FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 18792

FusionGeneSummary for KIF13A_TPMT

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF13A_TPMT
Fusion gene ID: 18792
HgeneTgene
Gene symbol

KIF13A

TPMT

Gene ID

63971

7172

Gene namekinesin family member 13Athiopurine S-methyltransferase
SynonymsRBKIN|bA500C11.2TPMTD
Cytomap

6p22.3

6p22.3

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF13Ahomolog of mouse KIF13A mannose-6-phosphate receptor transporterkinesin-like protein RBKINthiopurine S-methyltransferaseS-adenosyl-L-methionine:thiopurine S-methyltransferase
Modification date2018052320180523
UniProtAcc

Q9H1H9

P51580

Ensembl transtripts involved in fusion geneENST00000378814, ENST00000259711, 
ENST00000378843, ENST00000378826, 
ENST00000378816, ENST00000502704, 
ENST00000503342, 
ENST00000309983, 
Fusion gene scores* DoF score7 X 4 X 6=1685 X 1 X 4=20
# samples 75
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIF13A [Title/Abstract] AND TPMT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTPMT

GO:0017144

drug metabolic process

657528|18484748


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-XJ-A9DX-01AKIF13Achr6

17987285

-TPMTchr6

18149402

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000378814ENST00000309983KIF13Achr6

17987285

-TPMTchr6

18149402

-
5CDS-5UTRENST00000259711ENST00000309983KIF13Achr6

17987285

-TPMTchr6

18149402

-
5CDS-5UTRENST00000378843ENST00000309983KIF13Achr6

17987285

-TPMTchr6

18149402

-
5CDS-5UTRENST00000378826ENST00000309983KIF13Achr6

17987285

-TPMTchr6

18149402

-
5CDS-5UTRENST00000378816ENST00000309983KIF13Achr6

17987285

-TPMTchr6

18149402

-
5CDS-5UTRENST00000502704ENST00000309983KIF13Achr6

17987285

-TPMTchr6

18149402

-
intron-5UTRENST00000503342ENST00000309983KIF13Achr6

17987285

-TPMTchr6

18149402

-

Top

FusionProtFeatures for KIF13A_TPMT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF13A

Q9H1H9

TPMT

P51580


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for KIF13A_TPMT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for KIF13A_TPMT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF13AAP1B1, AP1G1, AP1M1, BCAR1, HYOU1, SMC1A, SMARCAD1, PIH1D3, AP2M1, HUWE1, KIAA1279, ASB7, TRIM25TPMTAPP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for KIF13A_TPMT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTPMTP51580DB01250OlsalazineThiopurine S-methyltransferase {ECO:0000303|PubMed:18484748}small moleculeapproved

Top

RelatedDiseases for KIF13A_TPMT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTPMTC0023530Leukopenia3CTD_human
TgeneTPMTC0027947Neutropenia1CTD_human
TgeneTPMTC2750088HEARING LOSS, CISPLATIN-INDUCED, SUSCEPTIBILITY TO1CTD_human