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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1878

FusionGeneSummary for ANKRD6_CASP8AP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD6_CASP8AP2
Fusion gene ID: 1878
HgeneTgene
Gene symbol

ANKRD6

CASP8AP2

Gene ID

22881

9994

Gene nameankyrin repeat domain 6caspase 8 associated protein 2
Synonyms-CED-4|FLASH|RIP25
Cytomap

6q15

6q15

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 6diego homologdiversinCASP8-associated protein 2FLASH homolog RIP25FLICE associated hugeFLICE-associated huge proteinhuman FLASH
Modification date2018052320180522
UniProtAcc

Q9Y2G4

Ensembl transtripts involved in fusion geneENST00000369408, ENST00000520886, 
ENST00000339746, ENST00000447838, 
ENST00000522441, ENST00000485637, 
ENST00000520793, 
ENST00000551025, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 2=8
# samples 32
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: ANKRD6 [Title/Abstract] AND CASP8AP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-85-8481-01AANKRD6chr6

90143094

+CASP8AP2chr6

90581008

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000369408ENST00000551025ANKRD6chr6

90143094

+CASP8AP2chr6

90581008

+
3UTR-3UTRENST00000520886ENST00000551025ANKRD6chr6

90143094

+CASP8AP2chr6

90581008

+
5UTR-3UTRENST00000339746ENST00000551025ANKRD6chr6

90143094

+CASP8AP2chr6

90581008

+
5UTR-3UTRENST00000447838ENST00000551025ANKRD6chr6

90143094

+CASP8AP2chr6

90581008

+
intron-3UTRENST00000522441ENST00000551025ANKRD6chr6

90143094

+CASP8AP2chr6

90581008

+
intron-3UTRENST00000485637ENST00000551025ANKRD6chr6

90143094

+CASP8AP2chr6

90581008

+
intron-3UTRENST00000520793ENST00000551025ANKRD6chr6

90143094

+CASP8AP2chr6

90581008

+

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FusionProtFeatures for ANKRD6_CASP8AP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD6

Q9Y2G4

CASP8AP2

Recruits CKI-epsilon to the beta-catenin degradationcomplex that consists of AXN1 or AXN2 and GSK3-beta and allowsefficient phosphorylation of beta-catenin, thereby inhibitingbeta-catenin/Tcf signals. {ECO:0000250}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKRD6_CASP8AP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKRD6_CASP8AP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANKRD6AXIN2, GSK3B, CSNK1ECASP8AP2TRAF2, CASP8AP2, FADD, FAS, CASP8, UBE2I, GLUL, SREBF2, CALM1, TRIM21, PIAS1, CASP10, SUMO2, SUMO1, CTBP2, CREM, PML, BCL2L1, MX1, HDAC1, SCOC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKRD6_CASP8AP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKRD6_CASP8AP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource