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Fusion gene ID: 19026 |
FusionGeneSummary for KLHL22_UBE2L3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KLHL22_UBE2L3 | Fusion gene ID: 19026 | Hgene | Tgene | Gene symbol | KLHL22 | UBE2L3 | Gene ID | 84861 | 7332 |
| Gene name | kelch like family member 22 | ubiquitin conjugating enzyme E2 L3 | |
| Synonyms | KELCHL | E2-F1|L-UBC|UBCH7|UbcM4 | |
| Cytomap | 22q11.21 | 22q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kelch-like protein 22kelch-like 22 | ubiquitin-conjugating enzyme E2 L3E2 ubiquitin-conjugating enzyme L3ubiquitin carrier protein L3ubiquitin conjugating enzyme E2L 3ubiquitin-conjugating enzyme E2-F1ubiquitin-conjugating enzyme UBCH7ubiquitin-protein ligase L3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q53GT1 | P68036 | |
| Ensembl transtripts involved in fusion gene | ENST00000328879, ENST00000440659, ENST00000470335, | ENST00000458578, ENST00000342192, ENST00000545681, | |
| Fusion gene scores | * DoF score | 9 X 6 X 6=324 | 8 X 4 X 4=128 |
| # samples | 9 | 9 | |
| ** MAII score | log2(9/324*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/128*10)=-0.508146903670325 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KLHL22 [Title/Abstract] AND UBE2L3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KLHL22 | GO:0006513 | protein monoubiquitination | 23455478 |
| Tgene | UBE2L3 | GO:0000209 | protein polyubiquitination | 10888878|14765125 |
| Tgene | UBE2L3 | GO:0006355 | regulation of transcription, DNA-templated | 17003263 |
| Tgene | UBE2L3 | GO:0016567 | protein ubiquitination | 9990509|21532592 |
| Tgene | UBE2L3 | GO:0070979 | protein K11-linked ubiquitination | 20061386 |
| Tgene | UBE2L3 | GO:0071385 | cellular response to glucocorticoid stimulus | 17003263 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1845-01A | KLHL22 | chr22 | 20843272 | - | UBE2L3 | chr22 | 21947150 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000328879 | ENST00000458578 | KLHL22 | chr22 | 20843272 | - | UBE2L3 | chr22 | 21947150 | + |
| In-frame | ENST00000328879 | ENST00000342192 | KLHL22 | chr22 | 20843272 | - | UBE2L3 | chr22 | 21947150 | + |
| 5CDS-intron | ENST00000328879 | ENST00000545681 | KLHL22 | chr22 | 20843272 | - | UBE2L3 | chr22 | 21947150 | + |
| 5UTR-3CDS | ENST00000440659 | ENST00000458578 | KLHL22 | chr22 | 20843272 | - | UBE2L3 | chr22 | 21947150 | + |
| 5UTR-3CDS | ENST00000440659 | ENST00000342192 | KLHL22 | chr22 | 20843272 | - | UBE2L3 | chr22 | 21947150 | + |
| 5UTR-intron | ENST00000440659 | ENST00000545681 | KLHL22 | chr22 | 20843272 | - | UBE2L3 | chr22 | 21947150 | + |
| 5UTR-3CDS | ENST00000470335 | ENST00000458578 | KLHL22 | chr22 | 20843272 | - | UBE2L3 | chr22 | 21947150 | + |
| 5UTR-3CDS | ENST00000470335 | ENST00000342192 | KLHL22 | chr22 | 20843272 | - | UBE2L3 | chr22 | 21947150 | + |
| 5UTR-intron | ENST00000470335 | ENST00000545681 | KLHL22 | chr22 | 20843272 | - | UBE2L3 | chr22 | 21947150 | + |
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FusionProtFeatures for KLHL22_UBE2L3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KLHL22 | UBE2L3 |
| Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3ubiquitin ligase complex required for chromosome alignment andlocalization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitinligase complex mediates monoubiquitination of PLK1, leading toPLK1 dissociation from phosphoreceptor proteins and subsequentremoval from kinetochores, allowing silencing of the spindleassembly checkpoint (SAC) and chromosome segregation.Monoubiquitination of PLK1 does not lead to PLK1 degradation(PubMed:19995937, PubMed:23455478). The BCR(KLHL22) ubiquitinligase complex is also responsible for the amino acid-stimulated'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5.Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an aminoacid-dependent activator within the amino acid-sensing branch ofthe TORC1 pathway, indirectly regulating different cellularprocesses including cell growth and autophagy (PubMed:29769719).{ECO:0000269|PubMed:19995937, ECO:0000269|PubMed:23455478,ECO:0000269|PubMed:29769719}. | Ubiquitin-conjugating enzyme E2 that specifically actswith HECT-type and RBR family E3 ubiquitin-protein ligases. Doesnot function with most RING-containing E3 ubiquitin-proteinligases because it lacks intrinsic E3-independent reactivity withlysine: in contrast, it has activity with the RBR family E3enzymes, such as PRKN and ARIH1, that function like function likeRING-HECT hybrids. Accepts ubiquitin from the E1 complex andcatalyzes its covalent attachment to other proteins. In vitrocatalyzes 'Lys-11'-linked polyubiquitination. Involved in theselective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression throughthe cell cycle. Regulates nuclear hormone receptorstranscriptional activity. May play a role in myelopoiesis.{ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:15367689,ECO:0000269|PubMed:17003263, ECO:0000269|PubMed:18946090,ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:20061386,ECO:0000269|PubMed:21532592}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >KLHL22 | chr22:20843272 | chr22:21947150 | ENST00000328879 | - | 2 | 7 | 50_117 | 75 | 635 | Domain | BTB |
| Hgene | >KLHL22 | chr22:20843272 | chr22:21947150 | ENST00000328879 | - | 2 | 7 | 299_349 | 75 | 635 | Repeat | Note=Kelch 1 |
| Hgene | >KLHL22 | chr22:20843272 | chr22:21947150 | ENST00000328879 | - | 2 | 7 | 350_399 | 75 | 635 | Repeat | Note=Kelch 2 |
| Hgene | >KLHL22 | chr22:20843272 | chr22:21947150 | ENST00000328879 | - | 2 | 7 | 400_446 | 75 | 635 | Repeat | Note=Kelch 3 |
| Hgene | >KLHL22 | chr22:20843272 | chr22:21947150 | ENST00000328879 | - | 2 | 7 | 448_493 | 75 | 635 | Repeat | Note=Kelch 4 |
