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Fusion gene ID: 18922 |
FusionGeneSummary for KIF5C_SOD2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: KIF5C_SOD2 | Fusion gene ID: 18922 | Hgene | Tgene | Gene symbol | KIF5C | SOD2 | Gene ID | 3800 | 6648 |
Gene name | kinesin family member 5C | superoxide dismutase 2 | |
Synonyms | CDCBM2|KINN|NKHC|NKHC-2|NKHC2 | IPO-B|IPOB|MNSOD|MVCD6|Mn-SOD | |
Cytomap | 2q23.1-q23.2 | 6q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | kinesin heavy chain isoform 5Ckinesin heavy chainkinesin heavy chain neuron-specific 2 | superoxide dismutase [Mn], mitochondrialMn superoxide dismutaseindophenoloxidase Bmanganese-containing superoxide dismutasemangano-superoxide dismutasesuperoxide dismutase 2, mitochondrial | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | O60282 | P04179 | |
Ensembl transtripts involved in fusion gene | ENST00000435030, ENST00000414838, ENST00000464066, ENST00000397413, | ENST00000546087, ENST00000538183, ENST00000367055, ENST00000367054, ENST00000444946, ENST00000337404, ENST00000452684, ENST00000535372, | |
Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 6 X 7 X 2=84 |
# samples | 6 | 9 | |
** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/84*10)=0.0995356735509144 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: KIF5C [Title/Abstract] AND SOD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SOD2 | GO:0006801 | superoxide metabolic process | 12551919|14980699 |
Tgene | SOD2 | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation | 27021683 |
Tgene | SOD2 | GO:1905461 | positive regulation of vascular associated smooth muscle cell apoptotic process | 27021683 |
Tgene | SOD2 | GO:1905932 | positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching | 27021683 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CD365980 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000435030 | ENST00000546087 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000435030 | ENST00000538183 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000435030 | ENST00000367055 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000435030 | ENST00000367054 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000435030 | ENST00000444946 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000435030 | ENST00000337404 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000435030 | ENST00000452684 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000435030 | ENST00000535372 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000414838 | ENST00000546087 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000414838 | ENST00000538183 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000414838 | ENST00000367055 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000414838 | ENST00000367054 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000414838 | ENST00000444946 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000414838 | ENST00000337404 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000414838 | ENST00000452684 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000414838 | ENST00000535372 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000464066 | ENST00000546087 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000464066 | ENST00000538183 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000464066 | ENST00000367055 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000464066 | ENST00000367054 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000464066 | ENST00000444946 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000464066 | ENST00000337404 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000464066 | ENST00000452684 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000464066 | ENST00000535372 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000397413 | ENST00000546087 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000397413 | ENST00000538183 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000397413 | ENST00000367055 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-3CDS | ENST00000397413 | ENST00000367054 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000397413 | ENST00000444946 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000397413 | ENST00000337404 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000397413 | ENST00000452684 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
intron-intron | ENST00000397413 | ENST00000535372 | KIF5C | chr2 | 149639327 | + | SOD2 | chr6 | 160105955 | + |
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FusionProtFeatures for KIF5C_SOD2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
KIF5C | SOD2 |
Involved in synaptic transmission (PubMed:24812067).Mediates dendritic trafficking of mRNAs (By similarity). Kinesinis a microtubule-associated force-producing protein that may playa role in organelle transport. {ECO:0000250|UniProtKB:P28738,ECO:0000269|PubMed:24812067}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KIF5C_SOD2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KIF5C_SOD2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIF5C_SOD2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIF5C_SOD2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KIF5C | C0025958 | Microcephaly | 1 | CTD_human |
Hgene | KIF5C | C1955869 | Malformations of Cortical Development | 1 | CTD_human |
Hgene | KIF5C | C3809013 | CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 2 | 1 | UNIPROT |
Tgene | SOD2 | C0033578 | Prostatic Neoplasms | 7 | CTD_human |
Tgene | SOD2 | C0027626 | Neoplasm Invasiveness | 6 | CTD_human |
Tgene | SOD2 | C0035126 | Reperfusion Injury | 6 | CTD_human |
Tgene | SOD2 | C0007621 | Neoplastic Cell Transformation | 5 | CTD_human |
Tgene | SOD2 | C0018801 | Heart failure | 5 | CTD_human |
Tgene | SOD2 | C0025500 | Mesothelioma | 4 | CTD_human |
Tgene | SOD2 | C0027627 | Neoplasm Metastasis | 4 | CTD_human |
Tgene | SOD2 | C0036341 | Schizophrenia | 4 | PSYGENET |
Tgene | SOD2 | C0037286 | Skin Neoplasms | 4 | CTD_human |
Tgene | SOD2 | C0038356 | Stomach Neoplasms | 4 | CTD_human |
Tgene | SOD2 | C1458155 | Mammary Neoplasms | 4 | CTD_human |
Tgene | SOD2 | C2239176 | Liver carcinoma | 4 | CTD_human |
Tgene | SOD2 | C0003873 | Rheumatoid Arthritis | 3 | CTD_human |
Tgene | SOD2 | C0007786 | Brain Ischemia | 3 | CTD_human |
Tgene | SOD2 | C0020538 | Hypertensive disease | 3 | CTD_human |
Tgene | SOD2 | C0024232 | Lymphatic Metastasis | 3 | CTD_human |
Tgene | SOD2 | C0029408 | Degenerative polyarthritis | 3 | CTD_human |
Tgene | SOD2 | C0030567 | Parkinson Disease | 3 | CTD_human |
Tgene | SOD2 | C0524851 | Neurodegenerative Disorders | 3 | CTD_human |
Tgene | SOD2 | C0002896 | Sideroblastic anemia | 2 | CTD_human |
Tgene | SOD2 | C0004153 | Atherosclerosis | 2 | CTD_human |
Tgene | SOD2 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Tgene | SOD2 | C0005695 | Bladder Neoplasm | 2 | CTD_human |
Tgene | SOD2 | C0007131 | Non-Small Cell Lung Carcinoma | 2 | CTD_human |
Tgene | SOD2 | C0007137 | Squamous cell carcinoma | 2 | CTD_human |
Tgene | SOD2 | C0007193 | Cardiomyopathy, Dilated | 2 | CTD_human |
Tgene | SOD2 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
Tgene | SOD2 | C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human |
Tgene | SOD2 | C0014859 | Esophageal Neoplasms | 2 | CTD_human |
Tgene | SOD2 | C0022116 | Ischemia | 2 | CTD_human |
Tgene | SOD2 | C0022658 | Kidney Diseases | 2 | CTD_human |
Tgene | SOD2 | C0026640 | Mouth Neoplasms | 2 | CTD_human |
Tgene | SOD2 | C0027540 | Necrosis | 2 | CTD_human |
Tgene | SOD2 | C0028754 | Obesity | 2 | CTD_human |
Tgene | SOD2 | C0032927 | Precancerous Conditions | 2 | CTD_human |
Tgene | SOD2 | C0042164 | Uveitis | 2 | CTD_human |
Tgene | SOD2 | C0162674 | Chronic progressive external ophthalmoplegia | 2 | CTD_human |
Tgene | SOD2 | C0242184 | Hypoxia | 2 | CTD_human |
Tgene | SOD2 | C0279626 | Squamous cell carcinoma of esophagus | 2 | CTD_human |
Tgene | SOD2 | C0919267 | ovarian neoplasm | 2 | CTD_human |
Tgene | SOD2 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | SOD2 | C0001925 | Albuminuria | 1 | CTD_human |
Tgene | SOD2 | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
Tgene | SOD2 | C0002390 | Extrinsic allergic alveolitis | 1 | CTD_human |
Tgene | SOD2 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
Tgene | SOD2 | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human |
Tgene | SOD2 | C0002871 | Anemia | 1 | CTD_human |
Tgene | SOD2 | C0003493 | Aortic Diseases | 1 | CTD_human |
Tgene | SOD2 | C0004045 | Asphyxia Neonatorum | 1 | CTD_human |
Tgene | SOD2 | C0004364 | Autoimmune Diseases | 1 | CTD_human |
Tgene | SOD2 | C0006118 | Brain Neoplasms | 1 | CTD_human |
Tgene | SOD2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | SOD2 | C0007682 | CNS disorder | 1 | CTD_human |
Tgene | SOD2 | C0007787 | Transient Ischemic Attack | 1 | CTD_human |
Tgene | SOD2 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Tgene | SOD2 | C0011570 | Mental Depression | 1 | PSYGENET |
Tgene | SOD2 | C0011581 | Depressive disorder | 1 | PSYGENET |
Tgene | SOD2 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Tgene | SOD2 | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
Tgene | SOD2 | C0014866 | Esophageal Stenosis | 1 | CTD_human |
Tgene | SOD2 | C0014868 | Esophagitis | 1 | CTD_human |
Tgene | SOD2 | C0015695 | Fatty Liver | 1 | CTD_human |
Tgene | SOD2 | C0015967 | Fever | 1 | CTD_human |
Tgene | SOD2 | C0016059 | Fibrosis | 1 | CTD_human |
Tgene | SOD2 | C0018200 | Granuloma, Respiratory Tract | 1 | CTD_human |
Tgene | SOD2 | C0018800 | Cardiomegaly | 1 | CTD_human |
Tgene | SOD2 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
Tgene | SOD2 | C0020550 | Hyperthyroidism | 1 | CTD_human |
Tgene | SOD2 | C0020615 | Hypoglycemia | 1 | CTD_human |
Tgene | SOD2 | C0021364 | Male infertility | 1 | CTD_human |
Tgene | SOD2 | C0021655 | Insulin Resistance | 1 | CTD_human |
Tgene | SOD2 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
Tgene | SOD2 | C0022672 | Acute Kidney Tubular Necrosis | 1 | CTD_human |
Tgene | SOD2 | C0023891 | Liver Cirrhosis, Alcoholic | 1 | CTD_human |
Tgene | SOD2 | C0024115 | Lung diseases | 1 | CTD_human |
Tgene | SOD2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | SOD2 | C0024796 | Marfan Syndrome | 1 | CTD_human |
Tgene | SOD2 | C0025312 | Meningomyelocele | 1 | CTD_human |
Tgene | SOD2 | C0026764 | Multiple Myeloma | 1 | CTD_human |
Tgene | SOD2 | C0027051 | Myocardial Infarction | 1 | CTD_human |
Tgene | SOD2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
Tgene | SOD2 | C0027746 | Nerve Degeneration | 1 | CTD_human |
Tgene | SOD2 | C0029456 | Osteoporosis | 1 | CTD_human |
Tgene | SOD2 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
Tgene | SOD2 | C0030354 | Papilloma | 1 | CTD_human |
Tgene | SOD2 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Tgene | SOD2 | C0032580 | Adenomatous Polyposis Coli | 1 | CTD_human |
Tgene | SOD2 | C0033860 | Psoriasis | 1 | CTD_human |
Tgene | SOD2 | C0033941 | Psychoses, Substance-Induced | 1 | CTD_human |
Tgene | SOD2 | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
Tgene | SOD2 | C0036202 | Sarcoidosis | 1 | CTD_human |
Tgene | SOD2 | C0036572 | Seizures | 1 | CTD_human |
Tgene | SOD2 | C0036980 | Shock, Cardiogenic | 1 | CTD_human |
Tgene | SOD2 | C0037268 | Skin Abnormalities | 1 | CTD_human |
Tgene | SOD2 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Tgene | SOD2 | C0040411 | Tongue Neoplasms | 1 | CTD_human |
Tgene | SOD2 | C0041408 | Turner Syndrome | 1 | CTD_human |
Tgene | SOD2 | C0042373 | Vascular Diseases | 1 | CTD_human |
Tgene | SOD2 | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
Tgene | SOD2 | C0085207 | Gestational Diabetes | 1 | CTD_human |
Tgene | SOD2 | C0151526 | Premature Birth | 1 | CTD_human |
Tgene | SOD2 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | SOD2 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Tgene | SOD2 | C0162309 | Adrenoleukodystrophy | 1 | CTD_human |
Tgene | SOD2 | C0162671 | MELAS Syndrome | 1 | CTD_human |
Tgene | SOD2 | C0162871 | Aortic Aneurysm, Abdominal | 1 | CTD_human |
Tgene | SOD2 | C0206062 | Lung Diseases, Interstitial | 1 | CTD_human |
Tgene | SOD2 | C0206160 | Reticulocytosis | 1 | CTD_human |
Tgene | SOD2 | C0235974 | Pancreatic carcinoma | 1 | CTD_human |
Tgene | SOD2 | C0238461 | Anaplastic thyroid carcinoma | 1 | CTD_human |
Tgene | SOD2 | C0242698 | Ventricular Dysfunction, Left | 1 | CTD_human |
Tgene | SOD2 | C0242992 | Multiple Chemical Sensitivity | 1 | CTD_human |
Tgene | SOD2 | C0268255 | Farber Lipogranulomatosis | 1 | CTD_human |
Tgene | SOD2 | C0268583 | Methylmalonic acidemia | 1 | CTD_human |
Tgene | SOD2 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
Tgene | SOD2 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Tgene | SOD2 | C0376618 | Endotoxemia | 1 | CTD_human |
Tgene | SOD2 | C0520459 | Necrotizing Enterocolitis | 1 | CTD_human |
Tgene | SOD2 | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
Tgene | SOD2 | C0751651 | Mitochondrial Diseases | 1 | CTD_human |
Tgene | SOD2 | C0752347 | Lewy Body Disease | 1 | CTD_human |
Tgene | SOD2 | C0878544 | Cardiomyopathies | 1 | CTD_human |
Tgene | SOD2 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Tgene | SOD2 | C1134719 | Invasive Ductal Breast Carcinoma | 1 | CTD_human |
Tgene | SOD2 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
Tgene | SOD2 | C1269683 | Major Depressive Disorder | 1 | CTD_human |
Tgene | SOD2 | C1859317 | Cataract and cardiomyopathy | 1 | CTD_human |
Tgene | SOD2 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |
Tgene | SOD2 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |