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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18821

FusionGeneSummary for KIF18B_C1QL1

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF18B_C1QL1
Fusion gene ID: 18821
HgeneTgene
Gene symbol

KIF18B

C1QL1

Gene ID

146909

10882

Gene namekinesin family member 18Bcomplement C1q like 1
Synonyms-C1QRF|C1QTNF14|CRF
Cytomap

17q21.31

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF18BC1q-related factorC1q and tumor necrosis factor-related protein 14C1q/TNF-related protein 14complement component 1, q subcomponent-like 1
Modification date2018052320180519
UniProtAcc

Q86Y91

O75973

Ensembl transtripts involved in fusion geneENST00000587309, ENST00000438933, 
ENST00000593135, ENST00000339151, 
ENST00000590129, 
ENST00000253407, 
Fusion gene scores* DoF score4 X 3 X 4=483 X 2 X 3=18
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIF18B [Title/Abstract] AND C1QL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIF18B

GO:0000278

mitotic cell cycle

20600703

HgeneKIF18B

GO:0007019

microtubule depolymerization

21820309

HgeneKIF18B

GO:0051302

regulation of cell division

20600703


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-OR-A5LD-01AKIF18Bchr17

43024996

-C1QL1chr17

43037735

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000587309ENST00000253407KIF18Bchr17

43024996

-C1QL1chr17

43037735

-
intron-3CDSENST00000438933ENST00000253407KIF18Bchr17

43024996

-C1QL1chr17

43037735

-
5UTR-3CDSENST00000593135ENST00000253407KIF18Bchr17

43024996

-C1QL1chr17

43037735

-
5UTR-3CDSENST00000339151ENST00000253407KIF18Bchr17

43024996

-C1QL1chr17

43037735

-
intron-3CDSENST00000590129ENST00000253407KIF18Bchr17

43024996

-C1QL1chr17

43037735

-

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FusionProtFeatures for KIF18B_C1QL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF18B

Q86Y91

C1QL1

O75973

In complex with KIF2C, constitutes the major microtubuleplus-end depolymerizing activity in mitotic cells. Its major rolemay be to transport KIF2C and/or MAPRE1 along microtubules.{ECO:0000269|PubMed:20600703, ECO:0000269|PubMed:21820309}. May regulate the number of excitatory synapses that areformed on hippocampus neurons. Has no effect on inhibitorysynapses (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIF18B_C1QL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIF18B_C1QL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF18BMOV10, NXF1, MAPRE1, NUP50, HIST1H2BG, HIST1H3A, PPP1CB, LTN1, KIAA1279, TXLNB, PLOD1, P4HA2, AHCYL2, KIF2B, NELL2, MAPRE3, KIF2CC1QL1ELAVL1, NOTCH3, ICAM2, C1QTNF9, ZACN, COL10A1, CD1E, TMEM30B, HTR3A, CBLN4, PNLDC1, TMED6, P2RX2, FUT3, YKT6, DEFA5, F7, MSRB3, NCEH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF18B_C1QL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF18B_C1QL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource