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Fusion gene ID: 18811 |
FusionGeneSummary for KIF14_DDX59 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIF14_DDX59 | Fusion gene ID: 18811 | Hgene | Tgene | Gene symbol | KIF14 | DDX59 | Gene ID | 9928 | 83479 |
| Gene name | kinesin family member 14 | DEAD-box helicase 59 | |
| Synonyms | MCPH20|MKS12 | OFD5|ZNHIT5 | |
| Cytomap | 1q32.1 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kinesin-like protein KIF14 | probable ATP-dependent RNA helicase DDX59DEAD (Asp-Glu-Ala-Asp) box polypeptide 59DEAD box protein 59zinc finger HIT domain-containing protein 5 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q15058 | Q5T1V6 | |
| Ensembl transtripts involved in fusion gene | ENST00000367350, | ENST00000447706, ENST00000367348, ENST00000331314, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: KIF14 [Title/Abstract] AND DDX59 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KIF14 | GO:0008284 | positive regulation of cell proliferation | 24784001 |
| Hgene | KIF14 | GO:0034446 | substrate adhesion-dependent cell spreading | 23209302 |
| Hgene | KIF14 | GO:0045184 | establishment of protein localization | 23209302 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-77-8153-01A | KIF14 | chr1 | 200584483 | - | DDX59 | chr1 | 200613645 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000367350 | ENST00000447706 | KIF14 | chr1 | 200584483 | - | DDX59 | chr1 | 200613645 | - |
| 5CDS-intron | ENST00000367350 | ENST00000367348 | KIF14 | chr1 | 200584483 | - | DDX59 | chr1 | 200613645 | - |
| 5CDS-intron | ENST00000367350 | ENST00000331314 | KIF14 | chr1 | 200584483 | - | DDX59 | chr1 | 200613645 | - |
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FusionProtFeatures for KIF14_DDX59 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIF14 | DDX59 |
| Microtubule motor protein that binds to microtubuleswith high affinity through each tubulin heterodimer and has anATPase activity (By similarity). Plays a role in many processeslike cell division, cytokinesis and also in cell proliferation andapoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis,targets to central spindle and midbody through its interactionwith PRC1 and CIT respectively (PubMed:16431929). Regulates cellgrowth through regulation of cell cycle progression andcytokinesis (PubMed:24854087). During cell cycle progression actsthrough SCF-dependent proteasomal ubiquitin-dependent proteincatabolic process which controls CDKN1B degradation, resulting inpositive regulation of cyclins, including CCNE1, CCND1 and CCNB1(PubMed:24854087). During late neurogenesis, regulates thecerebellar, cerebral cortex and olfactory bulb development throughregulation of apoptosis, cell proliferation and cell division (Bysimilarity). Also is required for chromosome congression andalignment during mitotic cell cycle process (PubMed:15843429).Regulates cell spreading, focal adhesion dynamics, and cellmigration through its interaction with RADIL resulting inregulation of RAP1A-mediated inside-out integrin activation bytethering RADIL on microtubules (PubMed:23209302).{ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429,ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480,ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001,ECO:0000269|PubMed:24854087}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KIF14_DDX59 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KIF14_DDX59 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KIF14 | SVIL, SIRT7, TJP2, ZBTB1, OBSL1, SPINT2, EFNB2, SCGN, CD274, VSIG2, CA14, CD68, PNKD, NTRK1, CENPJ, MED4, CLK1, PCM1, CEP104, CEP162, CEP290, CEP120, CEP152, CNTROB, SPICE1, CEP128, CEP135, CEP63, CEP89, CNTRL, NINL, NIN, ODF2, RPGRIP1L, DCTN1, LCA5, RPGRIP1, ATP5I, URB1, TSNAX, CCDC14, TUBA1C, KLC4, HNRNPA1L2, KIAA1279, TMCO1, MCM2, EYA2, TEX28, CCDC89, EPHA1, GORASP2, SIGLECL1, CLMP, FCGRT, TMEM206, TNFRSF1A, PTPRN, TUBGCP2, TUBG1 | DDX59 | MOV10, NXF1, HIST1H2BG, DDX59, HSP90AA1, HSP90AB1, HSPA8, STIP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIF14_DDX59 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIF14_DDX59 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DDX59 | C1868118 | Orofaciodigital syndrome 5 | 1 | ORPHANET;UNIPROT |
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