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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18967

FusionGeneSummary for KLC4_CTSS

check button Fusion gene summary
Fusion gene informationFusion gene name: KLC4_CTSS
Fusion gene ID: 18967
HgeneTgene
Gene symbol

KLC4

CTSS

Gene ID

89953

1520

Gene namekinesin light chain 4cathepsin S
SynonymsKNSL8|bA387M24.3-
Cytomap

6p21.1

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionkinesin light chain 4kinesin-like protein 8cathepsin S
Modification date2018052220180527
UniProtAcc

Q9NSK0

P25774

Ensembl transtripts involved in fusion geneENST00000347162, ENST00000453940, 
ENST00000458460, ENST00000259708, 
ENST00000479388, ENST00000394056, 
ENST00000394058, 		ENST00000368985, 
ENST00000448301, ENST00000480760, 
Fusion gene scores* DoF score2 X 2 X 1=412 X 10 X 8=960
# samples 212
** MAII scorelog2(2/4*10)=2.32192809488736log2(12/960*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLC4 [Title/Abstract] AND CTSS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCTSS

GO:0006508

proteolysis

12788072|22864553

TgeneCTSS

GO:0010447

response to acidic pH

22864553

TgeneCTSS

GO:0016485

protein processing

22864553

TgeneCTSS

GO:0030574

collagen catabolic process

22952693

TgeneCTSS

GO:0034769

basement membrane disassembly

22952693

TgeneCTSS

GO:0048002

antigen processing and presentation of peptide antigen

8612130

TgeneCTSS

GO:0051603

proteolysis involved in cellular protein catabolic process

22952693

TgeneCTSS

GO:2001259

positive regulation of cation channel activity

22864553


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF858624KLC4chr6

43035030

+CTSSchr1

150705514

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000347162ENST00000368985KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-3UTRENST00000347162ENST00000448301KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-intronENST00000347162ENST00000480760KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-3UTRENST00000453940ENST00000368985KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-3UTRENST00000453940ENST00000448301KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-intronENST00000453940ENST00000480760KLC4chr6

43035030

+CTSSchr1

150705514

-
3UTR-3UTRENST00000458460ENST00000368985KLC4chr6

43035030

+CTSSchr1

150705514

-
3UTR-3UTRENST00000458460ENST00000448301KLC4chr6

43035030

+CTSSchr1

150705514

-
3UTR-intronENST00000458460ENST00000480760KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-3UTRENST00000259708ENST00000368985KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-3UTRENST00000259708ENST00000448301KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-intronENST00000259708ENST00000480760KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-3UTRENST00000479388ENST00000368985KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-3UTRENST00000479388ENST00000448301KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-intronENST00000479388ENST00000480760KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-3UTRENST00000394056ENST00000368985KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-3UTRENST00000394056ENST00000448301KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-intronENST00000394056ENST00000480760KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-3UTRENST00000394058ENST00000368985KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-3UTRENST00000394058ENST00000448301KLC4chr6

43035030

+CTSSchr1

150705514

-
intron-intronENST00000394058ENST00000480760KLC4chr6

43035030

+CTSSchr1

150705514

-

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FusionProtFeatures for KLC4_CTSS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLC4

Q9NSK0

CTSS

P25774

Kinesin is a microtubule-associated force-producingprotein that may play a role in organelle transport. The lightchain may function in coupling of cargo to the heavy chain or inthe modulation of its ATPase activity (By similarity).{ECO:0000250}. Thiol protease. Key protease responsible for the removalof the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to thespecificities of cathepsin L.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLC4_CTSS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLC4_CTSS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLC4_CTSS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KLC4_CTSS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCTSSC0011616Contact Dermatitis1CTD_human
TgeneCTSSC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCTSSC0027626Neoplasm Invasiveness1CTD_human
TgeneCTSSC0028754Obesity1CTD_human