATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAGCTGTGCTCTCAGCCTGTAGCAGCTACTTCAGAGCTA TGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTATTTTAGCTGAAGCTATGGAATGTTTTTTGCAGTATG TTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGACATCAAGCCTCTTTCAGATTAGTGTTCTCCGTGATG CATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCCAGCGCTTTGCTGATACCCATTCACTCAAAACACTCT TCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACGAAGAATTTCTTGAGCTTGACAAAGATGAACTTATTG ATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAGCCGTCATGCGTTGGGTCTATCGTGCCGTTGATCTGA GAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATCCCAACTACTTTGTTCAAACAGTTGAAGTGGACCAAT TGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACCACATACTTGGGAATGAAATGATGTCCCCAAGGACTA GGCCACGCAGCCAATTACAGAAGGAAGAAGAGAAAGAAAGGGCTGAGATGGAGGAGTTGATGGAGAAGCTGACAGTCCTGCAAGCGCAGA AGAAGAGCCTGCTGTTAGAGAAGAACAGTTTGACAGAGCAAAACAAAGCACTGGAAGCCGAACTTGAACGAGCACAGAAAATCAATAGGA AATCTCAAAAGAAAATTGAGGTCCTCAAAAAGCAGGTGGAAAAAGCCATGGGGAACGAAATGTCTGCTCATCAGTACCTGGCAAACCTTG TTGGCCTGGCAGAAAACATAACCCAGGAACGTGACAGTCTTATGTGTTTGGCAAAATGTTTAGAAAGTGAGAAGGATGGAGTGCTTAATA AAGTCATAAAAAGCAACATTCGCCTGGGAAAGTTAGAGGAAAAAGTCAAGGGCTACAAGAAGCAGGCAGCACTGAAGCTGGGGGACATCA GTCACCGTCTGCTGGAGCAGCAGGAGGACTTCGCCGGCAAGACAGCCCAGTACCGGCAGGAGATGCGGCACCTGCACCAGGTGCTGAAGG ACAAGCAGGAGGTGCTGGACCAGGCGCTGCAGCAGAACAGAGAAATGGAAGGTGAACTTGAAGTTATTTGGGAATCTACCTTCAGGGAAA ACCGAAGAATCCGAGAACTTCTCCAGGACACACTCACGAGGACAGGCGTGCAGGACAACCCCAGAGCTCTGGTTGCCCCCAGCCTCAATG GCGTCTCTCAGGCAGACCTGCTGGACGGCTGCGATGTCTGCTCCTATGACCTGAAGTCTCATGCCCCCACCTGCTAGAATCTGCGGGAGC CCGTGGTGTAGCCTCCTCTGGCCTGAAAGGTCTGCCTCACACAGGCCTTCCCTGCAGGGCAGCCCATGGTGGCAGCCGGAGGTGCGTAAG >In-frame_KLHL24_ENST00000454652_chr3_183369064_+_CEP89_ENST00000305768_chr19_33392318_-_2259nt GTTGTGAGCTGCGGCAGAGACTGGTGGCTGGAGGAGACGCCGGCGCTGGAGAGTGCGCTGCGCCGCCCGCCGCTGAGGGACCGCGGGGTT AGCCACTGCTGGCTGCTTCCAGTGTTCGCCGAGAGGTACCGGGGGTGACAGCTCCGGGACCGGCCGAAAGGCGAGGAACCGGAAGCCCGG GGGAGTGCGACCGCCTCAAATCCAGCCTTCTTGTTTGGTGGGACGACCGTCGGTTCTGTCCGGGAGGAATGACGGGGTCAAGGTGTGGAA ATTAAAAGAACACACATATTTTGACTGGGGCTTTGATCAACCAAATGCTAAAAAGCCACATAAAGAAGATCCCTAATAGTCATTTCTCAA CAATTATATAGTCAACTGATGTAACAATGGTACTAATATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAA CTAAGCGAAAAGTTTTTGAAATGGACCCCAAATCTCTGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACA TACTCCAGATATTTAATGAATTTCGTGATAGCCGCTTATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAG CTGTGCTCTCAGCCTGTAGCAGCTACTTCAGAGCTATGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTA TTTTAGCTGAAGCTATGGAATGTTTTTTGCAGTATGTTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGA CATCAAGCCTCTTTCAGATTAGTGTTCTCCGTGATGCATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCC AGCGCTTTGCTGATACCCATTCACTCAAAACACTCTTCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACG AAGAATTTCTTGAGCTTGACAAAGATGAACTTATTGATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAG CCGTCATGCGTTGGGTCTATCGTGCCGTTGATCTGAGAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATC CCAACTACTTTGTTCAAACAGTTGAAGTGGACCAATTGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACC ACATACTTGGGAATGAAATGATGTCCCCAAGGACTAGGCCACGCAGCCAATTACAGAAGGAAGAAGAGAAAGAAAGGGCTGAGATGGAGG AGTTGATGGAGAAGCTGACAGTCCTGCAAGCGCAGAAGAAGAGCCTGCTGTTAGAGAAGAACAGTTTGACAGAGCAAAACAAAGCACTGG AAGCCGAACTTGAACGAGCACAGAAAATCAATAGGAAATCTCAAAAGAAAATTGAGGTCCTCAAAAAGCAGGTGGAAAAAGCCATGGGGA ACGAAATGTCTGCTCATCAGTACCTGGCAAACCTTGTTGGCCTGGCAGAAAACATAACCCAGGAACGTGACAGTCTTATGTGTTTGGCAA AATGTTTAGAAAGTGAGAAGGATGGAGTGCTTAATAAAGTCATAAAAAGCAACATTCGCCTGGGAAAGTTAGAGGAAAAAGTCAAGGGCT ACAAGAAGCAGGCAGCACTGAAGCTGGGGGACATCAGTCACCGTCTGCTGGAGCAGCAGGAGGACTTCGCCGGCAAGACAGCCCAGTACC GGCAGGAGATGCGGCACCTGCACCAGGTGCTGAAGGACAAGCAGGAGGTGCTGGACCAGGCGCTGCAGCAGAACAGAGAAATGGAAGGTG AACTTGAAGTTATTTGGGAATCTACCTTCAGGGAAAACCGAAGAATCCGAGAACTTCTCCAGGACACACTCACGAGGACAGGCGTGCAGG ACAACCCCAGAGCTCTGGTTGCCCCCAGCCTCAATGGCGTCTCTCAGGCAGACCTGCTGGACGGCTGCGATGTCTGCTCCTATGACCTGA AGTCTCATGCCCCCACCTGCTAGAATCTGCGGGAGCCCGTGGTGTAGCCTCCTCTGGCCTGAAAGGTCTGCCTCACACAGGCCTTCCCTG CAGGGCAGCCCATGGTGGCAGCCGGAGGTGCGTAAGCCCACTGAACGCTGCAGGGCAGGGAAGAAATAAATGGTCTCATAGTTTAATCCA >In-frame_KLHL24_ENST00000476808_chr3_183369064_+_CEP89_ENST00000305768_chr19_33392318_-_1873nt ATGGTACTAATATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAACTAAGCGAAAAGTTTTTGAAATGGAC CCCAAATCTCTGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACATACTCCAGATATTTAATGAATTTCGT GATAGCCGCTTATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAGCTGTGCTCTCAGCCTGTAGCAGCTAC TTCAGAGCTATGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTATTTTAGCTGAAGCTATGGAATGTTTT TTGCAGTATGTTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGACATCAAGCCTCTTTCAGATTAGTGTT CTCCGTGATGCATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCCAGCGCTTTGCTGATACCCATTCACTC AAAACACTCTTCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACGAAGAATTTCTTGAGCTTGACAAAGAT GAACTTATTGATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAGCCGTCATGCGTTGGGTCTATCGTGCC GTTGATCTGAGAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATCCCAACTACTTTGTTCAAACAGTTGAA GTGGACCAATTGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACCACATACTTGGGAATGAAATGATGTCC CCAAGGACTAGGCCACGCAGCCAATTACAGAAGGAAGAAGAGAAAGAAAGGGCTGAGATGGAGGAGTTGATGGAGAAGCTGACAGTCCTG CAAGCGCAGAAGAAGAGCCTGCTGTTAGAGAAGAACAGTTTGACAGAGCAAAACAAAGCACTGGAAGCCGAACTTGAACGAGCACAGAAA ATCAATAGGAAATCTCAAAAGAAAATTGAGGTCCTCAAAAAGCAGGTGGAAAAAGCCATGGGGAACGAAATGTCTGCTCATCAGTACCTG GCAAACCTTGTTGGCCTGGCAGAAAACATAACCCAGGAACGTGACAGTCTTATGTGTTTGGCAAAATGTTTAGAAAGTGAGAAGGATGGA GTGCTTAATAAAGTCATAAAAAGCAACATTCGCCTGGGAAAGTTAGAGGAAAAAGTCAAGGGCTACAAGAAGCAGGCAGCACTGAAGCTG GGGGACATCAGTCACCGTCTGCTGGAGCAGCAGGAGGACTTCGCCGGCAAGACAGCCCAGTACCGGCAGGAGATGCGGCACCTGCACCAG GTGCTGAAGGACAAGCAGGAGGTGCTGGACCAGGCGCTGCAGCAGAACAGAGAAATGGAAGGTGAACTTGAAGTTATTTGGGAATCTACC TTCAGGGAAAACCGAAGAATCCGAGAACTTCTCCAGGACACACTCACGAGGACAGGCGTGCAGGACAACCCCAGAGCTCTGGTTGCCCCC AGCCTCAATGGCGTCTCTCAGGCAGACCTGCTGGACGGCTGCGATGTCTGCTCCTATGACCTGAAGTCTCATGCCCCCACCTGCTAGAAT CTGCGGGAGCCCGTGGTGTAGCCTCCTCTGGCCTGAAAGGTCTGCCTCACACAGGCCTTCCCTGCAGGGCAGCCCATGGTGGCAGCCGGA |
Top |
FusionGenePPI for KLHL24_CEP89 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KLHL24 | COPS5, COPS6, ELAVL1, CUL3, PICK1, TIRAP, PDIA6, PCMT1, FAM219A, RGS3, KLHL28, BOC, PDZK1, PPP1R21, UBE2M, RBP4, TGIF2LY | CEP89 | LATS2, PICK1, PCM1, CEP162, CEP128, ABLIM1, ANKRD26, ANXA1, ATG2B, CEP131, C3orf14, CC2D1A, CCDC138, CCDC14, CCDC66, CCDC77, CCDC85C, CEP170, CEP192, CEP55, CRK, CSPP1, DHX35, DLG5, FGFR1OP, FLII, GPATCH1, HAUS2, HAUS3, HAUS4, HAUS5, HAUS6, HAUS7, HAUS8, KIAA0753, KIF7, LUZP1, MB21D2, MED4, MPHOSPH9, NCS1, NME7, NMT1, OFD1, PIBF1, PLEKHG1, RNF219, SAMD4B, SIRT2, SRBD1, SSX2IP, TCHP, TP53BP2, TXLNG, UNC45A, WDR83, WRAP73, XRN1, YWHAG, YWHAH, ADSL, C2CD3, CEP164, CEP350, CEP72, ERC1, KIAA1671, KIF14, MAP7D3, MARK2, MOB2, MOB4, NAV1, NPHP4, SDCCAG3, SLC25A12, TBC1D2B, TRIM37, TTK, TXLNA, WDR45, TBC1D31, CNTRL, NINL, MYH9, GAR1, CTDSPL, PTPRG, PMF1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for KLHL24_CEP89 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for KLHL24_CEP89 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|