| Hgene | >KLHL22 | chr22:20843272 | chr22:21947150 | ENST00000328879 | - | 2 | 7 | 494_544 | 75 | 635 | Repeat | Note=Kelch 5 |
| Hgene | >KLHL22 | chr22:20843272 | chr22:21947150 | ENST00000328879 | - | 2 | 7 | 545_593 | 75 | 635 | Repeat | Note=Kelch 6 |
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FusionGeneSequence for KLHL22_UBE2L3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KLHL22_ENST00000328879_chr22_20843272_-_UBE2L3_ENST00000458578_chr22_21947150_+_221aa MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRSLKKSANVGXKTSV TSRLMKLIYXLGKGLLFLTTLHMIREPSESKSTFQQSTHSNHRRSHLKQRSITQTSTKRGRSVCQXLVPKTGSQQPKPTKXSSPSXHWXM >In-frame_KLHL22_ENST00000328879_chr22_20843272_-_UBE2L3_ENST00000342192_chr22_21947150_+_221aa MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRSLKKSANVGXKTSV TSRLMKLIYXLGKGLLFLTTLHMIREPSESKSTFQQSTHSNHRRSHLKQRSITQTSTKRGRSVCQXLVPKTGSQQPKPTKXSSPSXHWXM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KLHL22_ENST00000328879_chr22_20843272_-_UBE2L3_ENST00000458578_chr22_21947150_+_665nt ATGGCAGAGGAGCAGGAGTTCACCCAGCTCTGCAAGTTGCCTGCACAGCCCTCACACCCACACTGCGTGAACAACACCTACCGCAGCGCA CAGCACTCCCAGGCTCTGCTCCGAGGGCTGCTGGCTCTCCGGGACAGCGGAATCCTCTTCGATGTTGTGCTGGTGGTGGAGGGCAGACAC ATCGAGGCCCATCGCATCCTGCTGGCTGCGTCCTGCGATTACTTCAGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTA ACATCCAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCG AAATCAACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGC AGGTCTGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATG ACCCCCAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCTGAAGAGTTTA >In-frame_KLHL22_ENST00000328879_chr22_20843272_-_UBE2L3_ENST00000342192_chr22_21947150_+_665nt ATGGCAGAGGAGCAGGAGTTCACCCAGCTCTGCAAGTTGCCTGCACAGCCCTCACACCCACACTGCGTGAACAACACCTACCGCAGCGCA CAGCACTCCCAGGCTCTGCTCCGAGGGCTGCTGGCTCTCCGGGACAGCGGAATCCTCTTCGATGTTGTGCTGGTGGTGGAGGGCAGACAC ATCGAGGCCCATCGCATCCTGCTGGCTGCGTCCTGCGATTACTTCAGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTA ACATCCAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCG AAATCAACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGC AGGTCTGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATG ACCCCCAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCTGAAGAGTTTA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KLHL22_ENST00000328879_chr22_20843272_-_UBE2L3_ENST00000458578_chr22_21947150_+_1405nt ACGTGACGGCCCAGGCCCCCGCCCCGCCGGCTCCTCTCGCCCAGCCTCCCGCCTCGCGCCTCCCGCCTCCCGCCTCCCGCCTCCCTCCAG CTGCGAGTGCGGCCTCGGCTGGCGGCGGCACCAGGCCACAGTTGTAAGGGATCTTGTGGCTGTCAGGATGGCAGAGGAGCAGGAGTTCAC CCAGCTCTGCAAGTTGCCTGCACAGCCCTCACACCCACACTGCGTGAACAACACCTACCGCAGCGCACAGCACTCCCAGGCTCTGCTCCG AGGGCTGCTGGCTCTCCGGGACAGCGGAATCCTCTTCGATGTTGTGCTGGTGGTGGAGGGCAGACACATCGAGGCCCATCGCATCCTGCT GGCTGCGTCCTGCGATTACTTCAGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTAACATCCAGGTTGATGAAGCTAAT TTATTGACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAGTAC CCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGT GCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCCCAGCCTGAGCACCCGCTT CGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCTGAAGAGTTTACAAAGAAATATGGGGAAAAGCGA CCTGTGGACTAAAATCTGCCACGATTGGTTCCAGCAAGTGTGAGCAGAGACCCCGTGCAGTGCATTCAGACACCCCGCAAAGCAGGACTC TGTGGAAATTGACACGTGCCACCGCCTGGCGTTCGCTTGTGGCAGTTACTAACTTTCTACAGTTTTCTTAATCAAAAGTGGTCTAGGTAA CCTGTAAAGAAAGGATTAAAAATTTAAGATGTTCTAGTTCTGCTCTCTTTGTTTTAAAAATCACTGCTTCAATCTACTTCAAAAGAATGG TGTTTCTTTTCTTGTCCAATTTTATCCAAAATCTTCAAGTTACATTTAACCCATAAGGTTTAAAAAAAAGGAAAAAAAACGGTTGTGGTT CCCTTTCTTCCCTACCCTTGCCACTCCCACTTTCTGGCACCGAGTTTATTTTTCACTTACTTACTTCCCCAGACCCCGGGCTCGCCTCCA CAAAGGAGAAAAGACTGCCCTGGCGGTCCTGGTGGCTTTTCTTAGCATGTGTGGCACTGTTGCCCAGTGTGGGAGTTGGTTTAAATTCTC >In-frame_KLHL22_ENST00000328879_chr22_20843272_-_UBE2L3_ENST00000342192_chr22_21947150_+_3187nt ACGTGACGGCCCAGGCCCCCGCCCCGCCGGCTCCTCTCGCCCAGCCTCCCGCCTCGCGCCTCCCGCCTCCCGCCTCCCGCCTCCCTCCAG CTGCGAGTGCGGCCTCGGCTGGCGGCGGCACCAGGCCACAGTTGTAAGGGATCTTGTGGCTGTCAGGATGGCAGAGGAGCAGGAGTTCAC CCAGCTCTGCAAGTTGCCTGCACAGCCCTCACACCCACACTGCGTGAACAACACCTACCGCAGCGCACAGCACTCCCAGGCTCTGCTCCG AGGGCTGCTGGCTCTCCGGGACAGCGGAATCCTCTTCGATGTTGTGCTGGTGGTGGAGGGCAGACACATCGAGGCCCATCGCATCCTGCT GGCTGCGTCCTGCGATTACTTCAGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTAACATCCAGGTTGATGAAGCTAAT TTATTGACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAGTAC CCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGT GCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCCCAGCCTGAGCACCCGCTT CGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCTGAAGAGTTTACAAAGAAATATGGGGAAAAGCGA CCTGTGGACTAAAATCTGCCACGATTGGTTCCAGCAAGTGTGAGCAGAGACCCCGTGCAGTGCATTCAGACACCCCGCAAAGCAGGACTC TGTGGAAATTGACACGTGCCACCGCCTGGCGTTCGCTTGTGGCAGTTACTAACTTTCTACAGTTTTCTTAATCAAAAGTGGTCTAGGTAA CCTGTAAAGAAAGGATTAAAAATTTAAGATGTTCTAGTTCTGCTCTCTTTGTTTTAAAAATCACTGCTTCAATCTACTTCAAAAGAATGG TGTTTCTTTTCTTGTCCAATTTTATCCAAAATCTTCAAGTTACATTTAACCCATAAGGTTTAAAAAAAAGGAAAAAAAACGGTTGTGGTT CCCTTTCTTCCCTACCCTTGCCACTCCCACTTTCTGGCACCGAGTTTATTTTTCACTTACTTACTTCCCCAGACCCCGGGCTCGCCTCCA CAAAGGAGAAAAGACTGCCCTGGCGGTCCTGGTGGCTTTTCTTAGCATGTGTGGCACTGTTGCCCAGTGTGGGAGTTGGTTTAAATTCTC CTGACTCCAGTTTATAACATCCTTTTAAAAAATTTAAAAACAAACAGCCACACCCCTCCTCCAGTCCTTCTCCTCAGTTCTTGTGTGAAA CTCCAGCTGATGTTACCACAGTAACATCAGTTAATTGGGCAAGCCCTGATGTCAGTGTGTGTAACTGACCTCTGGCCTGGCCTGCACAGA GAAGCCCTATAATCACAGGTCTGTGGTGGCCCCGAAATGGGGGGCCTGCTAGTCAGGAGGATGCTGTGCACACTGTGTGTGATGAATCTC GCCAGAAAGGCTCCTGAGGTCCCAGGTTGGCACTTCTCCCTGCAGCCATTGTAGAAGATCTGCTGGTCCTTGCAGGCAAAGCTACAGCCA GAATGTCCGTTTGAAACTCCTAGCTCATCTGTCACCGAGCTTCATCCGAATGTGCCACGGAGCTTGCTCTCCACTTCCTCCGTGCAGTGG CCCTGCCACAGCCCTCCCTCGGCACACTTTGACCCTTTGTAGGATTGGAATTAGCAGGACTCGGCTATTTAAAGCACCAGTCTGGGGTCG CCTGGGCCCCTGCTGACCCCCTCCTCCAGAGCAGCCAGCCCAGCCCGGGAACAAGACGGACTTCCTCTCCCTTCGGACTCACAGCCTTTG CAGAGTCAAGCTCCACTTGAAGCTCACTCAGTAATATCCTTTCAATGTGTTTTATATTGTTTTGACTGCCTTTTTTTGTAGAAATAAAAA TTGACCTTAGAATTTATCGTCAGATAAACTTGTAAAGATTTGAATATTAATGTCTTTTCAAGGCAAATGGGATTGTCCCCGCACTAGTAG AGAATCCATGTCGCTCTGACACCCCAAGGAAGCCGACGATCCAAATGCCGTGTGTCACCAACCCCGCTTCTGCCACTGGCGGCTTCCCTT CTTGGCTCTTGGGGGGGACTAGATCCTGTGGAGAAGATGACTTAAACTTTGCTTTTTGTTTTAATTTTAATTCTATAACTTGAGATCTTT CCGGGGCCTACAGGCGTGTAAGACAGCTTGGTCTGGTCTGTGCAGAAGTGGGGAGTGATGGGCAGGTTCGGCAGCCTAACATTGTTCAGG CGCATGGCCCCTGCGGTGTGTACACGAACTCGGCTTCTTTTGTCCTAGGTACGCCAAGGGCAGGTTTCTGGAGACTCCCTTGTGCCCGGG ATGGCAAGGGCACCGGGCTGGCGTTTCCACATCTGTCTTCATTAGCAGAAAAGTGATGATGGATTTTATTTCACTCACACTCCAGTTTGT AATAAAATGCCAAATTCTGTCAGCTATCCAAACAAGCCACCATTTGTTCTTGTTGCTTCTCTGGATCCAGAAATGTTGCCATTCTTGGAA ACTGTCCCATTGCTTCGTATTTCTGCCAACGTAGCTCTGCCTGCCTGTCAACCCCTCACTGCACTCTGCTCATCACGGGAGGATACCTGT GTGCCGGCAGCCCCTCAGGGACTCTCAGCCCTGGCACTGGCACCCCAGGGTTGGCCCCGTCAGCAGAGGCTTGGCTTTCGAGCCAGTGGG TGTCTCTCCTTTGGGCCTGGGCGGCTTGCTCCTGCCAGCCATGCCTTCAGGGTAGGCTCTGAGCAAGCTGGCGAACAGCCCTGGCTGCTC CAAAACCAAAAAGCTGGGTCCTCTGGAGGAGGGGCGAGCTGTGGAGCAGCCACCCACTGCTGCCCCAAGCTCACTCAGGAATTCACACCC GCCTGGTTTCTTGAAGTGTGCTGGGTCCTTCCCTCTGCTCCCTACTCCCCACCACGGCAGAGAATAGGCTTTCTAAGATGCTGCGATCCC |
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FusionGenePPI for KLHL22_UBE2L3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KLHL22 | COPS5, COPS6, KLHL13, UBXN7, FAF1, UBXN1, CUL3, DCUN1D1, NEDD8, HSP90AA1, PLK1, KLHL9, NTRK1, GLUD2, SCARF2, LYRM4, METTL15, ATG4C, KLHL20, SCAF8, NFS1, C7orf55, MICU2, ATPAF2, KLHL26, MICU1, NDUFAF5, NUDCD3, NDUFB9, TRMT6, TMEM223, LYRM7, NOB1, GMNN, RBM15B, NOA1, GBAS, RBM14-RBM4, ZBTB34, CIZ1, EMC7, GLUD1, GFER, ZBTB33, POLDIP3, CCL21, LYRM5, BRCA1 | UBE2L3 | UBOX5, AURKA, BRCA1, RNF216, EIF4E2, ARIH1, PTEN, NEDD4, UBE3A, ARIH2, CUL9, CBL, RNF19A, POLR2A, SMURF2, ITCH, WWP2, UBASH3A, RNF125, RNF144B, RNF113B, RNF144A, RBCK1, TRAF7, DTX3, CBLC, MID1, MKRN3, TRIM39, RNF19B, BIRC2, BIRC3, XIAP, PARK2, MYC, MAPK6, ATXN3, ELAVL1, NFKBIA, FOS, NCOA1, UBA1, RELA, SMAD7, RNF103, NR3C1, HACE1, HUWE1, TRIM28, PJA1, TRAF6, NEDD4L, TRIM21, MDM2, STUB1, FBXO2, RNF2, UBE3C, HERC3, TRIP12, WWP1, UBE2D2, AHCYL1, NDUFA7, USP9X, USP34, ZPR1, C12orf5, UBE2B, USP26, SRPRB, UBXN7, TSNAXIP1, UBE2V2, SF1, MRPL53, YAP1, UCHL3, VDAC2, PSMD2, SUGP1, PSMA5, UBE4B, UBXN1, LIG4, FN1, CCNB1IP1, RBX1, AICDA, HSPA4, BAG3, MAP1LC3B, CACNA1B, UBR5, SMURF1, UBA6, UBC, UBE2L3, MUL1, TP53BP1, UBA7, RNF20, HECW2, RNF31, HSPE1, RAB10, SNX12, SNX3, ACAT2, DAZAP1, HEBP1, MDH2, MMACHC, MSI2, PCK2, PIR, PITPNA, PTRHD1, SOD1, UBE2A, UFM1, NDFIP1, AREL1, CACNA1A, RC3H1, HECW1, MCM2, OTUB1, HERC4, HERC6, DUSP4, DUSP8, DNM1L, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KLHL22_UBE2L3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLHL22_UBE2L3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | UBE2L3 | C0524909 | Hepatitis B, Chronic | 1 | CTD_human |
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