FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 18790

FusionGeneSummary for KIF13A_KIF13A

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF13A_KIF13A
Fusion gene ID: 18790
HgeneTgene
Gene symbol

KIF13A

KIF13A

Gene ID

63971

63971

Gene namekinesin family member 13Akinesin family member 13A
SynonymsRBKIN|bA500C11.2RBKIN|bA500C11.2
Cytomap

6p22.3

6p22.3

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF13Ahomolog of mouse KIF13A mannose-6-phosphate receptor transporterkinesin-like protein RBKINkinesin-like protein KIF13Ahomolog of mouse KIF13A mannose-6-phosphate receptor transporterkinesin-like protein RBKIN
Modification date2018052320180523
UniProtAcc

Q9H1H9

Q9H1H9

Ensembl transtripts involved in fusion geneENST00000378814, ENST00000259711, 
ENST00000378843, ENST00000378826, 
ENST00000378816, ENST00000502704, 
ENST00000503342, 		ENST00000378814, 
ENST00000259711, ENST00000378843, 
ENST00000378826, ENST00000378816, 
ENST00000502704, ENST00000503342, 
Fusion gene scores* DoF score7 X 4 X 6=1685 X 5 X 2=50
# samples 75
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: KIF13A [Title/Abstract] AND KIF13A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF357666KIF13Achr6

17831343

-KIF13Achr6

17826109

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000378814ENST00000378814KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378814ENST00000259711KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378814ENST00000378843KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378814ENST00000378826KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378814ENST00000378816KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000378814ENST00000502704KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000378814ENST00000503342KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000259711ENST00000378814KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000259711ENST00000259711KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000259711ENST00000378843KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000259711ENST00000378826KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000259711ENST00000378816KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000259711ENST00000502704KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000259711ENST00000503342KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378843ENST00000378814KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378843ENST00000259711KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378843ENST00000378843KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378843ENST00000378826KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378843ENST00000378816KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000378843ENST00000502704KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000378843ENST00000503342KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378826ENST00000378814KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378826ENST00000259711KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378826ENST00000378843KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378826ENST00000378826KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378826ENST00000378816KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000378826ENST00000502704KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000378826ENST00000503342KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378816ENST00000378814KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378816ENST00000259711KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378816ENST00000378843KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378816ENST00000378826KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000378816ENST00000378816KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000378816ENST00000502704KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000378816ENST00000503342KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000502704ENST00000378814KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000502704ENST00000259711KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000502704ENST00000378843KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000502704ENST00000378826KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000502704ENST00000378816KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000502704ENST00000502704KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000502704ENST00000503342KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000503342ENST00000378814KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000503342ENST00000259711KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000503342ENST00000378843KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000503342ENST00000378826KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-3CDSENST00000503342ENST00000378816KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000503342ENST00000502704KIF13Achr6

17831343

-KIF13Achr6

17826109

+
intron-intronENST00000503342ENST00000503342KIF13Achr6

17831343

-KIF13Achr6

17826109

+

Top

FusionProtFeatures for KIF13A_KIF13A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF13A

Q9H1H9

KIF13A

Q9H1H9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for KIF13A_KIF13A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for KIF13A_KIF13A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for KIF13A_KIF13A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for KIF13A_KIF13A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource