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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18763

FusionGeneSummary for KIAA1958_WDR34

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1958_WDR34
Fusion gene ID: 18763
HgeneTgene
Gene symbol

KIAA1958

WDR34

Gene ID

158405

89891

Gene nameKIAA1958WD repeat domain 34
Synonyms-DIC5|FAP133|SRTD11|bA216B9.3
Cytomap

9q32

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein KIAA1958WD repeat-containing protein 34
Modification date2018052220180523
UniProtAcc

Q8N8K9

Q96EX3

Ensembl transtripts involved in fusion geneENST00000337530, ENST00000374244, 
ENST00000536272, 
ENST00000372715, 
ENST00000483181, 
Fusion gene scores* DoF score4 X 2 X 4=323 X 1 X 3=9
# samples 53
** MAII scorelog2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIAA1958 [Title/Abstract] AND WDR34 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-91-6840-01AKIAA1958chr9

115249398

+WDR34chr9

131403218

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000337530ENST00000372715KIAA1958chr9

115249398

+WDR34chr9

131403218

-
5UTR-intronENST00000337530ENST00000483181KIAA1958chr9

115249398

+WDR34chr9

131403218

-
5UTR-3CDSENST00000374244ENST00000372715KIAA1958chr9

115249398

+WDR34chr9

131403218

-
5UTR-intronENST00000374244ENST00000483181KIAA1958chr9

115249398

+WDR34chr9

131403218

-
5UTR-3CDSENST00000536272ENST00000372715KIAA1958chr9

115249398

+WDR34chr9

131403218

-
5UTR-intronENST00000536272ENST00000483181KIAA1958chr9

115249398

+WDR34chr9

131403218

-

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FusionProtFeatures for KIAA1958_WDR34


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1958

Q8N8K9

WDR34

Q96EX3

Critical for ciliary functions, essential to normaldevelopment and survival, most probably as a previouslyunrecognized component of the mammalian dynein-motor-basedintraflagellar transport (IFT) machinery. Acts as a negativeregulator of the Toll-like and IL-1R receptor signaling pathways.Inhibits the MAP3K7-induced NF-kappa-B activation pathway.Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' uponIl-1 beta stimulation. {ECO:0000269|PubMed:19521662,ECO:0000269|PubMed:24183449}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA1958_WDR34


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA1958_WDR34


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA1958AQP1, STAC, TCEA2, LMO4, SOCS3, RWDD2B, MCRS1, GABARAPL2, FAM124B, COASY, CEP19, KIAA1958WDR34MAPK6, MAP3K7, TRAF6, TAB3, TAB2, COIL, TRIM54, FCGR3B, KLK11, SUSD4, SUMF2, DOK3, TMEM25, CCNJL, CDK13, DYNLT1, XPO1, DUSP4, TCTEX1D2, DYNC1I1, RBM14-RBM4, CCT6B, CCT2, CCT3, UBR4, TBC1D31, CCT6A, CCT4, TCP1, DYNLL1, WDR60, DYNLL2, DYNLRB1, H3F3A, DYNLRB2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA1958_WDR34


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA1958_WDR34


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWDR34C3810200SHORT-RIB THORACIC DYSPLASIA 11 WITH OR WITHOUT POLYDACTYLY2UNIPROT