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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18892

FusionGeneSummary for KIF3B_KIF3B

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF3B_KIF3B
Fusion gene ID: 18892
HgeneTgene
Gene symbol

KIF3B

KIF3B

Gene ID

9371

9371

Gene namekinesin family member 3Bkinesin family member 3B
SynonymsFLA8|HH0048|KLP-11FLA8|HH0048|KLP-11
Cytomap

20q11.21

20q11.21

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF3Bmicrotubule plus end-directed kinesin motor 3Bkinesin-like protein KIF3Bmicrotubule plus end-directed kinesin motor 3B
Modification date2018052320180523
UniProtAcc

O15066

O15066

Ensembl transtripts involved in fusion geneENST00000375712, ENST00000418717, 
ENST00000375712, ENST00000418717, 
Fusion gene scores* DoF score8 X 6 X 6=2883 X 3 X 1=9
# samples 88
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/9*10)=3.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIF3B [Title/Abstract] AND KIF3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA740234KIF3Bchr20

30922791

+KIF3Bchr20

30922726

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000375712ENST00000375712KIF3Bchr20

30922791

+KIF3Bchr20

30922726

-
3UTR-intronENST00000375712ENST00000418717KIF3Bchr20

30922791

+KIF3Bchr20

30922726

-
intron-3UTRENST00000418717ENST00000375712KIF3Bchr20

30922791

+KIF3Bchr20

30922726

-
intron-intronENST00000418717ENST00000418717KIF3Bchr20

30922791

+KIF3Bchr20

30922726

-

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FusionProtFeatures for KIF3B_KIF3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF3B

O15066

KIF3B

O15066

Involved in tethering the chromosomes to the spindlepole and in chromosome movement. Microtubule-based anterogradetranslocator for membranous organelles. Plus end-directedmicrotubule sliding activity in vitro (By similarity).{ECO:0000250}. Involved in tethering the chromosomes to the spindlepole and in chromosome movement. Microtubule-based anterogradetranslocator for membranous organelles. Plus end-directedmicrotubule sliding activity in vitro (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIF3B_KIF3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIF3B_KIF3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF3B_KIF3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF3B_KIF3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource