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Fusion gene ID: 18783 |
FusionGeneSummary for KIF11_FFAR4 |
Fusion gene summary |
Fusion gene information | Fusion gene name: KIF11_FFAR4 | Fusion gene ID: 18783 | Hgene | Tgene | Gene symbol | KIF11 | FFAR4 | Gene ID | 3832 | 338557 |
Gene name | kinesin family member 11 | free fatty acid receptor 4 | |
Synonyms | EG5|HKSP|KNSL1|MCLMR|TRIP5 | BMIQ10|GPR120|GPR129|GT01|O3FAR1|PGR4 | |
Cytomap | 10q23.33 | 10q23.33 | |
Type of gene | protein-coding | protein-coding | |
Description | kinesin-like protein KIF11TR-interacting protein 5TRIP-5kinesin-like protein 1kinesin-like spindle protein HKSPkinesin-related motor protein Eg5thyroid receptor-interacting protein 5 | free fatty acid receptor 4G-protein coupled receptor 120G-protein coupled receptor 129G-protein coupled receptor GT01G-protein coupled receptor PGR4omega-3 fatty acid receptor 1 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P52732 | Q5NUL3 | |
Ensembl transtripts involved in fusion gene | ENST00000260731, | ENST00000371483, ENST00000371481, ENST00000604414, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 2 X 1 X 1=2 |
# samples | 4 | 1 | |
** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/2*10)=2.32192809488736 | |
Context | PubMed: KIF11 [Title/Abstract] AND FFAR4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KIF11 | GO:0090307 | mitotic spindle assembly | 19001501 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-63-7021-01A | KIF11 | chr10 | 94399657 | + | FFAR4 | chr10 | 95346977 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000260731 | ENST00000371483 | KIF11 | chr10 | 94399657 | + | FFAR4 | chr10 | 95346977 | + |
Frame-shift | ENST00000260731 | ENST00000371481 | KIF11 | chr10 | 94399657 | + | FFAR4 | chr10 | 95346977 | + |
5CDS-intron | ENST00000260731 | ENST00000604414 | KIF11 | chr10 | 94399657 | + | FFAR4 | chr10 | 95346977 | + |
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FusionProtFeatures for KIF11_FFAR4 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
KIF11 | FFAR4 |
Motor protein required for establishing a bipolarspindle during mitosis (PubMed:19001501). Required in non-mitoticcells for transport of secretory proteins from the Golgi complexto the cell surface (PubMed:23857769).{ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. | Receptor for medium and long-chain free fatty acids(FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as areceptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells.The anti-inflammatory effects involve inhibition of TAK1 through abeta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent ofthe G(q)/G(11)-coupled pathway. Mediates potent insulinsensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids.Mediates FFA-induced inhibition of apoptosis in enteroendocrinecells. May play a role in the regulation of adipocyte developmentand differentiation. {ECO:0000269|PubMed:15619630}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KIF11_FFAR4 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KIF11_FFAR4 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KIF11 | NCOR1, DCTN1, KIF11, TNFAIP3, RPAP1, MEPCE, MYSM1, KAT2B, ELAVL1, TRAF4, PINK1, CDK1, KIF5A, SMURF1, PEX14, PAN2, NPM1, FBXO6, RAPGEF2, PPARG, MLF1, CASP1, DNM3, TFDP3, C9orf41, C17orf59, WHSC1, PI4K2A, SNRNP70, NTRK1, MED4, SRPK2, ADARB2, AP2A2, ANK3, ANXA1, ANXA7, CALD1, CETN2, DECR1, ACSL3, FASN, H3F3A, HDLBP, TACC3, LAMB1, LDHA, MAP4, KMT2A, MYO1C, ORC2, PDE3A, PFKM, PRKCA, RPL23A, RPL28, RPL32, RPL36AL, RPL37A, RPS3A, RPS6, RPS23, SNRPD3, SUV39H1, TLN1, ZKSCAN8, LUZP1, BRPF1, HIST1H3A, DUSP11, EIF3A, EIF3I, NOLC1, MED14, TRIP4, CEP350, ILVBL, ANKLE2, KIAA0922, GTPBP4, EDC4, HSPB8, AP3M1, PNMA3, IRAK4, MRPL27, NOL7, NT5DC3, METTL13, ACSL5, ARID4B, H2BFS, PLEKHA5, DGCR8, RBM28, ZGRF1, PCID2, ACTR10, MTUS1, MLST8, SPATS2, PRR3, DYNLRB1, FLYWCH1, SPIRE2, CEP295, FAM122A, RBM45, DHRS13, ANKS6, C2orf69, DDX51, H3F3C, GAN, SNW1, CDC5L, YWHAZ, DPPA4, RC3H1, ATOH1, CRBN, RNF20, RNF40, SPERT, LINC01587, CYLD, BRCA1 | FFAR4 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIF11_FFAR4 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIF11_FFAR4 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KIF11 | C0002938 | Aneuploidy | 1 | CTD_human |
Hgene | KIF11 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Hgene | KIF11 | C1257806 | Chromosomal Instability | 1 | CTD_human |
Hgene | KIF11 | C1835265 | Lymphedema, microcephaly and chorioretinopathy syndrome | 1 | ORPHANET;UNIPROT |