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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18783

FusionGeneSummary for KIF11_FFAR4

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF11_FFAR4
Fusion gene ID: 18783
HgeneTgene
Gene symbol

KIF11

FFAR4

Gene ID

3832

338557

Gene namekinesin family member 11free fatty acid receptor 4
SynonymsEG5|HKSP|KNSL1|MCLMR|TRIP5BMIQ10|GPR120|GPR129|GT01|O3FAR1|PGR4
Cytomap

10q23.33

10q23.33

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF11TR-interacting protein 5TRIP-5kinesin-like protein 1kinesin-like spindle protein HKSPkinesin-related motor protein Eg5thyroid receptor-interacting protein 5free fatty acid receptor 4G-protein coupled receptor 120G-protein coupled receptor 129G-protein coupled receptor GT01G-protein coupled receptor PGR4omega-3 fatty acid receptor 1
Modification date2018052720180523
UniProtAcc

P52732

Q5NUL3

Ensembl transtripts involved in fusion geneENST00000260731, ENST00000371483, 
ENST00000371481, ENST00000604414, 
Fusion gene scores* DoF score4 X 4 X 4=642 X 1 X 1=2
# samples 41
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/2*10)=2.32192809488736
Context

PubMed: KIF11 [Title/Abstract] AND FFAR4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIF11

GO:0090307

mitotic spindle assembly

19001501


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-63-7021-01AKIF11chr10

94399657

+FFAR4chr10

95346977

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000260731ENST00000371483KIF11chr10

94399657

+FFAR4chr10

95346977

+
Frame-shiftENST00000260731ENST00000371481KIF11chr10

94399657

+FFAR4chr10

95346977

+
5CDS-intronENST00000260731ENST00000604414KIF11chr10

94399657

+FFAR4chr10

95346977

+

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FusionProtFeatures for KIF11_FFAR4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF11

P52732

FFAR4

Q5NUL3

Motor protein required for establishing a bipolarspindle during mitosis (PubMed:19001501). Required in non-mitoticcells for transport of secretory proteins from the Golgi complexto the cell surface (PubMed:23857769).{ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. Receptor for medium and long-chain free fatty acids(FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as areceptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells.The anti-inflammatory effects involve inhibition of TAK1 through abeta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent ofthe G(q)/G(11)-coupled pathway. Mediates potent insulinsensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids.Mediates FFA-induced inhibition of apoptosis in enteroendocrinecells. May play a role in the regulation of adipocyte developmentand differentiation. {ECO:0000269|PubMed:15619630}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIF11_FFAR4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIF11_FFAR4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF11NCOR1, DCTN1, KIF11, TNFAIP3, RPAP1, MEPCE, MYSM1, KAT2B, ELAVL1, TRAF4, PINK1, CDK1, KIF5A, SMURF1, PEX14, PAN2, NPM1, FBXO6, RAPGEF2, PPARG, MLF1, CASP1, DNM3, TFDP3, C9orf41, C17orf59, WHSC1, PI4K2A, SNRNP70, NTRK1, MED4, SRPK2, ADARB2, AP2A2, ANK3, ANXA1, ANXA7, CALD1, CETN2, DECR1, ACSL3, FASN, H3F3A, HDLBP, TACC3, LAMB1, LDHA, MAP4, KMT2A, MYO1C, ORC2, PDE3A, PFKM, PRKCA, RPL23A, RPL28, RPL32, RPL36AL, RPL37A, RPS3A, RPS6, RPS23, SNRPD3, SUV39H1, TLN1, ZKSCAN8, LUZP1, BRPF1, HIST1H3A, DUSP11, EIF3A, EIF3I, NOLC1, MED14, TRIP4, CEP350, ILVBL, ANKLE2, KIAA0922, GTPBP4, EDC4, HSPB8, AP3M1, PNMA3, IRAK4, MRPL27, NOL7, NT5DC3, METTL13, ACSL5, ARID4B, H2BFS, PLEKHA5, DGCR8, RBM28, ZGRF1, PCID2, ACTR10, MTUS1, MLST8, SPATS2, PRR3, DYNLRB1, FLYWCH1, SPIRE2, CEP295, FAM122A, RBM45, DHRS13, ANKS6, C2orf69, DDX51, H3F3C, GAN, SNW1, CDC5L, YWHAZ, DPPA4, RC3H1, ATOH1, CRBN, RNF20, RNF40, SPERT, LINC01587, CYLD, BRCA1FFAR4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF11_FFAR4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF11_FFAR4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF11C0002938Aneuploidy1CTD_human
HgeneKIF11C0027659Neoplasms, Experimental1CTD_human
HgeneKIF11C1257806Chromosomal Instability1CTD_human
HgeneKIF11C1835265Lymphedema, microcephaly and chorioretinopathy syndrome1ORPHANET;UNIPROT