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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18798

FusionGeneSummary for KIF13B_EPN2

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF13B_EPN2
Fusion gene ID: 18798
HgeneTgene
Gene symbol

KIF13B

EPN2

Gene ID

23303

22905

Gene namekinesin family member 13Bepsin 2
SynonymsGAKINEHB21
Cytomap

8p12

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF13Bguanylate kinase associated kinesinkinesin 13Bkinesin-like protein GAKINepsin-2EPS-15-interacting protein 2Eps15 binding protein
Modification date2018052320180522
UniProtAcc

Q9NQT8

O95208

Ensembl transtripts involved in fusion geneENST00000524189, ENST00000521515, 
ENST00000404075, 		ENST00000441293, 
ENST00000314728, ENST00000347697, 
ENST00000395618, ENST00000575595, 
ENST00000395620, ENST00000395626, 
ENST00000571254, 
Fusion gene scores* DoF score17 X 14 X 11=26189 X 9 X 5=405
# samples 1710
** MAII scorelog2(17/2618*10)=-3.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF13B [Title/Abstract] AND EPN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIF13B

GO:0050770

regulation of axonogenesis

20194617


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-B6-A0WV-01AKIF13Bchr8

29102863

-EPN2chr17

19185268

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000524189ENST00000441293KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-5UTRENST00000524189ENST00000314728KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-5UTRENST00000524189ENST00000347697KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000395618KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000575595KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000395620KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000395626KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000571254KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000441293KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-5UTRENST00000521515ENST00000314728KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-5UTRENST00000521515ENST00000347697KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000395618KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000575595KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000395620KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000395626KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000571254KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000441293KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-5UTRENST00000404075ENST00000314728KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-5UTRENST00000404075ENST00000347697KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000395618KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000575595KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000395620KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000395626KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000571254KIF13Bchr8

29102863

-EPN2chr17

19185268

+

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FusionProtFeatures for KIF13B_EPN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF13B

Q9NQT8

EPN2

O95208

Involved in reorganization of the cortical cytoskeleton.Regulates axon formation by promoting the formation of extraaxons. May be functionally important for the intracellulartrafficking of MAGUKs and associated protein complexes.{ECO:0000269|PubMed:20194617}. Plays a role in the formation of clathrin-coatedinvaginations and endocytosis. {ECO:0000269|PubMed:10567358}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIF13B_EPN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIF13B_EPN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF13BDLG1, DLG4, MARK2, TERF2, BCL6, CUL3, PPP1CA, YWHAB, NTRK1, MYH9, ASB7, KIAA1279, ARF6, KCTD3, ZBTB21, KSR1, CGN, GIGYF1, LRFN1, RTKN, DENND1A, DENND4C, MAST3, SH3PXD2A, SRGAP2, LPIN3, EIF4E2, SIPA1L1, PPM1H, LIMA1, MAGI1, TESK2, DCLK1, SH3RF3, ZNF638, NF1, CBY1, MAPKAP1, HDAC4, CDC25C, TANC2, PTPN13, RALGPS2, GIGYF2, NADK, SRSF12, CAMSAP2, SYDE1, AGAP1, CDC25B, CDK16, RASAL2, KIAA1804, TIAM1, OSBPL6, FAM110B, PHLDB2, RPTOR, USP21, PLEKHA7, FAM53C, ANKRD34A, KIF1C, DENND4A, NAV1, MELK, GAB2, CWC25, STARD13, INPP5E, PTPN14, FAM110A, MTFR1L, HDAC7, CSNK1A1, DEPDC1B, HDAC5, LARP1, RAB11FIP2, MICALL1, DACT3, TBC1D1, PLEKHA5, CHEK1, KIF1B, CRTC3, FGD6, MLLT4, PANK2, REEP3, EDC3, CRTC2, WEE1, DCP1A, DCP1B, BAIAP2, TBC1D25, CRTC1, PAK4, KLC3, SH3BP4EPN2CLTC, ITSN1, UBQLN2, UBC, APOE, RALBP1, EPN3, TMEM17, GTSE1, CDH1, RAB3IP, WBP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF13B_EPN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF13B_EPN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource