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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 18900

FusionGeneSummary for KIF3C_ADCY3

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF3C_ADCY3
Fusion gene ID: 18900
HgeneTgene
Gene symbol

KIF3C

ADCY3

Gene ID

3797

114

Gene namekinesin family member 3Cadenylate cyclase 8
Synonyms-AC8|ADCY3|HBAC1
Cytomap

2p23.3

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF3CKIF3C variant proteinadenylate cyclase type 8ATP pyrophosphate-lyase 8HEL-S-172mPadenylate cyclase 8 (brain)adenylate cyclase type VIIIadenylyl cyclase 8adenylyl cyclase-8, brainca(2+)/calmodulin-activated adenylyl cyclaseepididymis secretory sperm binding protein Li
Modification date2018052320180523
UniProtAcc

O14782

O60266

Ensembl transtripts involved in fusion geneENST00000264712, ENST00000405914, 
ENST00000496378, 		ENST00000260600, 
ENST00000405392, ENST00000450524, 
Fusion gene scores* DoF score7 X 4 X 4=1123 X 3 X 3=27
# samples 73
** MAII scorelog2(7/112*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIF3C [Title/Abstract] AND ADCY3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-59-A5PD-01AKIF3Cchr2

26203242

-ADCY3chr2

25095588

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264712ENST00000260600KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
5CDS-intronENST00000264712ENST00000405392KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
5CDS-intronENST00000264712ENST00000450524KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
Frame-shiftENST00000405914ENST00000260600KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
5CDS-intronENST00000405914ENST00000405392KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
5CDS-intronENST00000405914ENST00000450524KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
intron-3CDSENST00000496378ENST00000260600KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
intron-intronENST00000496378ENST00000405392KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
intron-intronENST00000496378ENST00000450524KIF3Cchr2

26203242

-ADCY3chr2

25095588

-

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FusionProtFeatures for KIF3C_ADCY3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF3C

O14782

ADCY3

O60266

Microtubule-based anterograde translocator formembranous organelles. {ECO:0000250}. Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling. Participates in signalingcascades triggered by odorant receptors via its function in cAMPbiosynthesis. Required for the perception of odorants. Requiredfor normal sperm motility and normal male fertility. Plays a rolein regulating insulin levels and body fat accumulation in responseto a high fat diet. {ECO:0000250|UniProtKB:Q8VHH7}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-18270_284515794Compositional biasNote=Poly-Gly
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-18438_441515794Compositional biasNote=Poly-Asn
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-29270_284515794Compositional biasNote=Poly-Gly
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-29438_441515794Compositional biasNote=Poly-Asn
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-1810_365515794DomainKinesin motor
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-2910_365515794DomainKinesin motor
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-1897_104515794Nucleotide bindingNote=ATP
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-2997_104515794Nucleotide bindingNote=ATP
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-0211062_10642251145Nucleotide bindingATP
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-0211069_10732251145Nucleotide bindingATP
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021324_3292251145Nucleotide bindingATP
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021366_3682251145Nucleotide bindingATP
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021402_6322251145Topological domainCytoplasmic
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021854_11442251145Topological domainCytoplasmic
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021226_2462251145TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021381_4012251145TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021633_6532251145TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021664_6842251145TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021708_7282251145TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021754_7742251145TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021775_7952251145TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021833_8532251145TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-18376_629515794Coiled coilOntology_term=ECO:0000255
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-29376_629515794Coiled coilOntology_term=ECO:0000255
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-18630_793515794RegionGlobular
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-29630_793515794RegionGlobular
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-0211_792251145Topological domainCytoplasmic
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021105_1252251145TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021139_1592251145TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-021173_1932251145TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600-02180_1002251145TransmembraneHelical


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FusionGeneSequence for KIF3C_ADCY3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KIF3C_ENST00000264712_chr2_26203242_-_ADCY3_ENST00000260600_chr2_25095588_-_1435aa
MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFN
GTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDL
SSFVTKNVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAGGAATPSSG
GGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFAN
RAKNIKNKPQVNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILE
SALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKILANVFLYLCAIAVGIMSYYMADRK
HRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQEL
VKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRW
QYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPAS
SKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFL
LSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDR
TRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATI
NLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKER
VYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRV
ITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KIF3C_ENST00000264712_chr2_26203242_-_ADCY3_ENST00000260600_chr2_25095588_-_4305nt
ATGGCCAGTAAGACCAAGGCCAGCGAGGCCCTCAAGGTGGTGGCCCGGTGCCGCCCCCTCAGCAGGAAGGAGGAGGCTGCTGGTCACGAG
CAGATCCTGACCATGGACGTGAAACTGGGCCAGGTGACCCTGCGGAACCCCCGCGCCGCCCCGGGGGAGCTGCCCAAGACCTTCACCTTT
GACGCCGTGTATGATGCCAGCTCCAAGCAGGCCGACCTGTATGACGAAACCGTGAGGCCCCTGATAGACTCCGTGCTCCAGGGTTTCAAT
GGCACGGTGTTTGCCTATGGCCAGACGGGCACTGGCAAGACCTATACCATGCAGGGGACCTGGGTGGAGCCCGAGCTGCGCGGGGTCATC
CCGAATGCCTTTGAGCACATCTTCACCCACATCTCCCGCTCCCAGAACCAACAGTACCTGGTCCGGGCCTCCTATTTGGAGATCTACCAG
GAAGAGATTCGAGACCTGCTCTCCAAGGAGCCGGGCAAGAGGCTAGAGCTGAAAGAGAACCCCGAGACTGGCGTCTACATCAAGGACCTC
TCCTCCTTCGTCACCAAGAATGTCAAGGAGATTGAGCATGTGATGAACCTGGGGAACCAGACCCGGGCTGTGGGCAGCACCCACATGAAT
GAGGTCAGCTCCCGCTCCCATGCCATCTTCATCATCACTGTGGAGTGCAGCGAACGTGGCTCTGATGGCCAGGACCACATCCGAGTGGGC
AAGCTCAACCTCGTGGACCTGGCTGGCAGCGAGAGGCAGAACAAGGCAGGCCCCAACACAGCGGGAGGGGCAGCCACACCATCCTCGGGT
GGCGGTGGTGGCGGTGGAGGCAGTGGTGGTGGTGCTGGTGGAGAGAGGCCTAAGGAAGCCTCCAAAATCAACCTCTCATTATCTGCCCTG
GGCAACGTGATTGCTGCCCTGGCGGGCAACAGGAGCACCCACATTCCCTACCGGGACTCCAAGCTGACCCGGCTGCTCCAGGACTCCCTG
GGGGGGAATGCCAAGACCATCATGGTAGCCACACTGGGGCCAGCTTCTCACAGCTACGATGAGAGCCTCTCCACCTTGCGCTTTGCCAAC
CGAGCCAAGAACATCAAGAACAAGCCCCAGGTGAACGAGGACCCCAAGGACACACTGCTGCGGGAATTCCAAGAGGAGATTGCCCGCCTG
AAGGCCCAGCTGGAGAAGAGGGGGATGCTGGGGAAGCGGCCCCGGAGGAAGAGCAGCCGCAGGAAGAAGGCCGTGTCCGCCCCGCCTGGG
TACCCTGAGGGCCCAGTGATTGAGGCCTGGGTGGCAGAAGAGGAGGATGACAACAACAACAACCACCGCCCGCCCCAGCCCATCCTGGAG
TCAGCCTTGGAGAAGAACATGGAGAATTACCTGCAGGAACAGAAGGAGCGGCTGGAGGAGGAGAAGGCAGCCATCCAGGATGACCGCAGC
CTGGTGAGCGAGGAGAAGCAGAAGCTGCTGGAGGAGAAGGAGAAGATGCTGGAGGACCTGCGGCGGGAACAGCAGGCCACAGAGCTGCTT
GCGGCCAAGTACAAGATCCTGGCCAACGTCTTCCTCTACCTGTGCGCCATCGCTGTGGGCATCATGTCCTACTACATGGCTGACCGCAAG
CACCGCAAGGCCTTCCTGGAGGCCCGCCAGTCGCTGGAGGTGAAGATGAACCTGGAAGAGCAGAGCCAGCAGCAGGAGAACCTCATGCTT
TCCATCCTGCCCAAGCACGTGGCTGACGAGATGCTGAAAGACATGAAGAAAGACGAGAGCCAGAAGGACCAGCAGCAGTTCAACACCATG
TACATGTACCGTCACGAGAACGTCAGCATCCTCTTTGCCGACATCGTGGGCTTTACCCAGCTGTCTTCTGCCTGCAGTGCCCAGGAGCTT
GTGAAGCTGCTCAACGAGCTCTTTGCCCGCTTTGACAAGCTGGCAGCTAAATACCACCAGCTGCGGATTAAGATCCTGGGCGACTGCTAC
TACTGCATCTGCGGCTTGCCCGACTACCGGGAGGACCACGCCGTCTGCTCCATCCTCATGGGGCTGGCCATGGTGGAGGCCATCTCGTAT
GTGCGGGAGAAGACCAAGACTGGGGTGGACATGCGTGTGGGGGTGCACACGGGCACCGTGCTGGGGGGCGTCCTGGGCCAGAAGCGCTGG
CAGTACGACGTGTGGTCGACTGATGTCACTGTAGCCAACAAGATGGAGGCCGGCGGCATCCCTGGGCGCGTGCACATCTCCCAGAGCACC
ATGGACTGCCTGAAAGGGGAGTTTGATGTGGAGCCAGGCGATGGGGGCAGCCGCTGTGATTACCTAGAAGAGAAGGGTATTGAAACCTAC
CTCATCATTGCCTCCAAGCCAGAGGTGAAGAAAACAGCCACCCAGAATGGCCTCAATGGCTCGGCCCTGCCCAATGGAGCACCAGCTTCC
TCAAAGTCCAGCTCCCCTGCCCTCATTGAGACCAAGGAGCCCAACGGGAGTGCCCACAGCAGTGGGTCCACGTCGGAGAAGCCCGAGGAG
CAGGATGCCCAGGCCGACAACCCCTCATTCCCCAACCCACGCCGGAGGCTGCGCCTGCAGGACCTGGCTGACCGAGTGGTGGATGCCTCT
GAAGATGAGCACGAGCTCAACCAGCTGCTCAACGAGGCCCTGCTTGAGCGAGAGTCCGCCCAAGTAGTAAAGAAGAGAAACACCTTCCTC
TTGTCCATGCGGTTCATGGACCCCGAGATGGAAACCCGCTACTCGGTGGAGAAGGAGAAGCAGAGTGGGGCTGCCTTCAGCTGCTCCTGC
GTCGTCCTGCTCTGCACGGCCCTGGTCGAGATACTCATCGACCCCTGGCTAATGACAAACTATGTGACCTTCATGGTGGGGGAGATTCTG
CTCCTCATCCTGACCATCTGCTCCCTGGCTGCCATCTTTCCCCGGGCCTTTCCTAAGAAGCTTGTGGCCTTCTCAACTTGGATTGACCGG
ACCCGCTGGGCCAGGAACACCTGGGCCATGCTCGCCATCTTCATCCTGGTGATGGCAAATGTCGTGGACATGCTCAGCTGTCTCCAGTAC
TACACGGGACCCAGCAATGCAACGGCAGGGATGGAAACGGAGGGCAGCTGCCTGGAGAACCCCAAGTATTACAACTATGTGGCCGTGCTG
TCCCTCATCGCCACCATCATGCTGGTGCAGGTCAGCCACATGGTGAAGCTCACGCTCATGCTGCTCGTCGCAGGCGCCGTGGCCACCATC
AACCTCTATGCCTGGCGTCCCGTCTTTGATGAATACGACCACAAGCGTTTTCGGGAGCACGACTTACCTATGGTGGCCTTAGAGCAGATG
CAAGGATTCAACCCTGGGCTCAATGGCACTGACAGGCTGCCCCTGGTGCCTTCCAAGTACTCTATGACGGTGATGGTGTTCCTCATGATG
CTCAGCTTCTACTACTTCTCCCGCCACGTAGAAAAACTGGCACGGACACTTTTCTTGTGGAAGATTGAGGTCCACGACCAGAAGGAACGT
GTCTATGAGATGCGACGCTGGAACGAGGCCTTGGTCACCAACATGTTGCCTGAGCACGTGGCACGCCATTTCCTGGGGTCCAAGAAGAGA
GATGAGGAGCTGTATAGCCAGACGTATGATGAGATTGGAGTCATGTTTGCCTCCCTGCCCAACTTTGCTGACTTCTACACAGAGGAGAGC
ATCAACAATGGTGGTATTGAGTGTCTGCGTTTCCTCAATGAAATCATCTCAGATTTTGACTCTCTCCTGGACAATCCCAAGTTCCGGGTG
ATCACCAAGATCAAAACCATTGGCAGCACGTATATGGCGGCTTCAGGAGTCACCCCCGATGTCAACACCAATGGCTTTGCCAGCTCCAAC
AAGGAAGACAAGTCCGAGAGAGAGCGCTGGCAGCACCTGGCTGACCTGGCCGACTTCGCGCTGGCCATGAAGGATACGCTCACCAACATC
AACAACCAGTCCTTCAATAACTTCATGCTGCGCATAGGCATGAACAAAGGCGGGGTTCTGGCTGGGGTCATCGGAGCCCGGAAACCACAC
TACGACATCTGGGGCAATACAGTCAATGTAGCCAGCAGGATGGAGTCCACGGGGGTCATGGGCAACATTCAGGTGGTAGAAGAAACCCAA
GTCATCCTCCGAGAGTACGGCTTCCGCTTTGTGAGGCGAGGCCCCATCTTTGTGAAGGGGAAGGGGGAGCTGCTGACCTTCTTCTTGAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_KIF3C_ENST00000264712_chr2_26203242_-_ADCY3_ENST00000260600_chr2_25095588_-_5648nt
GTTTTTCTCTCTCATTCTCCAGTGGCGGCGGCGGGGAAGGCGGAGGCAGAGGCAGCAGCAGCCGCGCTGGCTGCAATGAATGATCCCCCA
GCTTGGGGGGAGGACTCCAGGTGAGCCTCTGCCCTCGGGAGGCCCGGGACCCCCGGCCGCCCACGACCGGCAGCCCACGCTATGGATCCC
TAGAGGAAGGAGGAGAAGACAGCTCGCCGCCCACCCCCATCCCATTTTCCTCTTCCTTTATCTCATTGTTGCCGAAGCTGTTTACGGCAG
CGCTCCCTCTGCTCCTGCATGGGGCGGGCTCCGGGCACGGCTGCTCGGCAGGCGCTGCTCCCGCGGCGACTGGGGGATTCTGCCTAATTC
ACCTCCCAGCCGGTGCAGAGAGGACCGGAGAGCGGTGGAGGCCCGGACTGCAGCAGCGTTGGGGCCACCTCCCAGCGTCCCCACCCTAGG
AGGCTGCATGCGGATTGAAGAGCTGCGCCTGGGGGCTGGGCCGGCCCCGCTGATCCCGACCTAGCGAGCAGGATAGCAGGACCGCCCAGG
CTGCGGAGGGGCTCGGGGGCAGGAAGGTCAGAGCAGCAAGATGGCCAGTAAGACCAAGGCCAGCGAGGCCCTCAAGGTGGTGGCCCGGTG
CCGCCCCCTCAGCAGGAAGGAGGAGGCTGCTGGTCACGAGCAGATCCTGACCATGGACGTGAAACTGGGCCAGGTGACCCTGCGGAACCC
CCGCGCCGCCCCGGGGGAGCTGCCCAAGACCTTCACCTTTGACGCCGTGTATGATGCCAGCTCCAAGCAGGCCGACCTGTATGACGAAAC
CGTGAGGCCCCTGATAGACTCCGTGCTCCAGGGTTTCAATGGCACGGTGTTTGCCTATGGCCAGACGGGCACTGGCAAGACCTATACCAT
GCAGGGGACCTGGGTGGAGCCCGAGCTGCGCGGGGTCATCCCGAATGCCTTTGAGCACATCTTCACCCACATCTCCCGCTCCCAGAACCA
ACAGTACCTGGTCCGGGCCTCCTATTTGGAGATCTACCAGGAAGAGATTCGAGACCTGCTCTCCAAGGAGCCGGGCAAGAGGCTAGAGCT
GAAAGAGAACCCCGAGACTGGCGTCTACATCAAGGACCTCTCCTCCTTCGTCACCAAGAATGTCAAGGAGATTGAGCATGTGATGAACCT
GGGGAACCAGACCCGGGCTGTGGGCAGCACCCACATGAATGAGGTCAGCTCCCGCTCCCATGCCATCTTCATCATCACTGTGGAGTGCAG
CGAACGTGGCTCTGATGGCCAGGACCACATCCGAGTGGGCAAGCTCAACCTCGTGGACCTGGCTGGCAGCGAGAGGCAGAACAAGGCAGG
CCCCAACACAGCGGGAGGGGCAGCCACACCATCCTCGGGTGGCGGTGGTGGCGGTGGAGGCAGTGGTGGTGGTGCTGGTGGAGAGAGGCC
TAAGGAAGCCTCCAAAATCAACCTCTCATTATCTGCCCTGGGCAACGTGATTGCTGCCCTGGCGGGCAACAGGAGCACCCACATTCCCTA
CCGGGACTCCAAGCTGACCCGGCTGCTCCAGGACTCCCTGGGGGGGAATGCCAAGACCATCATGGTAGCCACACTGGGGCCAGCTTCTCA
CAGCTACGATGAGAGCCTCTCCACCTTGCGCTTTGCCAACCGAGCCAAGAACATCAAGAACAAGCCCCAGGTGAACGAGGACCCCAAGGA
CACACTGCTGCGGGAATTCCAAGAGGAGATTGCCCGCCTGAAGGCCCAGCTGGAGAAGAGGGGGATGCTGGGGAAGCGGCCCCGGAGGAA
GAGCAGCCGCAGGAAGAAGGCCGTGTCCGCCCCGCCTGGGTACCCTGAGGGCCCAGTGATTGAGGCCTGGGTGGCAGAAGAGGAGGATGA
CAACAACAACAACCACCGCCCGCCCCAGCCCATCCTGGAGTCAGCCTTGGAGAAGAACATGGAGAATTACCTGCAGGAACAGAAGGAGCG
GCTGGAGGAGGAGAAGGCAGCCATCCAGGATGACCGCAGCCTGGTGAGCGAGGAGAAGCAGAAGCTGCTGGAGGAGAAGGAGAAGATGCT
GGAGGACCTGCGGCGGGAACAGCAGGCCACAGAGCTGCTTGCGGCCAAGTACAAGATCCTGGCCAACGTCTTCCTCTACCTGTGCGCCAT
CGCTGTGGGCATCATGTCCTACTACATGGCTGACCGCAAGCACCGCAAGGCCTTCCTGGAGGCCCGCCAGTCGCTGGAGGTGAAGATGAA
CCTGGAAGAGCAGAGCCAGCAGCAGGAGAACCTCATGCTTTCCATCCTGCCCAAGCACGTGGCTGACGAGATGCTGAAAGACATGAAGAA
AGACGAGAGCCAGAAGGACCAGCAGCAGTTCAACACCATGTACATGTACCGTCACGAGAACGTCAGCATCCTCTTTGCCGACATCGTGGG
CTTTACCCAGCTGTCTTCTGCCTGCAGTGCCCAGGAGCTTGTGAAGCTGCTCAACGAGCTCTTTGCCCGCTTTGACAAGCTGGCAGCTAA
ATACCACCAGCTGCGGATTAAGATCCTGGGCGACTGCTACTACTGCATCTGCGGCTTGCCCGACTACCGGGAGGACCACGCCGTCTGCTC
CATCCTCATGGGGCTGGCCATGGTGGAGGCCATCTCGTATGTGCGGGAGAAGACCAAGACTGGGGTGGACATGCGTGTGGGGGTGCACAC
GGGCACCGTGCTGGGGGGCGTCCTGGGCCAGAAGCGCTGGCAGTACGACGTGTGGTCGACTGATGTCACTGTAGCCAACAAGATGGAGGC
CGGCGGCATCCCTGGGCGCGTGCACATCTCCCAGAGCACCATGGACTGCCTGAAAGGGGAGTTTGATGTGGAGCCAGGCGATGGGGGCAG
CCGCTGTGATTACCTAGAAGAGAAGGGTATTGAAACCTACCTCATCATTGCCTCCAAGCCAGAGGTGAAGAAAACAGCCACCCAGAATGG
CCTCAATGGCTCGGCCCTGCCCAATGGAGCACCAGCTTCCTCAAAGTCCAGCTCCCCTGCCCTCATTGAGACCAAGGAGCCCAACGGGAG
TGCCCACAGCAGTGGGTCCACGTCGGAGAAGCCCGAGGAGCAGGATGCCCAGGCCGACAACCCCTCATTCCCCAACCCACGCCGGAGGCT
GCGCCTGCAGGACCTGGCTGACCGAGTGGTGGATGCCTCTGAAGATGAGCACGAGCTCAACCAGCTGCTCAACGAGGCCCTGCTTGAGCG
AGAGTCCGCCCAAGTAGTAAAGAAGAGAAACACCTTCCTCTTGTCCATGCGGTTCATGGACCCCGAGATGGAAACCCGCTACTCGGTGGA
GAAGGAGAAGCAGAGTGGGGCTGCCTTCAGCTGCTCCTGCGTCGTCCTGCTCTGCACGGCCCTGGTCGAGATACTCATCGACCCCTGGCT
AATGACAAACTATGTGACCTTCATGGTGGGGGAGATTCTGCTCCTCATCCTGACCATCTGCTCCCTGGCTGCCATCTTTCCCCGGGCCTT
TCCTAAGAAGCTTGTGGCCTTCTCAACTTGGATTGACCGGACCCGCTGGGCCAGGAACACCTGGGCCATGCTCGCCATCTTCATCCTGGT
GATGGCAAATGTCGTGGACATGCTCAGCTGTCTCCAGTACTACACGGGACCCAGCAATGCAACGGCAGGGATGGAAACGGAGGGCAGCTG
CCTGGAGAACCCCAAGTATTACAACTATGTGGCCGTGCTGTCCCTCATCGCCACCATCATGCTGGTGCAGGTCAGCCACATGGTGAAGCT
CACGCTCATGCTGCTCGTCGCAGGCGCCGTGGCCACCATCAACCTCTATGCCTGGCGTCCCGTCTTTGATGAATACGACCACAAGCGTTT
TCGGGAGCACGACTTACCTATGGTGGCCTTAGAGCAGATGCAAGGATTCAACCCTGGGCTCAATGGCACTGACAGGCTGCCCCTGGTGCC
TTCCAAGTACTCTATGACGGTGATGGTGTTCCTCATGATGCTCAGCTTCTACTACTTCTCCCGCCACGTAGAAAAACTGGCACGGACACT
TTTCTTGTGGAAGATTGAGGTCCACGACCAGAAGGAACGTGTCTATGAGATGCGACGCTGGAACGAGGCCTTGGTCACCAACATGTTGCC
TGAGCACGTGGCACGCCATTTCCTGGGGTCCAAGAAGAGAGATGAGGAGCTGTATAGCCAGACGTATGATGAGATTGGAGTCATGTTTGC
CTCCCTGCCCAACTTTGCTGACTTCTACACAGAGGAGAGCATCAACAATGGTGGTATTGAGTGTCTGCGTTTCCTCAATGAAATCATCTC
