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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18881

FusionGeneSummary for KIF27_C9orf64

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF27_C9orf64
Fusion gene ID: 18881
HgeneTgene
Gene symbol

KIF27

C9orf64

Gene ID

55582

84267

Gene namekinesin family member 27chromosome 9 open reading frame 64
Synonyms--
Cytomap

9q21.32

9q21.32

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF27queuosine salvage proteinUPF0553 protein C9orf64
Modification date2018052320180523
UniProtAcc

Q86VH2

Q5T6V5

Ensembl transtripts involved in fusion geneENST00000297814, ENST00000413982, 
ENST00000334204, ENST00000376347, 
ENST00000376344, ENST00000314700, 
ENST00000376340, 
Fusion gene scores* DoF score3 X 4 X 5=602 X 2 X 2=8
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: KIF27 [Title/Abstract] AND C9orf64 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-36-1577-01AKIF27chr9

86523367

-C9orf64chr9

86570555

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000297814ENST00000376344KIF27chr9

86523367

-C9orf64chr9

86570555

-
5CDS-5UTRENST00000297814ENST00000314700KIF27chr9

86523367

-C9orf64chr9

86570555

-
5CDS-5UTRENST00000297814ENST00000376340KIF27chr9

86523367

-C9orf64chr9

86570555

-
Frame-shiftENST00000413982ENST00000376344KIF27chr9

86523367

-C9orf64chr9

86570555

-
5CDS-5UTRENST00000413982ENST00000314700KIF27chr9

86523367

-C9orf64chr9

86570555

-
5CDS-5UTRENST00000413982ENST00000376340KIF27chr9

86523367

-C9orf64chr9

86570555

-
Frame-shiftENST00000334204ENST00000376344KIF27chr9

86523367

-C9orf64chr9

86570555

-
5CDS-5UTRENST00000334204ENST00000314700KIF27chr9

86523367

-C9orf64chr9

86570555

-
5CDS-5UTRENST00000334204ENST00000376340KIF27chr9

86523367

-C9orf64chr9

86570555

-
intron-3CDSENST00000376347ENST00000376344KIF27chr9

86523367

-C9orf64chr9

86570555

-
intron-5UTRENST00000376347ENST00000314700KIF27chr9

86523367

-C9orf64chr9

86570555

-
intron-5UTRENST00000376347ENST00000376340KIF27chr9

86523367

-C9orf64chr9

86570555

-

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FusionProtFeatures for KIF27_C9orf64


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF27

Q86VH2

C9orf64

Q5T6V5

Plays an essential role in motile ciliogenesis.{ECO:0000250}. Involved in salvaging queuosine.{ECO:0000269|PubMed:15164053}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIF27_C9orf64


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIF27_C9orf64


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF27TBC1D7, STAT3, SNW1, RBM3, TESC9orf64ELAVL1, POLL, FH, CARKD, DPYD, ITPA, NEDD8, NMRAL1, PKM, NTRK1, DUSP21, DUSP28, PPIAL4G, NIF3L1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF27_C9orf64


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF27_C9orf64


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource