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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18916

FusionGeneSummary for KIF5B_MET

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF5B_MET
Fusion gene ID: 18916
HgeneTgene
Gene symbol

KIF5B

MET

Gene ID

3799

8731

Gene namekinesin family member 5BRNA guanine-7 methyltransferase
SynonymsHEL-S-61|KINH|KNS|KNS1|UKHCCMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet
Cytomap

10p11.22

18p11.21

Type of geneprotein-codingprotein-coding
Descriptionkinesin-1 heavy chainconventional kinesin heavy chainepididymis secretory protein Li 61kinesin 1 (110-120kD)kinesin heavy chainubiquitous kinesin heavy chainmRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase
Modification date2018052320180523
UniProtAcc

P33176

P08581

Ensembl transtripts involved in fusion geneENST00000302418, ENST00000493889, 
ENST00000397752, ENST00000318493, 
ENST00000436117, ENST00000495962, 
ENST00000539704, 
Fusion gene scores* DoF score7 X 7 X 6=29411 X 10 X 9=990
# samples 1920
** MAII scorelog2(19/294*10)=-0.629816736505416
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/990*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF5B [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIF5B

GO:0042391

regulation of membrane potential

19675065

HgeneKIF5B

GO:0043268

positive regulation of potassium ion transport

19675065

HgeneKIF5B

GO:0047496

vesicle transport along microtubule

28426968

HgeneKIF5B

GO:1903078

positive regulation of protein localization to plasma membrane

19675065

TgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-93-A4JN-01AKIF5Bchr10

32306071

-METchr7

116411903

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000302418ENST00000397752KIF5Bchr10

32306071

-METchr7

116411903

+
Frame-shiftENST00000302418ENST00000318493KIF5Bchr10

32306071

-METchr7

116411903

+
5CDS-intronENST00000302418ENST00000436117KIF5Bchr10

32306071

-METchr7

116411903

+
5CDS-intronENST00000302418ENST00000495962KIF5Bchr10

32306071

-METchr7

116411903

+
5CDS-intronENST00000302418ENST00000539704KIF5Bchr10

32306071

-METchr7

116411903

+
intron-3CDSENST00000493889ENST00000397752KIF5Bchr10

32306071

-METchr7

116411903

+
intron-3CDSENST00000493889ENST00000318493KIF5Bchr10

32306071

-METchr7

116411903

+
intron-intronENST00000493889ENST00000436117KIF5Bchr10

32306071

-METchr7

116411903

+
intron-intronENST00000493889ENST00000495962KIF5Bchr10

32306071

-METchr7

116411903

+
intron-intronENST00000493889ENST00000539704KIF5Bchr10

32306071

-METchr7

116411903

+

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FusionProtFeatures for KIF5B_MET


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF5B

P33176

MET

P08581

Microtubule-dependent motor required for normaldistribution of mitochondria and lysosomes. Can induce formationof neurite-like membrane protrusions in non-neuronal cells in aZFYVE27-dependent manner (By similarity). Regulates centrosome andnuclear positioning during mitotic entry. During the G2 phase ofthe cell cycle in a BICD2-dependent manner, antagonizes dyneinfunction and drives the separation of nuclei and centrosomes(PubMed:20386726). {ECO:0000250|UniProtKB:Q61768,ECO:0000269|PubMed:20386726}. Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding tohepatocyte growth factor/HGF ligand. Regulates many physiologicalprocesses including proliferation, scattering, morphogenesis andsurvival. Ligand binding at the cell surface inducesautophosphorylation of MET on its intracellular domain thatprovides docking sites for downstream signaling molecules.Following activation by ligand, interacts with the PI3-kinasesubunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.Recruitment of these downstream effectors by MET leads to theactivation of several signaling cascades including the RAS-ERK,PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation isassociated with the morphogenetic effects while PI3K/AKTcoordinates prosurvival effects. During embryonic development, METsignaling plays a role in gastrulation, development and migrationof muscles and neuronal precursors, angiogenesis and kidneyformation. In adults, participates in wound healing as well asorgan regeneration and tissue remodeling. Promotes alsodifferentiation and proliferation of hematopoietic cells. Mayregulate cortical bone osteogenesis (By similarity).{ECO:0000250|UniProtKB:P16056}. Acts as a receptor for Listeria internalin inlB,mediating entry of the pathogen into cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIF5B_MET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIF5B_MET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF5BYWHAG, YWHAB, YWHAQ, YWHAZ, VDAC1, NME2, SFN, DTNB, SNAP23, SNAP25, KLC1, KLC2, KIF5C, YWHAH, USPL1, MARK2, MEPCE, FYCO1, RAPGEF2, APC, SPG20, CDC5L, GSK3B, NDRG1, SIRT7, RANBP2, KIAA0368, KLC4, ZBTB8B, KDM1A, MCCC1, EXOC7, DHX9, TWF1, SRP68, RNF168, YWHAE, CFTR, ACACA, CAST, COPE, COPS5, AKAP2, DIAPH1, ELP2, EPB41L1, NUP50, RNF20, PSMA2, PSMA4, PSMA5, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSME1, PTPN23, RABGAP1, SMEK2, TRIM25, STAU1, AURKB, HUWE1, PRKAR2B, VPS52, TAX1BP1, ZBTB8A, CUL7, EZH2, ABCE1, TRAK2, CCDC101, SYNE4, DTNBP1, NUP43, KPTN, AZIN1, TRIP6, CHRNA9, RPS6KB2, KIF1A, LSM2, NTRK1, MED4, L1TD1, KLC3, NHS, POU1F1, TUBA1A, OGT, SQSTM1, XPR1, NCOR1, TRAK1, KIDINS220, SLC38A10, FOXQ1, CDH1, MYCL, COG6, EXOC1, MAP7D2, HOMER1, DLST, SOD1, BRCA1METGLMN, CDH1, CTNNB1, HGF, RANBP9, GRB2, CBL, SH3KBP1, RANBP10, SRC, SHC1, SOS1, STAT3, GAB1, GAB2, LRIG1, INPPL1, DCN, SPSB1, SPSB2, SPSB3, SPSB4, CBLC, STUB1, HSPA4, HSP90AA1, GGA3, GNG12, FBXO6, HGS, CRK, CEACAM21, LGALS9, PCBP1, CASP3, SOCS1, HSP90AB1, EGFR, ERBB3, MET, CHEK1, PTEN, SCGB1D1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF5B_MET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMETP08581DB08865CrizotinibHepatocyte growth factor receptorsmall moleculeapproved
TgeneMETP08581DB08875CabozantinibHepatocyte growth factor receptorsmall moleculeapproved|investigational

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RelatedDiseases for KIF5B_MET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF5BC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneKIF5BC0011849Diabetes Mellitus1CTD_human
TgeneMETC1336839Type 1 Papillary Renal Cell Carcinoma5UNIPROT
TgeneMETC0007131Non-Small Cell Lung Carcinoma4CTD_human
TgeneMETC0001418Adenocarcinoma2CTD_human
TgeneMETC0004352Autistic Disorder2CTD_human
TgeneMETC0027627Neoplasm Metastasis2CTD_human
TgeneMETC0038356Stomach Neoplasms2CTD_human
TgeneMETC0004114Astrocytoma1CTD_human
TgeneMETC0007134Renal Cell Carcinoma1CTD_human
TgeneMETC0007137Squamous cell carcinoma1CTD_human
TgeneMETC0009241Cognition Disorders1CTD_human
TgeneMETC0014859Esophageal Neoplasms1CTD_human
TgeneMETC0017636Glioblastoma1CTD_human
TgeneMETC0019189Hepatitis, Chronic1CTD_human
TgeneMETC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneMETC0023904Liver Neoplasms, Experimental1CTD_human
TgeneMETC0024121Lung Neoplasms1CTD_human
TgeneMETC0027626Neoplasm Invasiveness1CTD_human
TgeneMETC0027819Neuroblastoma1CTD_human
TgeneMETC0029463Osteosarcoma1CTD_human
TgeneMETC0036341Schizophrenia1CTD_human
TgeneMETC0037199Sinusitis1CTD_human
TgeneMETC0345967Malignant mesothelioma1CTD_human
TgeneMETC0919267ovarian neoplasm1CTD_human
TgeneMETC1876165Copper-Overload Cirrhosis1CTD_human
TgeneMETC2239176Liver carcinoma1CTD_human;HPO;UNIPROT
TgeneMETC4084709DEAFNESS, AUTOSOMAL RECESSIVE 971UNIPROT