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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18856

FusionGeneSummary for KIF21A_CPM

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF21A_CPM
Fusion gene ID: 18856
HgeneTgene
Gene symbol

KIF21A

CPM

Gene ID

55605

1368

Gene namekinesin family member 21Acarboxypeptidase M
SynonymsCFEOM1|FEOM1|FEOM3A-
Cytomap

12q12

12q15

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF21Akinesin-like protein KIF2renal carcinoma antigen NY-REN-62carboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase B
Modification date2018052320180523
UniProtAcc

Q7Z4S6

P14384

Ensembl transtripts involved in fusion geneENST00000361961, ENST00000395670, 
ENST00000544797, ENST00000361418, 
ENST00000541463, ENST00000547745, 
ENST00000546373, ENST00000551568, 
ENST00000338356, ENST00000549691, 
Fusion gene scores* DoF score11 X 6 X 7=46238 X 10 X 8=3040
# samples 1135
** MAII scorelog2(11/462*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(35/3040*10)=-3.11864449649862
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF21A [Title/Abstract] AND CPM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTGCTTCGA-2G-AAGT-01AKIF21Achr12

39836729

-CPMchr12

69279669

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000361961ENST00000546373KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000361961ENST00000551568KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000361961ENST00000338356KIF21Achr12

39836729

-CPMchr12

69279669

-
5CDS-intronENST00000361961ENST00000549691KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000395670ENST00000546373KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000395670ENST00000551568KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000395670ENST00000338356KIF21Achr12

39836729

-CPMchr12

69279669

-
5CDS-intronENST00000395670ENST00000549691KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000544797ENST00000546373KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000544797ENST00000551568KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000544797ENST00000338356KIF21Achr12

39836729

-CPMchr12

69279669

-
5CDS-intronENST00000544797ENST00000549691KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000361418ENST00000546373KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000361418ENST00000551568KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000361418ENST00000338356KIF21Achr12

39836729

-CPMchr12

69279669

-
5CDS-intronENST00000361418ENST00000549691KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000541463ENST00000546373KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000541463ENST00000551568KIF21Achr12

39836729

-CPMchr12

69279669

-
Frame-shiftENST00000541463ENST00000338356KIF21Achr12

39836729

-CPMchr12

69279669

-
5CDS-intronENST00000541463ENST00000549691KIF21Achr12

39836729

-CPMchr12

69279669

-
intron-3CDSENST00000547745ENST00000546373KIF21Achr12

39836729

-CPMchr12

69279669

-
intron-3CDSENST00000547745ENST00000551568KIF21Achr12

39836729

-CPMchr12

69279669

-
intron-3CDSENST00000547745ENST00000338356KIF21Achr12

39836729

-CPMchr12

69279669

-
intron-intronENST00000547745ENST00000549691KIF21Achr12

39836729

-CPMchr12

69279669

-

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FusionProtFeatures for KIF21A_CPM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF21A

Q7Z4S6

CPM

P14384

Specifically removes C-terminal basic residues (Arg orLys) from peptides and proteins. It is believed to play importantroles in the control of peptide hormone and growth factor activityat the cell surface, and in the membrane-localized degradation ofextracellular proteins. {ECO:0000269|PubMed:12457462}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIF21A_CPM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIF21A_CPM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF21AELAVL1, NCS1, SRP68, SRP72, SHMT2, MOV10, NXF1, NTRK1, CCT6A, MAP3K4, NVL, PFDN1, PFDN2, RAD51, RBM4, TBX3, TCP1, CCT3, NCOA4, UBL4A, PPFIBP1, NOLC1, CCT7, CCT4, CCT2, TACC2, CCT8, RAB11FIP2, CCT5, ENDOD1, KANK1, KANK2, NOL8, PLXNA3, DYNLL1, KIF21B, PHRF1, RNF123, ZNF106, ZNF668, FIP1L1, CD99L2, MSI2, DGKH, C6orf136, TTC9C, SNW1, CDC5L, P4HA3, TRIM25CPMELAVL1, CAPZA2, DBN1, FLNA, GAK, MYH9, PPP1CC, RAB7A, PDLIM7, ATP6AP2, SYNPO, MAPRE1, GOLT1B, LIMA1, ANLN, MYO19, ZSCAN12, ULBP1, FTH1, TBC1D22B, GTPBP3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF21A_CPM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF21A_CPM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF21AC1851102Fibrosis Of Extraocular Muscles, Congenital, 14ORPHANET;UNIPROT
HgeneKIF21AC0149925Small cell carcinoma of lung1CTD_human
TgeneCPMC0014175Endometriosis1CTD_human
TgeneCPMC0037116Silicosis1CTD_human