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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18968

FusionGeneSummary for KLC4_LCK

check button Fusion gene summary
Fusion gene informationFusion gene name: KLC4_LCK
Fusion gene ID: 18968
HgeneTgene
Gene symbol

KLC4

LCK

Gene ID

89953

3932

Gene namekinesin light chain 4LCK proto-oncogene, Src family tyrosine kinase
SynonymsKNSL8|bA387M24.3IMD22|LSK|YT16|p56lck|pp58lck
Cytomap

6p21.1

1p35.2

Type of geneprotein-codingprotein-coding
Descriptionkinesin light chain 4kinesin-like protein 8tyrosine-protein kinase LckT-lymphocyte specific protein tyrosine kinase p56lckleukocyte C-terminal Src kinaselymphocyte cell-specific protein-tyrosine kinasep56(LSTRA) protein-tyrosine kinaseproto-oncogene tyrosine-protein kinase LCKt cell-specific
Modification date2018052220180527
UniProtAcc

Q9NSK0

P06239

Ensembl transtripts involved in fusion geneENST00000347162, ENST00000453940, 
ENST00000458460, ENST00000259708, 
ENST00000479388, ENST00000394056, 
ENST00000394058, 
ENST00000336890, 
ENST00000333070, ENST00000373564, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 4 X 5=120
# samples 26
** MAII scorelog2(2/4*10)=2.32192809488736log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLC4 [Title/Abstract] AND LCK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLCK

GO:0006468

protein phosphorylation

214242

TgeneLCK

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

16116473

TgeneLCK

GO:0042493

response to drug

16116473

TgeneLCK

GO:0050870

positive regulation of T cell activation

8943371


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA778926KLC4chr6

43042760

-LCKchr1

32719134

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000347162ENST00000336890KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000347162ENST00000333070KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000347162ENST00000373564KLC4chr6

43042760

-LCKchr1

32719134

-
intron-intronENST00000453940ENST00000336890KLC4chr6

43042760

-LCKchr1

32719134

-
intron-intronENST00000453940ENST00000333070KLC4chr6

43042760

-LCKchr1

32719134

-
intron-intronENST00000453940ENST00000373564KLC4chr6

43042760

-LCKchr1

32719134

-
intron-intronENST00000458460ENST00000336890KLC4chr6

43042760

-LCKchr1

32719134

-
intron-intronENST00000458460ENST00000333070KLC4chr6

43042760

-LCKchr1

32719134

-
intron-intronENST00000458460ENST00000373564KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000259708ENST00000336890KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000259708ENST00000333070KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000259708ENST00000373564KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000479388ENST00000336890KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000479388ENST00000333070KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000479388ENST00000373564KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000394056ENST00000336890KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000394056ENST00000333070KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000394056ENST00000373564KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000394058ENST00000336890KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000394058ENST00000333070KLC4chr6

43042760

-LCKchr1

32719134

-
3UTR-intronENST00000394058ENST00000373564KLC4chr6

43042760

-LCKchr1

32719134

-

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FusionProtFeatures for KLC4_LCK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLC4

Q9NSK0

LCK

P06239

Kinesin is a microtubule-associated force-producingprotein that may play a role in organelle transport. The lightchain may function in coupling of cargo to the heavy chain or inthe modulation of its ATPase activity (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLC4_LCK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLC4_LCK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLC4_LCK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneLCKP06239DB09079NintedanibTyrosine-protein kinase Lcksmall moleculeapproved
TgeneLCKP06239DB01254DasatinibTyrosine-protein kinase Lcksmall moleculeapproved|investigational
TgeneLCKP06239DB08901PonatinibTyrosine-protein kinase Lcksmall moleculeapproved|investigational

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RelatedDiseases for KLC4_LCK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLCKC4014233IMMUNODEFICIENCY 221ORPHANET;UNIPROT