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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18906

FusionGeneSummary for KIF3C_SRM

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF3C_SRM
Fusion gene ID: 18906
HgeneTgene
Gene symbol

KIF3C

SRM

Gene ID

3797

6723

Gene namekinesin family member 3Cspermidine synthase
Synonyms-PAPT|SPDSY|SPS1|SRML1
Cytomap

2p23.3

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF3CKIF3C variant proteinspermidine synthaseputrescine aminopropyltransferasespermidine synthase-1
Modification date2018052320180523
UniProtAcc

O14782

P19623

Ensembl transtripts involved in fusion geneENST00000264712, ENST00000405914, 
ENST00000496378, 
ENST00000376957, 
Fusion gene scores* DoF score7 X 4 X 4=1123 X 2 X 3=18
# samples 73
** MAII scorelog2(7/112*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIF3C [Title/Abstract] AND SRM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSRM

GO:0008295

spermidine biosynthetic process

17585781


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N8-A4PL-01AKIF3Cchr2

26203242

-SRMchr1

11119402

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000264712ENST00000376957KIF3Cchr2

26203242

-SRMchr1

11119402

-
In-frameENST00000405914ENST00000376957KIF3Cchr2

26203242

-SRMchr1

11119402

-
intron-3CDSENST00000496378ENST00000376957KIF3Cchr2

26203242

-SRMchr1

11119402

-

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FusionProtFeatures for KIF3C_SRM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF3C

O14782

SRM

P19623

Microtubule-based anterograde translocator formembranous organelles. {ECO:0000250}. Catalyzes the production of spermidine from putrescineand decarboxylated S-adenosylmethionine (dcSAM). Has a strongpreference for putrescine as substrate, and has very low activitytowards 1,3-diaminopropane. Has extremely low activity towardsspermidine. {ECO:0000269|PubMed:17585781}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIF3C_SRM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KIF3C_ENST00000405914_chr2_26203242_-_SRM_ENST00000376957_chr1_11119402_-_762aa
MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFN
GTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDL
SSFVTKNVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAGGAATPSSG
GGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFAN
RAKNIKNKPQVNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILE
SALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKXDLWQRAGVGRCHPVHGERRVLLPG
DDRQPASLQPPQPAKGADHRGRRWRCPAGGGEAPLRGVRGPVXDRRGCHPSLQEVPARHGHWLLXLEADPTCGXRFXVHETESGCLRRDH
HXLLRPHGPRRKSLQGVLLPAHEDSPQGRWCPLLPGRVPVAAPGPHQGDAAVLPVPVPRGGLCLLHHPHLPQRPDRLHAVQQEPEHELPG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KIF3C_ENST00000405914_chr2_26203242_-_SRM_ENST00000376957_chr1_11119402_-_2287nt
ATGGCCAGTAAGACCAAGGCCAGCGAGGCCCTCAAGGTGGTGGCCCGGTGCCGCCCCCTCAGCAGGAAGGAGGAGGCTGCTGGTCACGAG
CAGATCCTGACCATGGACGTGAAACTGGGCCAGGTGACCCTGCGGAACCCCCGCGCCGCCCCGGGGGAGCTGCCCAAGACCTTCACCTTT
GACGCCGTGTATGATGCCAGCTCCAAGCAGGCCGACCTGTATGACGAAACCGTGAGGCCCCTGATAGACTCCGTGCTCCAGGGTTTCAAT
GGCACGGTGTTTGCCTATGGCCAGACGGGCACTGGCAAGACCTATACCATGCAGGGGACCTGGGTGGAGCCCGAGCTGCGCGGGGTCATC
CCGAATGCCTTTGAGCACATCTTCACCCACATCTCCCGCTCCCAGAACCAACAGTACCTGGTCCGGGCCTCCTATTTGGAGATCTACCAG
GAAGAGATTCGAGACCTGCTCTCCAAGGAGCCGGGCAAGAGGCTAGAGCTGAAAGAGAACCCCGAGACTGGCGTCTACATCAAGGACCTC
TCCTCCTTCGTCACCAAGAATGTCAAGGAGATTGAGCATGTGATGAACCTGGGGAACCAGACCCGGGCTGTGGGCAGCACCCACATGAAT
GAGGTCAGCTCCCGCTCCCATGCCATCTTCATCATCACTGTGGAGTGCAGCGAACGTGGCTCTGATGGCCAGGACCACATCCGAGTGGGC
AAGCTCAACCTCGTGGACCTGGCTGGCAGCGAGAGGCAGAACAAGGCAGGCCCCAACACAGCGGGAGGGGCAGCCACACCATCCTCGGGT
GGCGGTGGTGGCGGTGGAGGCAGTGGTGGTGGTGCTGGTGGAGAGAGGCCTAAGGAAGCCTCCAAAATCAACCTCTCATTATCTGCCCTG
GGCAACGTGATTGCTGCCCTGGCGGGCAACAGGAGCACCCACATTCCCTACCGGGACTCCAAGCTGACCCGGCTGCTCCAGGACTCCCTG
GGGGGGAATGCCAAGACCATCATGGTAGCCACACTGGGGCCAGCTTCTCACAGCTACGATGAGAGCCTCTCCACCTTGCGCTTTGCCAAC
CGAGCCAAGAACATCAAGAACAAGCCCCAGGTGAACGAGGACCCCAAGGACACACTGCTGCGGGAATTCCAAGAGGAGATTGCCCGCCTG
AAGGCCCAGCTGGAGAAGAGGGGGATGCTGGGGAAGCGGCCCCGGAGGAAGAGCAGCCGCAGGAAGAAGGCCGTGTCCGCCCCGCCTGGG
TACCCTGAGGGCCCAGTGATTGAGGCCTGGGTGGCAGAAGAGGAGGATGACAACAACAACAACCACCGCCCGCCCCAGCCCATCCTGGAG
TCAGCCTTGGAGAAGAACATGGAGAATTACCTGCAGGAACAGAAGGAGCGGCTGGAGGAGGAGAAGGCAGCCATCCAGGATGACCGCAGC
CTGGTGAGCGAGGAGAAGCAGAAGCTGCTGGAGGAGAAGGAGAAGATGCTGGAGGACCTGCGGCGGGAACAGCAGGCCACAGAGCTGCTT
GCGGCCAAGTACAAGTAAGACCTATGGCAACGTGCTGGTGTTGGACGGTGTCATCCAGTGCACGGAGAGAGACGAGTTCTCCTACCAGGA
GATGATCGCCAACCTGCCTCTCTGCAGCCACCCCAACCCGCGAAAGGTGCTGATCATCGGGGGCGGAGATGGAGGTGTCCTGCGGGAGGT
GGTGAAGCACCCCTCCGTGGAGTCCGTGGTCCAGTGTGAGATCGACGAGGATGTCATCCAAGTCTCCAAGAAGTTCCTGCCAGGCATGGC
CATTGGCTACTCTAGCTCGAAGCTGACCCTACATGTGGGTGACGGTTTTGAGTTCATGAAACAGAATCAGGATGCCTTCGACGTGATCAT
CACTGACTCCTCAGACCCCATGGGCCCCGCCGAAAGTCTCTTCAAGGAGTCCTATTACCAGCTCATGAAGACAGCCCTCAAGGAAGATGG
TGTCCTCTGCTGCCAGGGCGAGTGCCAGTGGCTGCACCTGGACCTCATCAAGGAGATGCGGCAGTTCTGCCAGTCCCTGTTCCCCGTGGT
GGCCTATGCCTACTGCACCATCCCCACCTACCCCAGCGGCCAGATCGGCTTCATGCTGTGCAGCAAGAACCCGAGCACGAACTTCCAGGA
GCCGGTGCAGCCGCTGACACAGCAGCAGGTGGCGCAGATGCAGCTGAAGTACTACAACTCCGACGTGCACCGCGCCGCCTTTGTGCTGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_KIF3C_ENST00000405914_chr2_26203242_-_SRM_ENST00000376957_chr1_11119402_-_3136nt
GGCGGTGGCTGCGCTGCACCCGACTGGTGGGCGCAGGACCTGGGTCGGCACCGGAGCCTGTCATCCCGGAGCGGTCGGCGGGGGTGCAGA
GACGGCGATGCGCCCCTGTCCCCCGCACCCGGGCCGCTCCGGGCTCGCGCCTCCCGCCCCGCGGCCCCGCCCCCTGCCCCACCCCAGTCG
GGAGGCTTAGCTGGGGCCGCAGCGCGGCGGCAACATCACTCTCGCTGCCGCTGCTCCGCCCCATCCCCTTCTGTTTTTCTCTCTCATTCT
CCAGTGGCGGCGGCGGGGAAGGCGGAGGCAGAGGCAGCAGCAGCCGCGCTGGCTGCAATGAATGATCCCCCAGCTTGGGGGGAGGACTCC
AGCCGGTGCAGAGAGGACCGGAGAGCGGTGGAGGCCCGGACTGCAGCAGCGTTGGGGCCACCTCCCAGCGTCCCCACCCTAGGAGGCTGC
ATGCGGATTGAAGAGCTGCGCCTGGGGGCTGGGCCGGCCCCGCTGATCCCGACCTAGCGAGCAGGATAGCAGGACCGCCCAGGCTGCGGA
GGGGCTCGGGGGCAGGAAGGTCAGAGCAGCAAGATGGCCAGTAAGACCAAGGCCAGCGAGGCCCTCAAGGTGGTGGCCCGGTGCCGCCCC
CTCAGCAGGAAGGAGGAGGCTGCTGGTCACGAGCAGATCCTGACCATGGACGTGAAACTGGGCCAGGTGACCCTGCGGAACCCCCGCGCC
GCCCCGGGGGAGCTGCCCAAGACCTTCACCTTTGACGCCGTGTATGATGCCAGCTCCAAGCAGGCCGACCTGTATGACGAAACCGTGAGG
CCCCTGATAGACTCCGTGCTCCAGGGTTTCAATGGCACGGTGTTTGCCTATGGCCAGACGGGCACTGGCAAGACCTATACCATGCAGGGG
ACCTGGGTGGAGCCCGAGCTGCGCGGGGTCATCCCGAATGCCTTTGAGCACATCTTCACCCACATCTCCCGCTCCCAGAACCAACAGTAC
CTGGTCCGGGCCTCCTATTTGGAGATCTACCAGGAAGAGATTCGAGACCTGCTCTCCAAGGAGCCGGGCAAGAGGCTAGAGCTGAAAGAG
AACCCCGAGACTGGCGTCTACATCAAGGACCTCTCCTCCTTCGTCACCAAGAATGTCAAGGAGATTGAGCATGTGATGAACCTGGGGAAC
CAGACCCGGGCTGTGGGCAGCACCCACATGAATGAGGTCAGCTCCCGCTCCCATGCCATCTTCATCATCACTGTGGAGTGCAGCGAACGT
GGCTCTGATGGCCAGGACCACATCCGAGTGGGCAAGCTCAACCTCGTGGACCTGGCTGGCAGCGAGAGGCAGAACAAGGCAGGCCCCAAC
ACAGCGGGAGGGGCAGCCACACCATCCTCGGGTGGCGGTGGTGGCGGTGGAGGCAGTGGTGGTGGTGCTGGTGGAGAGAGGCCTAAGGAA
GCCTCCAAAATCAACCTCTCATTATCTGCCCTGGGCAACGTGATTGCTGCCCTGGCGGGCAACAGGAGCACCCACATTCCCTACCGGGAC
TCCAAGCTGACCCGGCTGCTCCAGGACTCCCTGGGGGGGAATGCCAAGACCATCATGGTAGCCACACTGGGGCCAGCTTCTCACAGCTAC
GATGAGAGCCTCTCCACCTTGCGCTTTGCCAACCGAGCCAAGAACATCAAGAACAAGCCCCAGGTGAACGAGGACCCCAAGGACACACTG
CTGCGGGAATTCCAAGAGGAGATTGCCCGCCTGAAGGCCCAGCTGGAGAAGAGGGGGATGCTGGGGAAGCGGCCCCGGAGGAAGAGCAGC
CGCAGGAAGAAGGCCGTGTCCGCCCCGCCTGGGTACCCTGAGGGCCCAGTGATTGAGGCCTGGGTGGCAGAAGAGGAGGATGACAACAAC
AACAACCACCGCCCGCCCCAGCCCATCCTGGAGTCAGCCTTGGAGAAGAACATGGAGAATTACCTGCAGGAACAGAAGGAGCGGCTGGAG
GAGGAGAAGGCAGCCATCCAGGATGACCGCAGCCTGGTGAGCGAGGAGAAGCAGAAGCTGCTGGAGGAGAAGGAGAAGATGCTGGAGGAC
CTGCGGCGGGAACAGCAGGCCACAGAGCTGCTTGCGGCCAAGTACAAGTAAGACCTATGGCAACGTGCTGGTGTTGGACGGTGTCATCCA
GTGCACGGAGAGAGACGAGTTCTCCTACCAGGAGATGATCGCCAACCTGCCTCTCTGCAGCCACCCCAACCCGCGAAAGGTGCTGATCAT
CGGGGGCGGAGATGGAGGTGTCCTGCGGGAGGTGGTGAAGCACCCCTCCGTGGAGTCCGTGGTCCAGTGTGAGATCGACGAGGATGTCAT
CCAAGTCTCCAAGAAGTTCCTGCCAGGCATGGCCATTGGCTACTCTAGCTCGAAGCTGACCCTACATGTGGGTGACGGTTTTGAGTTCAT
GAAACAGAATCAGGATGCCTTCGACGTGATCATCACTGACTCCTCAGACCCCATGGGCCCCGCCGAAAGTCTCTTCAAGGAGTCCTATTA
CCAGCTCATGAAGACAGCCCTCAAGGAAGATGGTGTCCTCTGCTGCCAGGGCGAGTGCCAGTGGCTGCACCTGGACCTCATCAAGGAGAT
GCGGCAGTTCTGCCAGTCCCTGTTCCCCGTGGTGGCCTATGCCTACTGCACCATCCCCACCTACCCCAGCGGCCAGATCGGCTTCATGCT
GTGCAGCAAGAACCCGAGCACGAACTTCCAGGAGCCGGTGCAGCCGCTGACACAGCAGCAGGTGGCGCAGATGCAGCTGAAGTACTACAA
CTCCGACGTGCACCGCGCCGCCTTTGTGCTGCCCGAGTTTGCCCGCAAGGCCCTGAATGATGTGAGCTGAGCCCAGGCGCCACCACTGAT
GCCACCCAGGACCTCGGACCTTGGAGCCTGCGGGGTGCCTCGGCCCCTCCAGCCCCGGGCCGGACCTCCTGCTGGCTCTCGCCCACCAAC
CAAGTGTTACAAGCCCCAGAATGCTGCCCGGCCTGCCCTGCTGGGCGGACTGTCTGTGTGTCTGTCTCTCTGGCGTTCCACCTCCAAGCC


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FusionGenePPI for KIF3C_SRM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF3CCDC5L, DISC1, KIF3A, KIFAP3, ZC3H3, KIAA1279, AKAP12, STK4, DYRK2, SAV1, KIF3BSRMDMWD, DDA1, TERF1, NT5DC1, VCAM1, FN1, ITGA4, SOX12, MOV10, NXF1, ABCE1, CRK, HK2, AARSD1, PTGES3L-AARSD1, GOLPH3, RPRD1B, TIPRL, NTRK1, CRY2, DUSP1, DUSP19, DUSP28, DUSP4, DUSP6, DUSP9, EFHC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF3C_SRM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF3C_SRM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF3CC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human