AGATTTTGACTCTCTCCTGGACAATCCCAAGTTCCGGGTGATCACCAAGATCAAAACCATTGGCAGCACGTATATGGCGGCTTCAGGAGT
CACCCCCGATGTCAACACCAATGGCTTTGCCAGCTCCAACAAGGAAGACAAGTCCGAGAGAGAGCGCTGGCAGCACCTGGCTGACCTGGC
CGACTTCGCGCTGGCCATGAAGGATACGCTCACCAACATCAACAACCAGTCCTTCAATAACTTCATGCTGCGCATAGGCATGAACAAAGG
CGGGGTTCTGGCTGGGGTCATCGGAGCCCGGAAACCACACTACGACATCTGGGGCAATACAGTCAATGTAGCCAGCAGGATGGAGTCCAC
GGGGGTCATGGGCAACATTCAGGTGGTAGAAGAAACCCAAGTCATCCTCCGAGAGTACGGCTTCCGCTTTGTGAGGCGAGGCCCCATCTT
TGTGAAGGGGAAGGGGGAGCTGCTGACCTTCTTCTTGAAGGGGCGGGATAAGCTAGCCACCTTCCCCAATGGCCCCTCTGTCACACTGCC
CCACCAGGTGGTGGACAACTCCTGAATGGCCTCGAGCCTGCAACAGTCCAAACCGGAAGGGAGAATTTATTTTTTGAAACTGAAGGAAGT
CCCGACCTTCCTGGATTGAAGTGCACACTCATGGACTTTAGGTTTAGAAACCTCCTCAGCCTTCATTTGTTCGTGGATGTGTGAGCTCTG
AGGGTGGCCCTGCTATTCCTGTGTGTGCCTGTAGTGTCCCCAGCATAGGGGTCTTAGGCATAGGGCTGAACAGTCCTTCCAGAGCCCTCG
TTCCAATCCCTGCCGTCCTTGCCCCTGAGGGGCCCTGACCACTGTGAGCAGGAGGGTGGCAGAGCTGGGACAAAGCTGCCTTTGCCGCTG
GGCTTTCCGGGACTGTGGAGGGAGCACAGGCGGGGAAGCTCCACTTCAGACAGGGCTTGGTGGGGCAGGACATGGCTCCCATTTTGAAGG
GAGGTCTCCATGTGGTCCGAGTGAGGTGAGACGGCCCTCGTCCTGGTGTTCCTGATCATCTTGAAAGGTTCTTCTGGAACTCCTGTCCCC
TTAGTCATGAGAACAGAAAGTGCAATATTTCCTTTCACCTGGCAGGGGAGGGGGGATTTATTTCTGAAAGAAAAATATATAAACAGATCT
TCTACATTTATATTTTTAATCTTCTGTTAAATACACTTTCCGATATTGCCTTGCCTTTTGAGCTCTTGCTACAGTCGCCTTTGCTACTGC


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FusionGenePPI for KIF3C_ADCY3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF3CCDC5L, DISC1, KIF3A, KIFAP3, ZC3H3, KIAA1279, AKAP12, STK4, DYRK2, SAV1, KIF3BADCY3ADRB2, POPDC2, LGALS3, ANKMY2, SLC4A8, ASIC4, CNGA3, IL17RC, PCDHGA5, CD79B, IZUMO1, SLC17A2, KCNA5, MTNR1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF3C_ADCY3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF3C_ADCY3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF3CC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneADCY3C0005586Bipolar Disorder1PSYGENET
TgeneADCY3C0011875Diabetic Angiopathies1CTD_human
TgeneADCY3C0525045Mood Disorders1PSYGENET