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Fusion gene ID: 18887 |
FusionGeneSummary for KIF2C_CHTF8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIF2C_CHTF8 | Fusion gene ID: 18887 | Hgene | Tgene | Gene symbol | KIF2C | CHTF8 | Gene ID | 11004 | 54921 |
| Gene name | kinesin family member 2C | chromosome transmission fidelity factor 8 | |
| Synonyms | CT139|KNSL6|MCAK | CTF8|DERPC | |
| Cytomap | 1p34.1 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kinesin-like protein KIF2Ckinesin-like protein 6mitotic centromere-associated kinesintestis tissue sperm-binding protein Li 68n | chromosome transmission fidelity protein 8 homologCTF8, chromosome transmission fidelity factor 8 homologProtein DERPCdecreased expression in renal and prostate cancer protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q99661 | P0CG13 | |
| Ensembl transtripts involved in fusion gene | ENST00000372224, ENST00000493027, ENST00000372218, ENST00000372222, ENST00000372217, | ENST00000448552, ENST00000306585, ENST00000523421, ENST00000518041, ENST00000574807, ENST00000398235, ENST00000519520, ENST00000520529, ENST00000522091, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: KIF2C [Title/Abstract] AND CHTF8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KIF2C | GO:0007019 | microtubule depolymerization | 21820309 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CN388633 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-5UTR | ENST00000372224 | ENST00000448552 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372224 | ENST00000306585 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372224 | ENST00000523421 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-intron | ENST00000372224 | ENST00000518041 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-intron | ENST00000372224 | ENST00000574807 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-intron | ENST00000372224 | ENST00000398235 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372224 | ENST00000519520 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-intron | ENST00000372224 | ENST00000520529 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372224 | ENST00000522091 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-5UTR | ENST00000493027 | ENST00000448552 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-5UTR | ENST00000493027 | ENST00000306585 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-5UTR | ENST00000493027 | ENST00000523421 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-intron | ENST00000493027 | ENST00000518041 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-intron | ENST00000493027 | ENST00000574807 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-intron | ENST00000493027 | ENST00000398235 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-5UTR | ENST00000493027 | ENST00000519520 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-intron | ENST00000493027 | ENST00000520529 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-5UTR | ENST00000493027 | ENST00000522091 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372218 | ENST00000448552 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372218 | ENST00000306585 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372218 | ENST00000523421 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-intron | ENST00000372218 | ENST00000518041 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-intron | ENST00000372218 | ENST00000574807 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-intron | ENST00000372218 | ENST00000398235 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372218 | ENST00000519520 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-intron | ENST00000372218 | ENST00000520529 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372218 | ENST00000522091 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-5UTR | ENST00000372222 | ENST00000448552 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-5UTR | ENST00000372222 | ENST00000306585 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-5UTR | ENST00000372222 | ENST00000523421 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-intron | ENST00000372222 | ENST00000518041 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-intron | ENST00000372222 | ENST00000574807 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-intron | ENST00000372222 | ENST00000398235 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-5UTR | ENST00000372222 | ENST00000519520 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-intron | ENST00000372222 | ENST00000520529 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| intron-5UTR | ENST00000372222 | ENST00000522091 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372217 | ENST00000448552 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372217 | ENST00000306585 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372217 | ENST00000523421 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-intron | ENST00000372217 | ENST00000518041 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-intron | ENST00000372217 | ENST00000574807 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-intron | ENST00000372217 | ENST00000398235 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372217 | ENST00000519520 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-intron | ENST00000372217 | ENST00000520529 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
| 3UTR-5UTR | ENST00000372217 | ENST00000522091 | KIF2C | chr1 | 45233315 | - | CHTF8 | chr16 | 69166466 | - |
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FusionProtFeatures for KIF2C_CHTF8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIF2C | CHTF8 |
| In complex with KIF18B, constitutes the majormicrotubule plus-end depolymerizing activity in mitotic cells(PubMed:21820309). Regulates the turnover of microtubules at thekinetochore and functions in chromosome segregation during mitosis(PubMed:19060894). Plays a role in chromosome congression and isrequired for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).{ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309,ECO:0000269|PubMed:23891108}. | Chromosome cohesion factor involved in sister chromatidcohesion and fidelity of chromosome transmission. Component of oneof the cell nuclear antigen loader complexes, CTF18-replicationfactor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2,RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that isstimulated the presence of primed DNA, replication protein A (RPA)and proliferating cell nuclear antigen (PCNA). The CTF18-RFCcomplex catalyzes the ATP-dependent loading of PCNA onto primedand gapped DNA. It also interacts with and stimulates POLH, whichis suggestive of a protein network that coordinates DNA repair,recombination and chromosome cohesion reactions with replicationfork progression. {ECO:0000269|PubMed:12930902,ECO:0000269|PubMed:17545166}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KIF2C_CHTF8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KIF2C_CHTF8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIF2C_CHTF8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIF2C_CHTF8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KIF2C | C0011616 | Contact Dermatitis | 1 | CTD_human |
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